Conserved Protein Domain Family
C1_ScPKC1-like_rpt2

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cd20823: C1_ScPKC1-like_rpt2 
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins
ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Statistics
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PSSM-Id: 410373
Aligned: 26 rows
Threshold Bit Score: 94.2959
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens PKC-gamma binds two Zn2+ ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #              #  #              #  #    #  #       #     
P24583     478 HRIPHRFLPTSNr--gTKWCCHCGYILPWGr-hKVRKCSECgIMCHAQCAHLVPDFCGMSME 536  Saccharomyces cerevisiae S288C
KFH68539   476 HRIPHRFETFTNl--sPTWCSHCGHMLTFGr--RHKKCSECpVMAHDGCSDLVPNHCGMPAE 533  Mortierella verticillata NRRL 6337
TPX32251   749 YHIPHRFEPSTVt--pPAWCHHCGQLLPLGr-nQARRCSECkLQYHRECESVVPNYCGMTVS 807  Synchytrium microbalum
ORY37602    56 HRIPHRWTDDTVg---VSWCAHCGQLLPVTk-rGCKKCGECgVSAHSNCSLLVPDACGMTAA 113  Rhizoclosmatium globosum
RKO87475   462 YKIPHRWEQSTNl--gAAWCSHCGHILPIGr--KIHRCTECnKAAHKECSHMVPYFCGLAPE 519  Blyttiomyces helicus
ORY35996   469 YRIPHRFQPKTIl--lSSWCAHCGSMMGPGa--RIEKCAECgKCAHTSCKPMVPNFCQLKPE 526  Rhizoclosmatium globosum
CDH60357   443 YNIPHRFETVMVi--gTNWCSHCGLILPLAv-kNIKKCTECgAMYHAKCCQFVPNYCGIDME 501  Lichtheimia corymbifera JMRC:FSU:9682
ORY96124   505 LCIPHRFEPVTVv--sSSWCCHCSFMLPFAstkTAVRCAECgQTCHTRCQEFVPNFCGTSMK 564  Syncephalastrum racemosum
TPX74681   790 YNKPHTFEPKKSmnllRSWCTHCGTKVLVGe--KLVQCSECgKCAHDRCSAMVPNFCKLSLA 849  Chytriomyces confervae
ORY29260   439 YNKPHAFEPRSMn--lRSWCTHCGLKIMPNe--RRVQCSQCvKSAHEKCQPLVPNFCGLSLA 496  Rhizoclosmatium globosum

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