2FNF


Conserved Protein Domain Family
C1_RASSF1-like

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cd20820: C1_RASSF1-like 
protein kinase C conserved region 1 (C1 domain) found in the Ras association domain-containing protein 1 (RASSF1)-like family
The RASSF1-like family includes RASSF1 and RASSF5. RASSF1 and RASSF5 are members of a family of RAS effectors, of which there are currently 8 members (RASSF1-8), all containing a Ras-association (RA) domain of the Ral-GDS/AF6 type. RASSF1 has eight transcripts (A-H) arising from alternative splicing and differential promoter usage. RASSF1A and 1C are the most extensively studied RASSF1; both are localized to microtubules and involved in the regulation of growth and migration. RASSF1 is a potential tumor suppressor that is required for death receptor-dependent apoptosis. RASSF5, also called new ras effector 1 (NORE1), or regulator for cell adhesion and polarization enriched in lymphoid tissues (RAPL), is expressed as three transcripts (A-C) via differential promoter usage and alternative splicing. RASSF5A is a pro-apoptotic Ras effector and functions as a Ras regulated tumor suppressor. RASSF5C is regulated by Ras related protein and modulates cellular adhesion. RASSF5 is a potential tumor suppressor that seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. RASSF1 and RASSF5 contain a C1 domain, which is descibed in this model. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Statistics
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PSSM-Id: 410370
Aligned: 6 rows
Threshold Bit Score: 61.6896
Created: 24-Oct-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:2FNF; Mus musculus RASSF5 binds two Zn2+ ions.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #             #  #                 #      #    #  #       # 
2FNF_X         23 GHRFVELALrggPGWCDlCGREVLr-------qALRCAn----CKFTCHsECRSLIqlDCR 72   house mouse
Q9NS23         51 GHRFQPAGPa-tHTWCDlCGDFIWgvv----rkGLQCArlsadCKFTCHyRCRALVclDCC 106  human
XP_009860994   18 GHNFEAYELkewVNWCDaCGSVILslf----rkCVSCSk----CKMVCHeKCATTVslTCE 70   vase tunicate
PAA47207      119 GHRFVLVSLe-qPTYCDfCGQALFg-------lVHRCEy----CCTTCHtICSERLclSCR 167  Macrostomum lignano
RJW64162      115 GHHFCPIPLd-sDTFCDvCSWPICnlgndwepiCLRCAd----CHMTCHpRCLSNVqvTCH 170  Clonorchis sinensis
OQV22321      100 KHQFLILELe-qPSFCDlCGLLIWgvy----rlSLRCRn----CNLTCHpQCKQFLrlVCP 151  Hypsibius dujardini

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