Conserved Protein Domain Family
C1_DEF8
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cd20819: C1_DEF8 
protein kinase C conserved region 1 (C1 domain) found in differentially expressed in FDCP 8 (DEF-8) and similar proteins
DEF-8 positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. It is involved in bone resorption. DEF-8 contains a protein kinase C conserved region 1 (C1) domain followed by a putative zinc-RING and/or ribbon. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410369
Aligned: 55 rows
Threshold Bit Score: 68.8447
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Rattus norvegicus ROCK2 binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                  #  #               #  #    #  #       #     
Q6ZN54        195 RVLLEHRFYKEKSks-----vKQTCDKCNTIIWGLIQt--WYTCTGCYYRCHsKCLNLISKpCVSSKV 255  human
XP_009861002  149 KIILGHKLKKKVNkt-----lKHYCDCCSKLIWGLFQm--WYECTMCGFKCHaKCTTTVRRsCAARAH 209  vase tunicate
XP_012556961  628 KKVLGHQLQKQPHls-----lKVECDVCASIIWLLLQt--AYICNDCGFHCHkTCLRNIDKpCISNLK 688  Hydra vulgaris
KXJ27285      564 RKILGHQFIKEQDtka---lsNVICDRCGKWVWTMWQs--LFTCQDCQFHSHrKCLDMIRRhCASRKV 626  Exaiptasia pallida
XP_028392705  693 RKILSHQFSKKEGkke---gtKYFCDQCGKNIWTIWQt--LYTCNDCGYYSHrKCLEHIQRpCPKRNL 755  Dendronephthya gigantea
XP_018901960  171 RVLRGHHFSLQKRsvat-akaMKFCERCCRAIWTVLVs--WYECLDCGYECHiKCIENTVRiCANVKR 235  Bemisia tabaci
OAF68343      239 QSINGHLMKIKCKn------rTIYCDSCVKHIWRMFDt--LYECTACGFSCHkNCLVNIFRsCPRIEI 298  Intoshia linei
VVC45034      108 QVVYGHHLSLIWKsdw---ltTNFCDVCAKSIWKNMHq--FYKCIDCGYYCHvFCMENIKRiCTAIRA 170  Cinara cedri
XP_017298875   44 IIRNGHHFVLTKTqlgtsksqLKRCDMCCGYVTVLGLvmpWYECSDCRYVVHvKCVSATRRtCVFVKA 111  Asian citrus psyllid
CRL07782       93 ISIAHHNFKILKQyp----skRIFCDFCTNIIWMFQQ---CYSCVQCYYFVHtKCLKYVTRtCAHVIV 153  Clunio marinus

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