Conserved Protein Domain Family
C1_Myosin-IX
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cd20818: C1_Myosin-IX 
protein kinase C conserved region 1 (C1 domain) found in the unconventional myosin-IX family
Myosins IX (Myo9) is a class of unique motor proteins with a common structure of an N-terminal extension preceding a myosin head homologous to the Ras-association (RA) domain, a head (motor) domain, a neck with IQ motifs that bind light chains, and a C-terminal tail containing cysteine-rich zinc binding (C1) and Rho-GTPase activating protein (RhoGAP) domains. There are two genes for myosins IX in humans, IXa and IXb, that are different in their expression and localization. IXa is expressed abundantly in brain and testis, and IXb is expressed abundantly in tissues of the immune system. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410368
Aligned: 31 rows
Threshold Bit Score: 96.9856
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Rattus norvegicus ROCK2 binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #            #  #             #  #    #  #       #    
B2RTY4       1997 HNGHIFKATQYsIPTYCEYCSSLIWi-mDRASVCKlCKYACHKKCCLKTTAkCSKKY 2052 human
RWS08451     1409 KCGHKFASVLAnIPTVCEVCSSLMWl-mDKMWVCSnCKLTCHKKCTAKVTVtCKDNS 1464 Dinothrombium tinctorium
KPM05639     1405 TFEHEFYFSTVnIYTVCEVCDSYMWl-mDKILICRhCKLTCHKKCFQKVTSkCGENS 1460 Sarcoptes scabiei
VDK42101     1637 HNGHKFKAEYVhVPTYCEICNQFMWh-aEKIFICTgCRISCHKKCHSKITHpCTRSA 1692 herring worm
NP_001248880 1472 HAGHRFRAEAVhVPTYCEVCNQLIWh-hEKLYTCVaCRISCHKKCQPKVTHpCQMTG 1527 Caenorhabditis elegans
ROT77863     1467 YGAHIFTHIMVnIPTQCEVCNSFLWl-sMKALTCQrCKVTCHQKCYKKADAkCSHEG 1522 Pacific white shrimp
XP_018012169 1756 HGSHKFTHLLInIATSCEVCNSFLWl-sAKGLTCSsCKLTCHEKCLPSVDVhCSPNA 1811 Hyalella azteca
VDN59835     1384 YKGHRFKLDLIhLPTCCEVCEGFMWn-tDKMYTCArCNATCHKKCHSKISKvCRTSP 1439 Guinea worm
OQR68416      271 HREHLFHTQLVhITTACEVCNHPIRlmlEKGLICSgCKLMCHKKCYSQITAsCRNMI 327  Tropilaelaps mercedesae
TKR95999     1516 YNNHKFKQDIVyVPTYCEVCNAFMGn-sEKIFICVnCKVSCHKKCHQKTHG-CKRTP 1570 Steinernema carpocapsae

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