2DB6


Conserved Protein Domain Family
C1_Stac
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cd20817: C1_Stac 
protein kinase C conserved region 1 (C1 domain) found in the SH3 and cysteine-rich domain-containing protein (Stac) family
Stac proteins are putative adaptor proteins that are important for neuronal function. There are three mammalian members (Stac1, Stac2 and Stac3) of this family. Stac1 and Stac3 contain two SH3 domains while Stac2 contains a single SH3 domain at the C-terminus. Stac1 and Stac2 have been found to be expressed differently in mature dorsal root ganglia (DRG) neurons. Stac1 is mainly expressed in peptidergic neurons while Stac2 is found in a subset of nonpeptidergic and all trkB+ neurons. Stac proteins contain a cysteine-rich C1 domain and one or two SH3 domains at the C-terminus. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410367
Aligned: 16 rows
Threshold Bit Score: 72.7457
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:2DB6; Homo sapiens Stac3 binds two Zn2+ ions.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #            #  #              #  #    #  #        #  
2DB6_A        18 HKFKDHFFkKPKFCDVCARMIVln-nKFGLRCKNCKTNIHEHCQSYVEmqrCSG 70  human
Q6ZMT1       111 HSFQEHVFkRASPCELCHQLIVgn-sKQGLRCKMCKVSVHLWCSEEIShqqCPG 163 human
XP_018671736  83 HVFSNHSFkKATFCDVCHRLLVgl-qRQGLRCKICKANLHSSCTNQIEe--CQG 133 vase tunicate
Q99469       108 HAFQEYIFkKPTFCDVCNHMIVgtnaKHGLRCKACKMSIHHKCTDGLApqrCMG 161 human
PIK37347     284 HVLQEYNFiKTTLCFRCKTPLKgl-mKQGVRCKICKVSVHHKCQENLPd--CSV 334 Japanese sea cucumber
XP_006817892 195 HSFQEHTFkKATSCAHCSEPLTgt-tKQGFKCVNCKIAVHHVCQSHVAp--CKK 245 Saccoglossus kowalevskii
GBM29223     346 HVFQEYTYkKITACDLCKEILRgh-sRQGVRCKLCKMNVHAECQEKVKv-aCQP 397 Araneus ventricosus
NP_001097327 107 HHLQEYTYkKITACDVCSQILRgh-tRQGLRCRICKLNAHGDCAPNLPr--CQP 157 fruit fly
EFX79902      48 HVFQENTYkKITPCDVCSQVLRgh-sRQGWKCRLCKINVHADCKSGVGr--CLP 98  common water flea
XP_004998879 830 HEFNTKTYvRETLCDVCNEVLAgv-aRQGLRCRACKMNVHQYCMESAPa-eCAG 881 Salpingoeca rosetta

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