Conserved Protein Domain Family

cd20810: C1_VAV 
protein kinase C conserved region 1 (C1 domain) found in VAV proteins
VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
PSSM-Id: 410360
Aligned: 44 rows
Threshold Bit Score: 67.2849
Created: 4-Oct-2019
Updated: 25-Oct-2021
Aligned Rows:
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:3BJI; Homo sapiens VAV1 binds two Zn2+ ions.
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1           #                  #  #             #  #    #  #      # 
PAV55837      576 SGHNLHYMSFsp----hePLHCHVCHKLFKGlffQGYECLnCHKLLHRQCLALEk-CN 628  Diploscapter pachys
PDM64976      626 TQHSVHFMTFkekageewPPCCAVCHNYLKGmffQGYKCErCQRVFHRECLSLEk-CE 682  Pristionchus pacificus
XP_022919864  522 KTHKFEMYTFd------kPTLCWVCAKYLKGllfQGYFCKeCGSAVHRDCIRTVgkCG 573  Onthophagus taurus
XP_024508428  586 NGHSVEYKTFk------dIIVCSFCDKFLKGlyyQGYKCEcCENIFHRECLMNNrkCP 637  Strongyloides ratti
RCN35247      356 TGHKIHYKSFkv----dvPYKCSVCDKFLKGlffQGYKCEnCGGLLHKTCISLRp-CA 408  dog hookworm
TRY72133      617 STHLPIMESFd------pPTSCSYCHKLLKGlffQGYRCKnCQKPMHKECITLLtkCG 668  Tigriopus californicus
OQR75215      553 TDHERLEMTTiq-----aPTYCSQCQKLMKGifyQGYSCVrCQKILHRDCIAQSrtCQ 605  Tropilaelaps mercedesae
Q45FX5        614 AFHSFRVDVKn-------PATCDVCDKLMKGlqyQGYKCEsCNMSMHKECLGLKk-CE 663  Caenorhabditis elegans
KHN70782      475 SGHSLRYYSYd------kATLCSHCQKLLAGlffQGYQCSvCKKNLHRACIAMNk-CN 525  dog roundworm

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