Conserved Protein Domain Family
C1_MRCK
?
cd20809: C1_MRCK 
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) family
MRCK is thought to be a coincidence detector of signaling by the small GTPase Cdc42 and phosphoinositides. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCK has been shown to promote cytoskeletal reorganization, which affects many biological processes. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
?
Statistics
?
PSSM-Id: 410359
Aligned: 35 rows
Threshold Bit Score: 87.3269
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding siteputative DAG/PE
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Caenorhabditis elegans Dkf-1 binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1         #            #  #             #  #    #  #        #   
Q9Y5S2       1026 HQFSIKSFSSPTQCSHCTSLMVGLiRQGYACEvCSFACHvsCKDGAPq-VCPIP 1078 human
O01583        958 HNFERMKIKTPTKCGHCTSILIGLdRQGLFCQsCQYACHvsCAERVSq-SCPVP 1010 Caenorhabditis elegans
GAV07996      990 HKFTVQTFSTPMKCTACSSLMVGLiRQGYFCSvCKIACHthCANQVPa-QCPPH 1042 Ramazzottius varieornatus
XP_024501822 1028 HRFVNVCFKMPTKCGYCTTILVGLeRQGIFCQdCQYSCHvsCAQKGLt-QCPVP 1080 Strongyloides ratti
XP_015791530  932 HSFIVRTFVAPLKCFHCTSLMIGLiRQGLICEtCGFVSHiaCASQGIq-LCPCD 984  two-spotted spider mite
XP_030539117  696 HMFVIRTFIMPLKCNLCTSLMTGLiRQGLVCEsCGLSCHvsCSKSIVnvPCPYD 749  Rhodamnia argentea
XP_017489742  968 HSFIIRTFITPLKCYICTSLMIGLvRQGYVCEvCGYACHvgCVDLGS--PCPFD 1019 snowberry fruit fly
XP_004348615 1196 HRIIPKSFLTPTKCDVCTSFLIGLvRQGLACAdCSYNFHyhCALEISp-VCPVK 1248 Capsaspora owczarzaki ATCC 30864
CBY09743      785 HLFMVRTFSEPTQCQICGTYMTGLwRQGVICSeCWLPCHisCAKDAPq-LCPGS 837  Oikopleura dioica
CAA73556      250 HRFKKYTFLGPTFCDMCGQLMHGIfRQQLKCDaCGTNCHtkCAQNMPp-LCGVN 302  Suberites domuncula

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap