1Y8F,5UE8


Conserved Protein Domain Family
C1_Munc13

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cd20807: C1_Munc13 
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family
The Munc13 gene family encodes a family of neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Statistics
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PSSM-Id: 410357
Aligned: 19 rows
Threshold Bit Score: 92.1568
Created: 4-Oct-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteputative DAG/PE
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:5UE8; Rattus norvegicus Munc13-1 C1 domain binds two Zn2+ ions.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #            #  #             #  #    #  #       #   
1Y8F_A         14 HNFEVWTATTPTYCYECEGLLWGIaRQGMRCTECGVKCHEKCQDLLnaDCKLN 66   Norway rat
5UE8_A         39 HNFEVWTATTPTYCYECEGLLWGIaRQGMRCTECGVKCHEKCQDLLnaDCLQR 91   Norway rat
P27715       1035 HNFATTTFQTPTFCYECEGLLWGLaRQGLRCTQCQVKVHDKCRELLsaDCLQR 1087 Caenorhabditis elegans
XP_023933590  481 HNFVVWSATSPTYCFECEGLLWGLaRQGVRCTECGVKCHEKCKDLLnaDCLQR 533  Lingula anatina
CBY09951      203 HNLVLWTAKHPTYCTNCEGLLWGItRQGLKCSDCGVKCHERCRDMVsiDCLQR 255  Oikopleura dioica
KPM05930      912 HNFQLWTATSPTYCYECEGLLWGIaRQGVRCTECGVKCHEKCKDLLnaDCLQR 964  Sarcoptes scabiei
OWF45986      606 HNFVVWTATSPTYCFECEGLLWGMvRQGVRCTECGVKCHEKCKDLLnaDCLQR 658  Yesso scallop
PFX34909      381 HRFEIWSTQVPAYCYECEGLLWGLaRQGLKCKECGVKCHERCKDLLnaDCLQR 433  Stylophora pistillata
EFX71298      149 HNFQPWTASSPTYCYECEGLLWGIaRQGVRCTECGVKCHEKCKDLLnaDCLQR 201  common water flea
ELT96420       68 HNFVVWSATSPTYCFECEGLLWGLaRQGVRCTECGVKTHEKCKDLLnaDCLQR 120  Capitella teleta

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