Conserved Protein Domain Family

cd20805: C1_DGK_rpt2 
second protein kinase C conserved region 1 (C1 domain) found in the diacylglycerol kinase family
The diacylglycerol kinase (DGK, EC family of enzymes plays critical roles in lipid signaling pathways by converting diacylglycerol to phosphatidic acid, thereby downregulating signaling by the former and upregulating signaling by the latter second messenger. Ten DGK family isozymes have been identified to date, which possess different interaction motifs imparting distinct temporal and spatial control of DGK activity to each isozyme. They have been classified into five types (I-V), according to domain architecture and some common features. All DGK isozymes, except for DGKtheta, contain two copies of the C1 domain. This model corresponds to the second one. DGKtheta harbors three C1 domains. Its third C1 domain is included here. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
PSSM-Id: 410355
Aligned: 43 rows
Threshold Bit Score: 31.2634
Created: 4-Oct-2019
Updated: 25-Oct-2021
Aligned Rows:
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Structure:1R79; Homo sapiens DGKdelta binds two Zn2+ ions.
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1         #                  #  #                   #  #    #    #            #   
1R79_A         28 HQWLEGNLpv------sAKCTVCDKTCGsvl-----rlqDWRCLWCKAMVHt--sCKESLLt-----kCSGP 81   human
Q13574        361 HHWVHRRRq-------dGKCRHCGKGFQqkftfhskeivAISCSWCKQAYHskvsCFMLQQie---epCSLG 422  human
XP_001750309  157 HHWISGVFdk------sKVCFRCTRPLGvkals--lqarAYRCSLCKRYIHl--dCLKNQFdvw--gtCDLG 216  Monosiga brevicollis MX1
OAF69317      195 HHWVKGHYk--------NKCDACGKRLKnq-------lkCHACSWCNRQIHi--dCTEMIHe-----tCDLG 244  Intoshia linei
XP_014152392  306 HFWVAGGYk-------eDRCISCLEKTKen-------tiSYKCSWCKSSLHd--vCKTNTDglssqdeCTLG 361  Sphaeroforma arctica ...
VDK72007       36 HHWIERRQk-------dLKCNACGKDAP-----------FLQCTWCKISYHskseCLQRSHyn---adCHLG 86   Dibothriocephalus latus
KOB74832      407 HHWVHRRSe-------kGKCKACGKKHGs----------RMKCSACKIVAHq--aCIDILMdrv-qfsCKPT 458  winter moth
Q39017        150 HQWAVRWTegadqtddsSFCSYCDESCSssfl---ggspIWCCLWCQRLVHv--dCHSNMSnet-gdiCDLG 215  thale cress
EFJ30273      158 HQWVERWMdvddipedrAYCMHCDEPCNasfl---ggsaIWRCMWCQRLVHv--dCHSVHSrns-selCDLG 223  Selaginella moellendo...
Q9FFN7        146 HHWSERWVnmddnadmtAFCFYCDEPCGipfi---easpMWHCLWCQRLIHv--kCHMIMSkes-gdaCDLG 211  thale cress

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