Conserved Protein Domain Family
C1_DGKtheta_typeV_rpt2
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cd20804: C1_DGKtheta_typeV_rpt2 
second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
Diacylglycerol (DAG) kinase (EC 2.7.1.107) is a lipid kinase that phosphorylates diacylglycerol to form phosphatidic acid. DAG kinase theta, also called diglyceride kinase theta (DGK-theta), is the only isoform classified as type V; it contains a pleckstrin homology (PH)-like domain and an additional C1 domain, compared to other DGKs. It may regulate the activity of protein kinase C by controlling the balance between the two signaling lipids, diacylglycerol and phosphatidic acid. DAG kinase theta contains three copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
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Statistics
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PSSM-Id: 410354
Aligned: 25 rows
Threshold Bit Score: 70.4084
Created: 22-Oct-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens DGKdelta binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #              #  #             #  #    #  #       #    
P52824        117 RVPVAHCFGPRGLh--KRKFCAVCRKVLEa---PALHCEVCELHLHPDCVPFACSDCRQCH 172  human
CCD75754      144 KSPVSHCWSDVGRf--KRKFCNVCRKRLEd--sLSVRCEVCEYYCHVDCQDYSINDCKQGA 200  Schistosoma mansoni
VVC30520       66 KNPVSHCWSEPARi-rNQRCCNVCRKRIDgr-tFSVTCEICHYYTHVDCIPSAVADCKETA 124  Cinara cedri
XP_028405836   84 KHPVAHSWCPLTSl--RRKFCNVCRKLLNd--sSDYSCEVCEYYVHKSCKDSAVNNCKRNA 140  Dendronephthya gigantea
OAF68875      127 KTNIPHFWSESVYc--KRKFCNYCRKRIDq---TGYFCIICNYHVHGNCRKTSGANCRYTY 182  Intoshia linei
XP_019850293  141 TNPIGHTWISPKSsanKRKWCNVCRKKITg---SAMYCKVCRRYAHKYCIGHELNNCKECS 198  Amphimedon queenslandica
NP_508190      79 KNPVAHTWSAPCLi--KRKYCCVCRKRTDd--aLSVECEVCEYYVHVDCSDLAVSDCKEAA 135  Caenorhabditis elegans
XP_030830206   86 KDPVPHTWSDPGHf--RKKFCNVCRRRLDd--aLSLHCEACEYYTHLGCLDFVVSNCIRFI 142  purple sea urchin
EFX64421       75 ETPVAHFWAESNHhsqKRRFCNVCRKRLDd--tYSFRCEVCDYHVHAECQDGALPNCRQAS 133  common water flea
XP_012750484   87 IRIAPHRFNLSSKg--LKKFCNYCRETTFtssdTCYTCIDCRYVAHDACRDKTPSNCRITY 145  Acytostelium subglobosum LB1

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