Conserved Protein Domain Family
C1_PKD_rpt2
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cd20796: C1_PKD_rpt2 
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD)
PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410346
Aligned: 27 rows
Threshold Bit Score: 106.603
Created: 7-Oct-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding siteputative DAG/PE
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Caenorhabditis elegans Dkf-1 binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #            #  #             #  #    #  #       #   
Q15139       270 PHTFVIHSYTRPTVCQYCKKLLKGLfRQGLQCKDCRFNCHKRCAPKVPnnCLGE 323 human
Q9BZL6       264 PHTFLIHSYTRPTVCQACKKLLKGLfRQGLQCKDCKFNCHKRCATRVPndCLGE 317 human
O94806       271 PHTFAVHSYTRPTICQYCKRLLKGLfRQGMQCKDCKFNCHKRCASKVPrdCLGE 324 human
NP_001170925  99 PHTFHIHTYTKPTVCQHCFRLLKGLfRQGLQCSDCKFNCHRRCQALVPpeCRGE 152 zebrafish
XP_006812382 218 PHTFAIHSYTKPTVCMSCKKLLRGLfRQGYQCKDCKFNCHKKCADKVPkdCLGE 271 Saccoglossus kowalevskii
PIK57544     190 PHTFMVHNYTTPTLCQFCKKLLYGIfRQGVQCKDCKFNCHKKCAPLVPrdCLGD 243 Japanese sea cucumber
PAA66413     155 PHTFDIHSYTKPTVCHFCRKLMYGLfRQGYQCKDCKYNCHKKCLPSVPksCEGV 208 Macrostomum lignano
XP_002131681 230 PHTFQVHTYTRPTVCMHCKKLLKGFfKQGLQCKDCKFNCHKRCKNEVPanCPEE 283 vase tunicate
TFK12170     221 PHTFQVHSYTRPTVCQHCKRLLKGLfRQGLQCKDCKFNCHKRCEQFVPdeCVGE 274 big-headed turtle
OCT84179     227 PHTFQVHSYTRPTICQHCRRLLKGLfRQGMQCKDCRFNCHRRCVEYVPdeCLGE 280 African clawed frog

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