Conserved Protein Domain Family
C1_PKD_rpt1
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cd20795: C1_PKD_rpt1 
first protein kinase C conserved region 1 (C1 domain) found in the protein kinase D (PKD) family
PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the first C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410345
Aligned: 24 rows
Threshold Bit Score: 107.387
Created: 4-Oct-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding siteputative DAG/PE
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Caenorhabditis elegans Dkf-1 binds two Zn2+ ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #            #  #             #  #    #  #       #   
Q9BZL6     136 IRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGA 191  human
O94806     152 IRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGV 207  human
CBY40406   132 ISKHNLVVHSYKGPTFCDYCDEFLWGLVKQGLKCTACGKNYHKRCVYHIPNDCEGY 187  Oikopleura dioica
KJE91895   186 GHPHHLTVKSYMKPTFCDYCNELLWGLVRQGLRCEDCMRNFHKRCAYKELNSCEAA 241  Capsaspora owczarzaki ATCC 30864
RXN19034   729 YRPHSLVVHSYRTPTFCHYCGEMLWGLVRQGLKCDGCGLDFHKRCAFKLPNDCSRV 784  rohu
RMC12599   167 IRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKCEDCRFNCHKRCAPKVPRDCLGE 222  Hirundo rustica rustica
Q15139     144 IRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGV 199  human
EDV21634     8 VRPHSLRVHSYRSPTFCDFCGQLLFGIIRQGLKCEGCNCNFHKRCAFKIPNNCTPP 63   Trichoplax adhaerens
CCD82848    29 VVGHNFQVHSYRSPHFCDYCGEVLFGLVRQGLRCSGCCQNFHKKCAYKIPNTCTGI 84   Schistosoma mansoni
OCT84179   102 IRPHILLVHSYKSPAFCDYCGEMLWGLVRQGLKCQGCGLNYHKRCAFKIPNNCRGV 157  African clawed frog

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