Conserved Protein Domain Family
FIX_AHH_RhsA-like

?
cd20744: FIX_AHH_RhsA-like 
Found in type sIX effector (FIX) domain of unknown function co-occurring with C-terminal AHH domain and some RhsA domains with RHS repeats
The Found in type sIX effector (FIX) domain is found N-terminal to known toxin domains and is genetically and functionally linked to type VI secretion system (T6SS), a widespread mechanism used by Gram-negative bacteria to antagonize neighboring cells. In Vibrio parahaemolyticus, it also co-occurs with C-terminal nuclease toxin PoNe (Polymorphic Nuclease effector) which is associated with several toxin delivery systems including type V, type VI, and type VII. In this subfamily, members contain a FIX domain that co-occurs with C-terminal domains such as AAH, a predicted nuclease domain with conserved AHH motif that is found in bacterial polymorphic toxin systems and functions as a toxin module. Some in this family have additional C-terminal domains such as RhsA protein which contains extended repeat regions and RHS repeats.
Statistics
?
PSSM-Id: 410942
Aligned: 28 rows
Threshold Bit Score: 99.2834
Created: 1-Oct-2019
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
TAK79305     2666 FNQLLLGNYTEDVTLLGta-------mQIGTGIVGVDLPaDIRDLTHDVTHwewtwGHAGQTALDAIGLVPgIGVVKNVD 2738 Aquabacterium...
WP_115482195  320 FEQAMAGKLSEKVTPLGtf-------lEVLIGFSGVDIFaDLRDLSADVIKfdpndPDIPGILLDSVGLIPiFGVAKNLD 392  Robinsoniella...
WP_028973396  190 IEYLIKGEYSDDPTGLAia-------iQLVLGFTGLDAPmDARDLTANLQK-----GEYGQALLSGIGLLPiVGNLKNLK 257  Spirochaeta c...
SFR92503       46 LEQIILGKFTEKGTVIGtv-------gEVGLAFTGVDVYqDLRDLTHDIITwettwEHFGETALDGIGLIPlVGALGKSD 118  [Clostridium]...
WP_081418909  499 GDFILKGNYADEVNAGGvg-------gSILLGLTGADLPmDVRDLFHNLTNwewnwGHAGETGLNTLSFFPvVGVLKNLR 571  Paenibacillus...
WP_135152155 2715 FQQLLIGKASSKVTVAGts-------iQVGLGLIGLDAPwDIQSIAYDLENwewslDHAGETLIDTASLVPiIGALKYGD 2787 Cohnella luoj...
WP_133379600  625 SGKYVLDSKNAEPNAGGvt-------gSILLGFTGADLPlDLRDIALDFWNwkwswSHAGETLLDLAAIVPvVGVLKNGK 697  Paenibacillus...
WP_128629811  632 LKFVIEGNYSDEGPTGLgi------gaNVLLGIFGLDVLaDGRDLFHNFTHwewswGHTGETLLNSIALVPfVGVVKNLK 705  Paenibacillus...
WP_010243614 4587 GMQVLKGSNYTKDEDITelgtysetlvGLGGSLIGADTPlDVRDFSGDIKNwkwtpGHVGGTVLDGIAVVPlIGAAKPLA 4666 Hungateiclost...
WP_076324566   55 VDFVIKGNYAEEATGLGig-------aNVLLELSGLDLPgDLRDLFHNFTHwkwswGHTGETLLNSVSLFTlVGALKNLK 127  Paenibacillus...
TAK79305     2739 EAA 2741 Aquabacterium sp.
WP_115482195  393 GVG 395  Robinsoniella sp. MCWD5
WP_028973396  258 FLD 260  Spirochaeta cellobiosiphila
SFR92503      119 EIL 121  [Clostridium] populeti
WP_081418909  572 FVD 574  Paenibacillus sp. Leaf72
WP_135152155 2788 EVK 2790 Cohnella luojiensis
WP_133379600  698 KLN 700  Paenibacillus dendritiformis
WP_128629811  706 YSD 708  Paenibacillus sp. KCOM 3021
WP_010243614 4667 NMG 4669 Hungateiclostridium cellulolyticum
WP_076324566  128 YSD 130  Paenibacillus lautus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap