Conserved Protein Domain Family
FIX_RhsA-like

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cd20743: FIX_RhsA-like 
Found in type sIX effector (FIX) domain of unknown function co-occurring with RhsA domains with RHS repeats
The Found in type sIX effector (FIX) domain is found N-terminal to known toxin domains and is genetically and functionally linked to type VI secretion system (T6SS), a widespread mechanism used by Gram-negative bacteria to antagonize neighboring cells. In Vibrio parahaemolyticus, it also co-occurs with C-terminal nuclease toxin PoNe (Polymorphic Nuclease effector) which is associated with several toxin delivery systems including type V, type VI, and type VII. In this subfamily, members contain a FIX domain that co-occurs with C-terminal RhsA-like domain, which contains extended repeat regions and RHS repeats. Some in this family have additional C-terminal domains such as AAH, a predicted nuclease domain with conserved AHH motif that is found in bacterial polymorphic toxin systems and functions as a toxin module.
Statistics
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PSSM-Id: 410941
Aligned: 59 rows
Threshold Bit Score: 46.8557
Created: 10-Sep-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_069016016   26 VGRGAAVFDAWLRDVSDGYVTLErikNVAGALPVVGN----IIALVDALGDIVTLaesk---------kpdpWDWVSLGI 92   Pseudomonas m...
POR06595       29 PSAEPVSPAVDIQTEPEDSTMLDiviQAAYMVPVLGN----VMAVGDVARDIVELcddsseg---epnhvnpWLWAILVI 101  Cobetia sp. M...
WP_124804586   60 GETPEAVIMMDVEEGSVTVLNVVv--QAAYMLPVVGN----VMAIGDVARDVVDLdgndadg---tpnyqnvWLWAVLVI 130  Halomonas sp....
WP_120185376   57 QPEVTMEEPKPNENGSNMVHYIM---EGAACIPIVGN----VIALKDVAFDTYEIcktdehnq--hsnlkniWLWVTLGV 127  Zymobacter pa...
AYZ66550       35 PATSPKVAAARAESVKHHSLEIFi--QCLYMLPVVGN----AMSLYDVGVDIYRIcsepg-------gakkvLSWSILAI 101  Burkholderia ...
WP_082079617   35 PATTPKLVHAPVESVTNHSQEIFi--QCLYMVPVVGN----AMSLWDVGADIYRIcsqpg-------aakdpFQWGILVI 101  Cupriavidus b...
AMV45657        6 VAAQPELKRVAVESVKDHAQQIFi--QCLYMVPLVGN----AMSLADVGTDLYRLfrnepdpasgkkyaenvLHWGVLAI 79   Paraburkholde...
TDR27756       22 VVTQIKKIEAWLLSVNPNAQLKN---LKGKPTPVVSN----IFAATGALIDIIAIadgtlpvi-kgsinpktAQYAYLTM 93   Hydromonas du...
WP_149285780   28 IDAPPQTPNVDVDLEPENSTALRivrEAAYMLPVVGN----VMSLADVAQDVMVLceddekg---lpntqntWLWVILVI 100  Halomonas sp....
WP_049044534   19 LAESQQTADIWIKAATHGVVTLNdvqSVLLNTPPFSLasdiMFSAYDIIEDTKALindh----------tkvENWIYLVI 88   Acinetobacter...
WP_069016016   93 NLIGVIPvp-pNMAAARMSLRPML 115  Pseudomonas mosselii
POR06595      102 DAIGIIPaagnASRPVRVASREAI 125  Cobetia sp. MM1IDA2H-1
WP_124804586  131 DAIGLVPafgnASRPIRVGTREGI 154  Halomonas sp. YLB-10
WP_120185376  128 DGIGIIPaagnASAPIRAVVRHGL 151  Zymobacter palmae
AYZ66550      102 DVIGVVPaagnATRPARAVVKEVL 125  Burkholderia multivorans
WP_082079617  102 DAVGVVPaagnASRPARAVAKEVL 125  Cupriavidus basilensis
AMV45657       80 DAIGVIPgagnASRPARAVVKDVL 103  Paraburkholderia caribensis
TDR27756       94 NLIGLTViq-pDEAHARMALRPIL 116  Hydromonas duriensis
WP_149285780  101 DAVGVIPaagnASRSIRAGAREAI 124  Halomonas sp. Y2R2
WP_049044534   89 DIIPLIPf--pATKVVGPPMKYGM 110  Acinetobacter bereziniae
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