Conserved Protein Domain Family
FIX_vWA-like

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cd20742: FIX_vWA-like 
Found in type sIX effector (FIX) domain of unknown function co-occurring with von Willebrand factor type A (vWA) domain or MSCRAMM family adhesin SdrC domain
The Found in type sIX effector (FIX) domain is found N-terminal to known toxin domains and is genetically and functionally linked to type VI secretion system (T6SS), a widespread mechanism used by Gram-negative bacteria to antagonize neighboring cells. In Vibrio parahaemolyticus, it also co-occurs with C-terminal nuclease toxin PoNe (Polymorphic Nuclease effector) which is associated with several toxin delivery systems including type V, type VI, and type VII. In this subfamily, members contain a FIX domain that co-occurs with domains such as the von Willebrand factor type A (vWA) domain, which has a wide variety of important cellular functions, and the MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules) family adhesin SdrC domain, that contains a variable-length C-terminal region of Ser-Asp (SD) repeats.
Statistics
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PSSM-Id: 410940
Aligned: 67 rows
Threshold Bit Score: 58.7661
Created: 10-Sep-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
SCL59977      441 DFLLGMFAGDFAPKDSMA------WLAGNLCSGGLSFIpvvgwvlgglaDIRDTVAALIH-------GDWVGAGLSILGL 507  Micromonospor...
WP_130981572 1263 DFAVGFTCGEMEFCNRGTm----aWLGGNIASGLLVFG-----------DVRDMVALASR-------GDWVGAGLCAVGL 1320 Glaciihabitan...
WP_011844825  203 ELVLGFTLGAYAEENHDNv----yYLIGSSLSGIVFVG-----------DIRDAGVYISQ-------GDKQMALVCLVGL 260  Methanoculleu...
PKL61355       95 EFVLGFTLGSYGAENHDNp----yYELGSLLSGIAVFG-----------DIRDAGIAISQ-------GDKQMALVCIVGI 152  Methanomicrob...
ODU63142     1520 ELYVGFYLGEIMYIPDSIp-----WLIGNIASGFIPVAgv-------iaDLRDAVGQLAR-------VEVLGAILSLIGA 1580 Leifsonia sp....
WP_127014975 1438 EAETGFFSGRIAFEDNPRkhsnpgFLLGWIASGIAVFG-----------DVRDAGDAVND-------RDWSDAGITLLGL 1499 Haloarcula sa...
WP_134668503  910 EFGMGFVCGEYCFAEDSHnn--vdYLTGWIISGIAIFG-----------DVRDISNYLIE-------QKGVELGVTVVGL 969  Halorussus sp...
PLS76524      277 EFLAGLFFGDFAREDGAGsag-isRTLGHLASGLFAVG-----------DVRDTLANVSA-------GHWRDAALSALGA 337  Actinobacteri...
WP_052666490  253 AFADGFVAGDLSERTYDSgalatlQGIGHIASGILLFG-----------DVRDTGAAAVAivrsggrEGWTDLGLSAAGF 321  Nitriliruptor...
WP_116715980  177 AFINGLVLGDYGGGEDSIile-giRITGQTVSSIIVVG-----------DIRDGVRAVQT-------GDEVSLGLILVGL 237  Euzebya tange...
SCL59977      508 VPyaGDAVAIPGKAAKFALK 527  Micromonospora chersina
WP_130981572 1321 IPgfGDAIGTSAKIVKFLKR 1340 Glaciihabitans sp. RP-3-7
WP_011844825  261 VPtgGDGARYISKIGKEMAE 280  Methanoculleus horonobensis
PKL61355      153 CPvgGDAGKVIGRITHIALH 172  Methanomicrobiales archaeon HGW-Methanomicrobiales-2
ODU63142     1581 IPilGDGIRAVAVLAKAAVR 1600 Leifsonia sp. SCN 70-46
WP_127014975 1500 APeiGDAAKTSKIISRVSRY 1519 Haloarcula salaria
WP_134668503  970 VPavGDTPRITQIFGKAAKY 989  Halorussus sp. DLLS-82
PLS76524      338 IPivGDLAKAEDAVDASRVA 357  Actinobacteria bacterium
WP_052666490  322 VPivGDGIKGARRAARVVDD 341  Nitriliruptor alkaliphilus
WP_116715980  238 IPvyGDGARAAGLIGESAVD 257  Euzebya tangerina
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