Conserved Protein Domain Family
PoNe_DUF4280
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cd20738: PoNe_DUF4280 
Polymorphic Nuclease effector (PoNe) co-occurring with an N-terminal DUF4280 domain
The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains proteins with PoNe domains that typically co-occur with an N-terminal domain of unknown function (DUF4280), which has a single completely conserved residue C that may be functionally important.
Links
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Statistics
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PSSM-Id: 410647
Aligned: 14 rows
Threshold Bit Score: 158.68
Created: 5-Sep-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PoNe conserved
Feature 1: PoNe conserved motif, 10 residue positions
Conserved feature residue pattern:K G [DE] G I D [FY] [FY] [DE] KClick to see conserved feature residue pattern help
Evidence:
  • Comment:conserved motif: Kx3GExnGIDx2YxnYx3ExK discovered in PoNe family members
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #   ##                                ###  #          #   # #               
WP_089080743 159 DYRRHGNYGEMKSNQYYDdnAFRDIRKEHPv--mDIDKPTASGIDGAYEKGGT-----YRVDDAKYNTASLQnt----tn 227 Flavobacterium ...
EFC67648      14 TNIRKGNYGEMAANRLYAarGMQNIRSKHPl--mYIDKPTGKGFDGAYTKNGE-----YIVDDAKPWKKGPEkt----kd 82  Prevotella sp. ...
WP_115956468 156 SQHRKGNYGEMKDQVYYReqGWRDIRKESPn--mDIDKPTASGIDGAYEKGGV-----YRETDAKYDQAKLKtnk---gs 225 Chryseobacteriu...
WP_083549416 161 DFRRGGNYGEMKDQVFHRqeGWRDVRSEHPn--mDIDKPTSPGIDGAYEKNGT-----YKLTDAKYNGAKLEnt----at 229 Chitinophaga ji...
WP_146311553 150 YNTRTGNYGEMKDQVYHRenGWRDIKAEHPn--mNIDKPTASGIDGAYEKGGF-----FKETDAKYNTATLRtnp---gs 219 Apibacter sp. CB23
WP_004383476 149 NDAMKANYGEILDNRLYSsqGWSYIRKSHPiidiQSTNSLKSGIDGVYTKNGE-----YLVTDAKAYNTMRSpsldtgas 223 Prevotella vero...
WP_125119187 138 TDAEKGNLGEMLMDQYYIarGYRPIHKDRVv---DLEHKSGQGIDGAYEKEDAngkkvYVIVDAKVNSSRLNkgl---ad 211 Erysipelotricha...
SCJ69298      60 TDAEKGNLGEMLMDQYYIsqGYVPIHSPRVt---DLKHKSGQGIDGVYEKTDFdgskeYVIADAKVNFSKLNkgl---ad 133 uncultured Euba...
WP_051604925 408 KNIQKGNYGEMKMDVYFAkrGYKRISLDRVt---SIDAPTHHGIDGVYYNPEGkp--pYVIAEAKFSSTGIPrlsk-lrd 481 Lachnobacterium...
RSK17103     402 SNMRKGNYGEMTTDEIYRqlGYERISLDMTt---EIDGATHHGIDGVYYNPNGhp--pYIIAEAKYGGSRLSyl----kg 472 Streptococcus o...

Feature 1                                                                    
WP_089080743 228 SGRELSKNWVqDHIDKGAISNEADKlai--erANNNGTLERGVSRTNTD-GSMRYEPSND 284 Flavobacterium branchiophilum
EFC67648      83 SGKQLSQKWVgRHLEQGAVPENHAEam---kaANDKNSLRRTVTHVDGD-GNMRIINYAT 138 Prevotella sp. oral taxon 317 str. ...
WP_115956468 226 GNRELDVKWTnDHIDNGAITSAEDArrm--rrANNNGSLERAVTHIDTE-GNMRNIPVND 282 Chryseobacterium flavum
WP_083549416 230 YGRETSRRWTkFHTDNGGINPADREaf---srANDTGTLQREMVKTMPN-GDMHSETQND 285 Chitinophaga jiangningensis
WP_146311553 220 GNRELDINWTnDHIDRGAIANQEDAram--krANNNGTLQREVTHIDTN-GTMKSKPMND 276 Apibacter sp. CB23
WP_004383476 224 SGRELSQGWVeNHIRNGTVKDSHTAai---ttANNEGKLQRSVTQVNHTnRDMRSIPVDD 280 Prevotella veroralis
WP_125119187 212 GTDQMSDEWVvKRLEKAVGKKKADEild--ayEDDPQSIRKELYHFSYG-NSPDGMSKAD 268 Erysipelotrichaceae bacterium SG0102
SCJ69298     134 GTNQMSDVWVeKRLDNAVGKEKADEird--ayEDDSNSVSKVVYHFSYA-DSVNGKSKSD 190 uncultured Eubacterium sp.
WP_051604925 482 GTRQMSEKWI-TKPSKRGLSRLDQAvgkekalDILTKDYKSVLVTIDKT-GDVKTCILDA 539 Lachnobacterium bovis
RSK17103     473 GTKQMDSNWIgSRLEKAVGEEHYDLik----kAYKTGDVQAQLVKIQKN-GNIMINNLDA 527 Streptococcus oralis

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