Conserved Protein Domain Family
PoNe_HINT
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cd20737: PoNe_HINT 
Polymorphic Nuclease effector (PoNe) domain co-occurring with N-terminal domains such as the HINT domain
The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains proteins with PoNe domains that typically co-occur with a pre-toxin HINT domain, a member of the HINT superfamily of proteases usually found N-terminal to the toxin module in polymorphic toxin systems; the HINT domain is predicted to function in releasing the toxin domain by autoproteolysis.
Links
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Statistics
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PSSM-Id: 410646
Aligned: 19 rows
Threshold Bit Score: 70.1568
Created: 27-Sep-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PoNe conserved
Feature 1: PoNe conserved motif, 10 residue positions
Conserved feature residue pattern:K G [DE] G I D [FY] [FY] [DE] KClick to see conserved feature residue pattern help
Evidence:
  • Comment:conserved motif: Kx3GExnGIDx2YxnYx3ExK discovered in PoNe family members
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   ##                                            ###  #                        
WP_114970023  406 KGFKGEIVVREKLEAAgytmvrgvdn-----------kaddalakwnGQKGIDGIYIDGk-------------------- 454  Rhodoferax sp...
WP_147935015  389 KGYRGEREVFIDLLAKgyepvgksfdpr-------gmspddafkawdGQTGIDGIYKDKn-------------------- 441  Massilia sp. ...
KKT40261       33 QGDLGEQMATEHAVKElnlgt---------------------erfdkKIHGYDNVFRDGa-------------------- 71   Candidatus Co...
WP_056143024  374 RGFYAEHQIFEELLERgmqpvgksfdpr-------gknpqelfakwyGSKGIDGIYKDAd-------------------- 426  Duganella sp....
WP_010105202  376 KGFKWEVEVFEHMTTAgyepmkgslnpv-------gktpqeafsewsGKQDIDGRYRRStgikdk----------dgdyi 438  Verminephroba...
WP_056142200 1475 RGFVGELDAWSFLISGkkklqimgnktldpaairnqadydaqlagykGAKGMDGAFEERpgffka----------iiggk 1544 Duganella sp....
RXZ77766      393 KGFRGEVITFMDMIKAgaeplgrtlglnp-----kgrspvqafkawhGRTGIDGIYKVRskvrdkhgnvvkdkdgkdvee 467  Verminephroba...
QDV45478     3954 GGELGTVKTAQKLGLEpldd------------------------fivRYRGIDGLYKNG--------------------- 3988 Planctomycete...
WP_131905123 1480 TGLVGEKRTTQAMEDAgwtplgntqkss--------gtvdddlpgyqGQNGIDGIFKRQksd----------------gt 1535 Cocleimonas f...
WP_036436686 2104 IGLFGELDSVANLLDGgfetlgrtldprqv---tsldaferallsrrGQQDIDFIVSRErp-----------------gv 2163 Mycolicibacte...

Feature 1           #   # #                                    
WP_114970023  455 GNYVIVESKATGGvnpsdpag--cvaglcnTKSGRQMSEDWIIER 497  Rhodoferax sp. OTU1
WP_147935015  442 GNYVIIESKATGGtkkadpeg-cvdrlctvKSGARQMSNEWLQDR 485  Massilia sp. GEM5
KKT40261       72 GKLVIVEAKATKSsgva---------slkdTVHGREGSVEWVEYK 107  Candidatus Collierbacteria bacterium GW2011_GWC2...
WP_056143024  427 GNYIIIESKATGGakpddpag-ckgklcmtKNSGRQLSKKWTEER 470  Duganella sp. Leaf61
WP_010105202  439 YEYVLVESKATGGakngipdd-tvakltmtKNTGRQMSTKWVSNH 482  Verminephrobacter aporrectodeae
WP_056142200 1545 PMYYLVESKATAGvfpanptk--sildttrNGGGRQMSETWLNSN 1587 Duganella sp. Leaf61
RXZ77766      468 VTYVIIESKATGGmkngildd-ivakltknKNDERQMSEAWIERN 511  Verminephrobacter sp. Larva24
QDV45478     3989 DKFVIAEAKGFSKgssp---------tlgiTKHGEQLSQQWIQRQ 4024 Planctomycetes bacterium Enr13
WP_131905123 1536 YEYVIVETKASTGgstgs--------lnqtVDGDTQLSSKWIDDR 1572 Cocleimonas flava
WP_036436686 2164 TEYLLGDAKATADisprapegagrlktmssDPDIQQLGSDWLRGH 2208 Mycolicibacterium mageritense

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