Conserved Protein Domain Family
PoNe_PAAR-like
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cd20733: PoNe_PAAR-like 
Polymorphic Nuclease effector (PoNe) co-occurring with an N-terminal PAAR domain
The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contain members with PoNe domains that typically co-occur with N-terminal domains such as proline-alanine-alanine-arginine (PAAR) repeat domains that form a sharp conical extension on VgrG spikes, which is a trimeric protein complex of the bacterial type VI secretion system (T6SS).
Links
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Statistics
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PSSM-Id: 410642
Aligned: 28 rows
Threshold Bit Score: 159.024
Created: 5-Sep-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PoNe conserved
Feature 1: PoNe conserved motif, 10 residue positions
Conserved feature residue pattern:K G [DE] G I D [FY] [FY] [DE] KClick to see conserved feature residue pattern help
Evidence:
  • Comment:conserved motif: Kx3GExnGIDx2YxnYx3ExK discovered in PoNe family members
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #   ##                                 ###  #          #   # #                 
WP_043159085    291 KKGIYGEIISDNWManHKFENLLPEHrrvrsl-ndkprGRGIDGIYKNTn--pPPPYVVTETKFRTAggeyidgdgtk-- 365  Aeromonas h...
WP_022825205    187 EKGVYGEHISDTYMraQGHTKLNDGGlvtppppggtarGNGIDGVWKHGn--pPPDYIITEAKYGKSrlg---------- 254  Hymenobacte...
WP_052732858    214 VDGCLGEYQADKLFaaQGHQKLNHGGqlvgl--ldpprGTGIDGVWRNAt--pPPEYIITETKYGKPpkl---------- 279  Hymenobacte...
WP_061118291    327 KKGIYGEIVSDQYMggKGYENVMLKDrqpprsledvpiGRGIDGVYKKPpgelPPPYVVTETKYRTGgkftdkdlk---- 402  Caballeroni...
WP_039087975    293 RKGIYGEQVSDEFMeeRNFRSMLSPErqkrllegetatGRGIDGVYANPk--pPPPYIITETKFRTKageyidsdgrlsk 370  Gallibacter...
WP_107707057    323 RKGIFGEQVSDDWMkaRKFTSELSADrqmrll-eekptGRGIDGVYRNNe--pPPPYVITETKFRTGgnfspsq------ 393  unclassifie...
WP_051122585    324 QKGIYGEVVSDQYMlgKGHENLLSAArgprsl-emkptGRGLDGVYRNAh--pPPPFIITETKYRTGgtfspgslp---- 396  Pseudomonas
WP_135433161    467 ANGRLGEYQADIAFanEGHIKLDSPHtald----apagRQGLDGVWRNAt--pPPEYIVTETKFDTAk------------ 528  Hymenobacte...
WP_086688278   1582 QKGKFGEQKADAFMeeNGFVKRGSHDapgsg--ggkpkPQGIDGVYENTn--pPPKWVVGEAKYDTAgyg---------- 1647 Nostoc sp. T09
WP_051122585.1  324 QKGIYGEVVSDQYMlgKGHENLLSAArgprsl-emkptGRGLDGVYRNAh--pPPPFIITETKYRTGgtfspgslp---- 396 

Feature 1                                                                                 
WP_043159085    366 --stqllsmtkgSGKQMSGQWId--kRLPDEITDKKILkdlk----negYEAWLMIVDESGkVIQITKLD 427  Aeromonas hydrophila
WP_022825205    255 ---------mtlDGRQMSDTWIlgsgRLGKATNKREAAairra-ffsgrVEKRLHKVDSTG-RLEETILL 313  Hymenobacter norwiche...
WP_052732858    280 ----------tkATKQMTNEWIfgsdRLTRAVDDEEEAdrittaqatgqVEKRVLHIDFDG-KLTEYKIE 338  Hymenobacter terrenus
WP_061118291    403 ---ptkgsknypSAKQMSDKWVe--yRLPDAVGDERAVdil-----derFEKWLMVVDESGeVISITKLD 462  Caballeronia turbans
WP_039087975    371 akkvedllgstkEGKQMSDDWIk--nRLLSAVGDPFIAkdin----tkgYDKWLMIVDDNGkVVEIYKIG 434  Gallibacterium anatis
WP_107707057    394 ------lpmtkgSGKQMSGPWId--sRLADAVSGQTKArtil----kadYESWLIVVDENGrVVDITKLD 451  unclassified Paraburk...
WP_051122585    397 ---vtkgskgfpSARQMSDAWIe--pRLDLDLGKKQAEeia-----fsgYERWLMIVDESGvVTKIVKLD 456  Pseudomonas
WP_135433161    529 -----------lSKGQMSDNWIr--kNLNKLSDQKLADkirda-mdtgqVEKRLLQVSKETgEVIQTVLK 584  Hymenobacter sp. 92R-1
WP_086688278   1648 ---------qtqSGKQMSEPWAd--aRLDHAVGKKLADqir-----ldgYERWELRVDPSG-KVIKTKIT 1700 Nostoc sp. T09
WP_051122585.1  397 ---vtkgskgfpSARQMSDAWIe--pRLDLDLGKKQAEeia-----fsgYERWLMIVDESGvVTKIVKLD 456

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