Conserved Protein Domain Family
PoNe_FilH-like
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cd20730: PoNe_FilH-like 
Polymorphic Nuclease effector (PoNe) co-occurring with filamentous hemagglutinin N-terminal domain repeats
The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains proteins with PoNe domains that typically co-occur with N-terminal hemagglutinin repeats and/or a hemagglutination activity domain.
Links
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Statistics
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PSSM-Id: 410639
Aligned: 20 rows
Threshold Bit Score: 202.965
Created: 5-Sep-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PoNe conserved
Feature 1: PoNe conserved motif, 10 residue positions
Conserved feature residue pattern:K G [DE] G I D [FY] [FY] [DE] KClick to see conserved feature residue pattern help
Evidence:
  • Comment:conserved motif: Kx3GExnGIDx2YxnYx3ExK discovered in PoNe family members
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #   ##                           ###  #        #   # #                         
WP_060499442 2831 QKSIVGDLMGGERIQQ-IVPGAQKIGRAPdiGQTGIDDLYKVNKPDvDYLIVEYKFGSSTLkq-------tkDGMQMSDS 2902 Pseudomonas s...
WP_063939943 2766 QKRVMGELFGEHSVKN-LFPNGEKLARLQgtGSKGIDDLYRTNRPDvDFVVVEYKFGTSKLgh-------taDGIQMSDD 2837 Bordetella tr...
WP_139115344  131 QKRVVGEMFGENSIKS-TLPDGQKLARVQgsGTNGIDDLYRVDRPDvDFVVIEYKYGKSKLen-------tkDLMQMSDT 202  Xanthomonas c...
WP_123770759 3510 QKRVAGELFGENAIRT-WLPDANKIGRAQsaGTNGIDDLYKVNRPDvDYVIVEYKFGSSKLgt-------saDGPQMSDG 3581 Vulcaniibacte...
WP_081662839  802 QKGIMGELFGPNTVRR-IVPEGQKLARMSaiGETGIDDLYRVNRKDvDYVIIEYKFVGVDSktgasalsrtaDGKQGSES 880  Thermithiobac...
OGB81030      182 QKGAFGELFGENLVKQ-IVPDGQKLARSPgiGETGIDDLYKVNRPDvDYVHIEYKFVGNETtkgssrlgdtqDGKQGSES 260  Burkholderial...
WP_090143190 1275 QKRVIGENLFGPNTVKqIVPDGQQIARMQgqGSNGIDELYKVNRPDvDYVNIEYKFVGQDNktgaqvlkntnDGKQGSTS 1354 Limnohabitans...
WP_075929857  544 QKRVVAEVLGETTVQK-IVPRGEKLARSQgvGTNGIDDLYKVNHPDvDYVVIEYKFIGDYDkggssgliytkDGRQGSSN 622  Pseudomonas s...
WP_075571353   99 QKGEMGELFGPQTVKQ-IVPDGRKIARAHsaSEHGLDDLYQVNRPDvDYVVIEYKFVGTESktgasglgrtqDGRQGSES 177  Salinicola so...
TXH89793      101 QKRVIGEQLFGPNTVKqIVPEGKQLARMQgaGTNGIDELYKVNRPDvDYVNVEYKFVGTDRktgaqvlgntaDGKQGSTT 180  Rhodoferax sp.

Feature 1                                                                       
WP_060499442 2903 WLtgantnyNRVLESVSGDarearnirqalaaGRVEKWLVHTDPFGNVTVGVLDkaGKYVAD 2964 Pseudomonas sp. NBRC 111133
WP_063939943 2838 WLtgaksnfDRILDSVGGDvakardirkaldaGRVERWVVNTDPHGSVSVGIVDrmGKFIPK 2899 Bordetella trematum
WP_139115344  203 WLtgartgfNRIEEAVANPsiaadi-ssslgrNRVERWLVHTDPNGGVPSRLLIrrERLFRD 263  Xanthomonas campestris
WP_123770759 3582 WIlg----sNRLLNAVRSDkvaqdi-adairaGRVERWVVHTDPSGRVSVGMLDesGKFIPQ 3638 Vulcaniibacterium tengchongense
WP_081662839  881 WIlg----sGRLEKAVGSEkeanki-ydaiiaNRTETWVVATRPDGSTEIQVLDalGKPKAI 937  Thermithiobacillus tepidarius
OGB81030      261 WMlg----sGRLAKAVGEEnaiave--kavkaGRAETWVVTTRPGGATEIEVLDafGKPKPI 316  Burkholderiales bacterium RIFOX...
WP_090143190 1355 WIgg----sGRIEDAVGADnaidvd--kalrtGRVESWVVTVRPDGSTAVQVLDalGKPKPI 1410 Limnohabitans sp. DM1
WP_075929857  623 WTls----sERLENAVGQDraadiv--daiqmGRTETWVVTTTRNGSTEIQVLDslGRVKAV 678  Pseudomonas sp. PA1(2017)
WP_075571353  178 WImg----sDRLKKALGRSlvpeve--rafrnKRAEAWVIATRPDGATEVQVLDanGKPKAI 233  Salinicola socius
TXH89793      181 WIgg----sSRIENAVGAGknaddi-rdalklNRVESWVVTVRPDGSTAVQVLDglGKPKSV 237  Rhodoferax sp.

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