Conserved Protein Domain Family
CDI_toxin_Bp_tRNase-like
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cd20727: CDI_toxin_Bp_tRNase-like 
C-terminal (CT) toxin domain of a contact-dependent growth inhibition (CDI) system (CdiA-CT) similar to that of Burkholderia pseudomallei, and related proteins
CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the C-terminal (CT) toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via the C-terminal domain. A wide variety of C-terminal toxin domains appear to exist; this particular model contains the C-terminal (CT) toxin domains that are similar to Burkholderia pseudomallei E479 and 1026b CdiA toxins, both of which are tRNAses.
Links
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Statistics
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PSSM-Id: 412044
Aligned: 35 rows
Threshold Bit Score: 101.935
Created: 24-Sep-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative inhibitor binding site [polypeptide binding site]
Evidence:
  • Comment:CdiA protein binds neighboring bacteria and delivers C-terminal toxin domain (CdiA-CT) to inhibit target-cell growth; CdiI immunity protein specifically neutralizes cognate CdiA-CT toxin to prevent self-inhibition
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #                                ##         ###        ## ##  ##            
NP_248731    3414 PDANEVRAGQGLSGL--GYDVTHQTTASakgiqGQRTADLHVDgLGSIDVYTPknldpTKIVRAIEKKSNQa--gGVLVQ 3489 Pseudomonas a...
WP_091553118 2261 PSASEIAAAQHMAARg-GNVVLRDPVGTr---sGGMTSDLLVD-GVAWDVYSPtsgsvNNILTNIAKKHSQvnggGVVVD 2335 Micromonospor...
PTQ71231      451 PSVSELRAAEHMAGL--GRNVELRDPVGtr--aGGGTSDLLVD-GVPYDVYTPtsanpNRIISAVAKKNDQa--tGVVVD 523  Celeribacter ...
TWT29620      989 FSASERNAAQHMADL--GHDVTLRSPTGtr--aAGGTSDLLVD-GVRYDVYTPttnnpNRIIGAIAKKSSQaqggGVVLD 1063 Planctomycete...
OQW92108      164 FSESELRAAQYMATR--GHQVILRQPTGtr--iEGGTSDLLVD-GVRYDVYTPitdrpNRIISAIAKKNQQt--eGIVLD 236  Thiotrichacea...
SEU06738      168 FTQSEINSAYYMAAQ--GKKVELRSPVGtr--aGGNTSDLLVD-GVRYDVYTPttgnaDRIISAIAKKNTQt--eGVVLD 240  Pseudomonas s...
WP_145788265 3194 PSASEIAAAQHMAAR--GAKVLLRDPIGrr--sGGMTSDLLVD-GVAWDVYSPtsqtvKHILTSVAKKHSQv--nGGGVV 3266 Micromonospor...
WP_067502317 1191 PSASEREAAQYLADQ--GNQVTLRPPVGtk--aDGGTSDLIVN-GVRWDVYTPnsrnvKAILSKTAKKFTQvhggGVIVD 1265 Actinoplanes ...
WP_135240967 2086 PSASELAAASYAVSRtrGVVILRDPVGTr---aGGFTSDLVID-GAKWEVYSPtsanvKAILTNAAKKHSQvhggGVIID 2161 Micromonospor...
WP_123026149  342 FSASEREAAEELANR--GHDVLLRQADPs----AGRMSDLTLD-GVPYDVYTPrsgniDRLVGAIADKSSQvrggGIVLD 414  Mycolicibacte...

Feature 1                                                       
NP_248731    3490 ADLps---tDMSSIAARMWGkt--naQSIKT----------IFFQK 3520 Pseudomonas aeruginosa PAO1
WP_091553118 2336 LSGtg---lSVGQFGNALNRv----nGMIGSwgkr--piggLEFMG 2372 Micromonospora pattaloongensis
PTQ71231      524 LSNspvtreQLGDVLARVNGag---aTNITD----------IVIIG 556  Celeribacter persicus
TWT29620     1064 LSQttvtraQLGDVLKRVQGtg--asGVNDV----------VIIGG 1097 Planctomycetes bacterium Enr8
OQW92108      237 LTQttvtpaQLGNILCRVQGvg---aTNIKY----------IVIIG 269  Thiotrichaceae bacterium IS1
SEU06738      241 LSKss---vTREQLGDVLRRvngsgaKNIND----------VVIIG 273  Pseudomonas sp. NFR09
WP_145788265 3267 VDLggt-glAMSEFGNALGRv----nGMINSwgkq--pisgLEFIG 3305 Micromonospora sp. CNZ322
WP_067502317 1266 LRYtg---lSEVDFGPDPLKri---nGLIKSwghsd-fiseVKFIN 1304 Actinoplanes sp. TFC3
WP_135240967 2162 LTKtg---lTADQFPNATYRv----nSLIRSwgpdkqtmvgIEFIG 2200 Micromonospora sp. CNZ285
WP_123026149  415 LRNspltpeQVGDLLPRVRGi----tDKISD----------IIVIG 446  Mycolicibacterium sp. CECT 8783

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