Conserved Protein Domain Family
CdiA-CT_Kp-like

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cd20725: CdiA-CT_Kp-like 
CdiA C-terminal domain of the contact-dependent growth inhibition (CDI) system (CdiA-CT) similar to Klebsiella pneumoniae CdiA-CT
This family includes the C-terminal (CT) domain of bacterial CdiA, an effector protein involved in contact-dependent growth inhibition (CDI), a mechanism of inter-bacterial competition. The large CdiA effector protein carries a C-terminal toxin domain (CdiA-CT) which is delivered to neighboring bacteria to inhibit target-cell growth. Many of the domains in this family are associated with RHS repeats N-terminal to the domain. The exact biochemical function of this CdiA-CT is as yet unknown. CDI(+) bacteria also produce a CDI immunity protein (CdiI) to specifically neutralize the CdiA-CT toxins to prevent auto-inhibition. This CdiA-CT binds its cognate CdiI with high affinity.
Statistics
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PSSM-Id: 410972
Aligned: 13 rows
Threshold Bit Score: 157.875
Created: 15-Sep-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
SCY48468       99 LGNKLDYMLGKATGNkHNIQRSQAMQMELERIGIyDDIAGRDYLTQHLNKVVNDSsnisgvesrsyvakeicgqpimeyt 178  Pseudobutyriv...
EMG31507       57 LDDKLNYVFGKATGNqHNIQRSQSMQMELRKIGInDTPAFREYLSNHLNSVLHDSdsiikiekrsyiakellnkptieyt 136  Campylobacter...
KZK29016     5857 IGTKLEYFLGRATGSqHNIERSTGMLRQLESVGLpDSASTRQYLNHHLRTTFKDAssavri---------------qdng 5921 Delftia sp. G...
OCR00916       33 LGRKILYPLGKATGDrATIDRSQAMRRQLGAIGLaDTSDTRAYLSAHLYCVFHDRtniaei---------------qvng 97   Oscillatorial...
WP_037459597  205 IGTKLEYVFGKATGSaHNIERSTGMLRQLESVGIfDNAAGRSYLNSHLQGVYNSSkgilq-----------------sng 267  Sphingobacter...
OJG68202      306 LGNKLDYLFGKAKGNkHNIQRSQTMQSELSKIGIyDTPNSREFLNNHLKDAINDSsnilktetrsyvakelpglptvnyt 385  Enterococcus ...
WP_087712225  355 IGRKLLFAFGKAGGNnHNIRRSNDMLRQLESIGLhDNKENRAYVAQHLLSVYWDTtniken---------------qgrn 419  Phormidium sp...
PJJ26677      589 IGNKLDYVFGQATGSaHNIQRSQSMASELAHIGIqDTPANRALLQSHFESVGINLnniagtelrsy----iangqtfnyt 664  [Clostridium]...
AVK84465      539 FGSKLEFIFGNATGNkNHIERSLAMELQLNSIGIfDDAKGKKLVLDNLSNAFDDPssivkt---------------qdng 603  Lysinibacillu...
WP_106959411 2060 LGRKLEYFFGNATGSaHNRQRSGEMASQLNRIGVgDNAVGRAQFSQHLRDVFSDSgsvvgv---------------qeng 2124 Streptomyces ...
WP_115480792  290 IGNKLDYLFGKARGNkHNIERAKAMKKELSKIGIhDTSSGREYVSNHLKSLLNDStniskvetrsyvakelpgkpvvqyn 369  Robinsoniella...
RHP25383       57 LGNKLDYQFGKAGGNrHNIDRTNGLKAEMDKLGFnDTAENRAYFEQYYNDVLNSSnnivgdpetasy---iengvthyyt 133  Clostridium s...
RPD86154      236 IGTKLDYFLGRATGNqHNIDRSTGMLRQLESIGLpDNSVTRKYLSQHLRDAYTNPstivkv---------------qeng 300  Neisseria sp....
SCY48468      179 aTTRESFLMGqyGGVKLKTIWDGNRLLTVIIEGG 212  Pseudobutyrivibrio sp. AR14
EMG31507      137 aTVRESFLMGpmGGVKIESVWNGNKLLKIIAKGG 170  Campylobacter showae CC57C
KZK29016     5922 rVVRESLLMGphGGVKFETIWEGNRLITGEFFGP 5955 Delftia sp. GW456-R20
OCR00916       98 rIIKESLLMGpiGALKMKTVWDSNKLITIILFGK 131  Oscillatoriales cyanobacterium USR001
WP_037459597  268 rYLRESLLMGpnGGIKVESIWDGNRLITVKLLGG 301  Sphingobacterium spiritivorum
OJG68202      386 tTVRESFLKGpsGGVKIESVWDGDRLLTIIVKGG 419  Enterococcus moraviensis
WP_087712225  420 rVVKESLLAGprGFLKVESIWDVSNQKLVTVVLK 453  Phormidium sp. HE10JO
PJJ26677      665 aIIRESFFMGpsGGAGFRTVWEGYRLLTIIILGG 698  [Clostridium] celerecrescens 18A
AVK84465      604 rVVRETMISGpnGKLKVVSVWNKEKLVSVQLGED 637  Lysinibacillus sp. B2A1
WP_106959411 2125 rIVREGLFQGpgGMVKTKTVWEGDKLITGNLYGS 2158 Streptomyces sp. UNC401CLCol
WP_115480792  370 aTTRESLLMGpgGAVMVESVWDGNRLLTVIVKGG 403  Robinsoniella sp. MCWD5
RHP25383      134 vTTRESFLMGkyGGAKVTTYWDGNRLLTIKIGSG 167  Clostridium sp. AF34-10BH
RPD86154      301 rVVRETLLMGprGSVKFETIWDGNKLITGQIFGP 334  Neisseria sp. 10009
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