6CP9


Conserved Protein Domain Family
CdiA-CT_Kp342-like

?
cd20724: CdiA-CT_Kp342-like 
C-terminal (CT) domain of the contact-dependent growth inhibition (CDI) system (CdiA-CT) of Klebsiella pneumoniae 342 CdiA, and similar proteins
This family includes the C-terminal (CT) domain of Klebsiella pneumoniae CdiA, an effector protein involved in contact-dependent growth inhibition (CDI), a mechanism of inter-bacterial competition. The large CdiA effector protein carries a C-terminal toxin domain (CdiA-CT) which is delivered to neighboring bacteria to inhibit target-cell growth. The exact biochemical function of this CdiA-CT is as yet unknown. CDI(+) bacteria also produce a CDI immunity protein (CdiI) to specifically neutralize the CdiA-CT toxins to prevent auto-inhibition. This CdiA-CT binds its cognate CdiI immunity protein (all beta-sheet structure) with high affinity.
Statistics
?
PSSM-Id: 410971
Aligned: 48 rows
Threshold Bit Score: 143.852
Created: 15-Sep-2019
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:CdiA protein binds neighboring bacteria and delivers C-terminal toxin domain (CdiA-CT) to inhibit target-cell growth; CdiI immunity protein specifically neutralizes cognate CdiA-CT toxin to prevent self-inhibition
  • Structure:6CP9: Klebsiella pneumoniae CdiA toxin binds immunity protein CdiI; contacts at 4.0A

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1             #          # ### # ##                                    ### #        ###   
6CP9_A         15 VDAKKFDYLFGKATGNsHTLDRTNQLALEXKRLGVaDDINGHAVLAEHFTQATKd-sNNIVKKYTDq----yGSFEIRES 89   Klebsiella pn...
EIF38034      247 VDNQKYNYLFGNVKNDsHNTSRALQNKQQLSSIGIyDDRNGREIINKSLNEALSi-rNSVKDTYSKnidgkyHRFEAREG 325  Haemophilus p...
WP_112742852  493 LDDKKFDYFFGKVDSSdHNHYRSLQNQRQLNSIGIfDNEFGKSLLTGSINKQIQn-pSNVIDRREEihngvkQVFETREM 571  Moraxella bovis
WP_007530412 1504 VDDGKYDYIFGNVDSNpHNADRSVQNASQMMRIGIhDTVGGRALLLEHFNTVVAd-dSNILRTMSTe----yGDFQIRES 1578 Rhodococcus t...
SCF24176       66 VDPGKFDYMFGNVASNsHNAARSAQNQAQFARVGVyNNAEGRGLLQSHFDEVVGs-dSNILRTFKNe----hGEFQIRDS 140  Micromonospor...
OHT48797      125 IAPGKLDYIFGKVTSSpENMARSISMYKQLNAIGVfDNTAGRELVRQSLEAAAKstdNIVKEEVRNg-----VTTLTKES 199  Mycobacteroid...
AQA11144       94 IENGKWDYFFGRVNSNpHNAERSAQNAYQLESIGIrDNVAGREALTEHFNEAMR---NGVVETYVNpk--sgLTNMRTES 168  Streptomyces ...
PWK83986      621 VDNGKYDYLFGKVDSNsHNAARSKQNKEQLARIGVhDTPQGRALIKKHLDEAVTs-dANVKRTYTDe----yGTFQIRDS 695  Lechevalieria...
PXX66621      340 VDDKKFDYLFGKAADDpHNTPRSIQNQSQLNRVGVfDNPAGRDLLSRHFDEVIRs-dDNISRTFSTe----fGDFQVRES 414  Nocardia tene...
WP_122191508 2151 IQEGKYDYMFGRVDSNsHNTARSQQNMGQFMSIGIyDTPQGRAYIDQSLMDSLQs-nSSIVRAWCDq----yGDFEIRDS 2225 Nocardia sp. ...
Feature 1                       # #       # ##   #
6CP9_A         90 FFIGPsgKATVFESTFEVxkdGSHRFITTIPK 121  Klebsiella pneumoniae 342
EIF38034      326 IITGPg-GIRKFESHFEImndGSRRLTTIIFK 356  Haemophilus parainfluenzae HK262
WP_112742852  572 LLVGPn-GIRMMVVDFEImpnHSRRVTTIIIK 602  Moraxella bovis
WP_007530412 1579 VLAGPg-GFLKLESTWQEt-pDGFRLTTVIPR 1608 Rhodococcus triatomae
SCF24176      141 LFAGPg-GFLHLETTWQVt-gDRLRMTTVIPR 170  Micromonospora haikouensis
OHT48797      200 LLAGPn-GILKLQSFWEVt-sDGLRLTSVIPF 229  Mycobacteroides chelonae
AQA11144      169 LLYGPh-GALLIRANFEVt-dSGVRLTTMIPV 198  Streptomyces autolyticus
PWK83986      696 LFAGPg-GFLHFESAWQVt-pDGLRLTTIIPK 725  Lechevalieria deserti
PXX66621      415 LFAGPn-GILKFETTWQTt-pEGLRLTTVIPK 444  Nocardia tenerifensis
WP_122191508 2226 LLQGPtgGILKLESTWKLlpdGTYVLTTVIPM 2257 Nocardia sp. NEAU-LL90

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap