C-terminal (CT) domain of the contact-dependent growth inhibition (CDI) system (CdiA-CT) of Klebsiella pneumoniae 342 CdiA, and similar proteins
This family includes the C-terminal (CT) domain of Klebsiella pneumoniae CdiA, an effector protein involved in contact-dependent growth inhibition (CDI), a mechanism of inter-bacterial competition. The large CdiA effector protein carries a C-terminal toxin domain (CdiA-CT) which is delivered to neighboring bacteria to inhibit target-cell growth. The exact biochemical function of this CdiA-CT is as yet unknown. CDI(+) bacteria also produce a CDI immunity protein (CdiI) to specifically neutralize the CdiA-CT toxins to prevent auto-inhibition. This CdiA-CT binds its cognate CdiI immunity protein (all beta-sheet structure) with high affinity.