6CP8


Conserved Protein Domain Family
CdiA-CT_Ec-like
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cd20723: CdiA-CT_Ec-like 
C-terminal (CT) domain of the contact-dependent growth inhibition (CDI) system (CdiA-CT) of Escherichia coli CdiA, and similar proteins
This family includes the C-terminal (CT) domain of Escherichia coli CdiA, an effector protein involved in contact-dependent growth inhibition (CDI), a mechanism of inter-bacterial competition. The large CdiA effector protein carries a C-terminal toxin domain (CdiA-CT) which is delivered to neighboring bacteria to inhibit target-cell growth. The exact biochemical function of this E. coli CdiA is as yet unknown. CDI(+) bacteria also produce a CDI immunity protein (CdiI) to specifically neutralize the CdiA-CT toxins to prevent auto-inhibition. This CdiA-CT binds its all helical cognate CdiI with high affinity.
Links
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Statistics
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PSSM-Id: 410970
Aligned: 17 rows
Threshold Bit Score: 194.074
Created: 15-Sep-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 36 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:CdiA protein binds neighboring bacteria and delivers C-terminal toxin domain (CdiA-CT) to inhibit target-cell growth; CdiI immunity protein specifically neutralizes cognate CdiA-CT toxin to prevent self-inhibition
  • Structure:6CP8: Escherichia coli CdiA-CT binds CdiI immunity protein; contacts at 4.0A
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ###     #          #  #   #                     #  ##  ##  #      ##  ## ##
6CP8_A         4 FEVSSLPDanGKNHITAVKGDAKIPvDKIELYXRGKASgd--ldSLQAEYNSLKDARISSQKEFAKDpn-nAKRXEVLEK 80  Escherichia coli
OBY36049     146 SGIKWLPDahGKTHATIVKGDTAIPvDKIELYLRDKASgd--ltTLKADYNALKDLQVKNQSQFAKDln-nFDKLRILES 222 Providencia ret...
GDI35163      35 FDIEELPDahGKMHDTAVKGDAHIPkDKVERFMRGKASgn--ldELQQEYDELINLRRDNQRAFAKEypdgKKTIRALED 112 Escherichia coli
ODQ06547     171 FSIHSLPDahGREHITAVKGDAAIPvDKIEIWLRGKAKgd--leSLLVRQSVLINEKRDNQRAFAKDpn-kPKELGKIST 247 Shigella sp. FC130
WP_073279441 359 KTTEVTPPgsSHPVKVYTDGNAQINtGKIDTYMRGKVEld--vdAVKSRINELKNIKKTNTETFNKNm---KSELKSCED 433 Anaerocolumna j...
RHU87474     327 KIQAVIPPgsTHPVKVYTDGNAQINiGKIDTYIRGKVEld--veATITRIDELKDIRKLNPESFTKEm---KKELQECEN 401 Firmicutes bact...
WP_077853364 283 DIKEVTPPgaKNPVKVYTNGNAQVNkGKIDTYIRGKVEad--vnYLQGRIKELKRIKKANSSEFNKNl---AKELKDCEN 357 Clostridium aur...
PZT52018      43 TAKEVVAPssGKAIKVYTDGNTIIPiDKVEKYIRGRVNvn--iqEVNKELRELKQMRQTQRKIFDADpq-nTERIKRLDS 119 Paenibacillus s...
WP_027624776  92 NIEEVTPPgsQNPVKVYTDGYAQVNkGKIDAYIRGKIKkpenysELKDRIEELTKLKDTRPSEFTKEm---KNELKDINK 168 Clostridium lun...
WP_051957255  77 NVEEVTPPgsQNPVKVYTDGYAQVNkGKIDIYIRGKIKeppnyaELKNRIKELQKLKKQNPSEFTKEm---EKEFKAADK 153 Bacillus sp. UN...

Feature 1          ## ##  #  #                                ##                      ###      # 
6CP8_A        81 QIHNIERSQDXARVLEQAGIvNTASNNSXIXDKLLDSAQGAtsaNRKTSVVVSGp----nGNVRIYATWTILp-DGTKRL 155 Escherichia coli
OBY36049     223 KIHNVGKSRDMNKVLNNAGIpDTPLNNSMIINKLLKSANDVtatNRRTYIVINGs----kGNVRVYGTWTILp-DGSKRL 297 Providencia ret...
GDI35163     113 KMHNIDRSREMGQILEDAGIpDTPANNDMIIEKLLDSAQGDlpaDRTTSVVIDGk----nGSVRVNGVWVDMp-DGAKRL 187 Escherichia coli
ODQ06547     248 HIEGIGRSRTMGMDLEKIGFnDTKENNKFIIDKLLDTAKMVtpeNRWTSIVLKSqng-snESVRINAVWVILp-DGSKRL 325 Shigella sp. FC130
WP_073279441 434 KLHNYQRSQEMSKTLNNAGIlDNAENNQMIAEELLEAAKSAk--TGNTEIISYIkg--anGKIQVVSRWKILd-DGTPYL 508 Anaerocolumna j...
RHU87474     402 RLHNYQRSQEMNNTLNEAGIeDSIENNQMIVENLLDAAKEVt--DGNTEIISYIeg--vnGKVQVVSRWKILp-DGTPYL 476 Firmicutes bact...
WP_077853364 358 KLHNYQRSQEMSKTLNNAGIiDTAENNEKIAKNLLDAAKSVk--FDKTEVISYIeg--skGRVQIVSRWKILe-NSEPYL 432 Clostridium aur...
PZT52018     120 MKHNYERSDDMRKKLESIGLnDTPENNQSIAKHLLDVGKNI---TPENRLDFPStlkgskGRVKVLTTWSIV--DGKPYL 194 Paenibacillus s...
WP_027624776 169 KVHNYERSKGMGDLLNKAGIaDTVENNEMIANTVLDAAKEVk--AGNTKIVRYIkg---tNKDVIVESWWIIdsDGTPYC 243 Clostridium lun...
WP_051957255 154 IVHNYERSKGMGELLDDARItDTAENNEMIAKPVLDAAKEVt--SKNTKIRSYInv---gNKPVIVESWWILdkSGTPYC 228 Bacillus sp. UN...

Feature 1        ##   ###
6CP8_A       156 STVTGTFK 163 Escherichia coli
OBY36049     298 STLEAGAF 305 Providencia rettgeri
GDI35163     188 STIIVKVF 195 Escherichia coli
ODQ06547     326 STVTTGRF 333 Shigella sp. FC130
WP_073279441 509 ATVILKPI 516 Anaerocolumna jejuensis
RHU87474     477 ATVILKPM 484 Firmicutes bacterium OM08-11AC
WP_077853364 433 ATVILKPI 440 Clostridium aurantibutyricum
PZT52018     195 STIKLIPI 202 Paenibacillus silvae
WP_027624776 244 STIILKEV 251 Clostridium lundense
WP_051957255 229 STIILIEV 236 Bacillus sp. UNC322MFChir4.1

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