Conserved Protein Domain Family
CYCLIN_CCNO_rpt2

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cd20722: CYCLIN_CCNO_rpt2 
second cyclin box found in cyclin-O (CCNO)
CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410311
Aligned: 11 rows
Threshold Bit Score: 113.596
Created: 6-Sep-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P22674        231 PTISFFLEHFTHArveagq----aeaseaLEAQALARGVAELSLADyaftsYSPSLLAICCLALADRmlrvsrpv----- 301  human
Q32NJ2        246 PTINFFLQHFSLLrvtsvesp-dtelieaTKSMTVARGIAELSLADyafnaYSPSLVAACCLELADRmlclrnpi----- 319  African clawe...
Q32NM1        245 PTINFFLQHFSLLrvtneess-dtelsetTKSVTVARGIAELSLADyafnsYSPSLMAVCCLEIADRmlchrnpi----- 318  African clawe...
RMB95416     1203 PTVSFFLEHFSQVrlearg----adageaADARSLAAGVTELSLADyaftkYAPSLLAASSLGLADRllshrspl----- 1273 Hirundo rusti...
ELU02981      202 PTAQFFLEHHSSYrmrslit---sdkeafLRVRSLGRYLLELSLQDysicqYAPSLLAMGVLEVSDEvvsrtptg----- 273  Capitella teleta
XP_005998513  244 PTLGFFLDYFTNLrlenspepckggveeaRKAKCLARRMAELSLADyafnkYPSSLLAICSLRLVDQllhhqsppv---- 319  coelacanth
RXM92874      268 PTLAFFLEHFTKQrleggdelckrrlsesGQTKNLARTIAELSLADyafnrYPASLLAICSIRLADQmmdlhyti----- 342  sterlet
XP_023932424  175 PTTHYFLEQYSSSrlltrrla-gctkddiRKTRAIGRYLAEQSLQDydicqFLPSLVAICALEMADDllqhvtrv----- 248  Lingula anatina
XP_022334935  260 PTSQFFLEYFSSCvisnysg---fhadrlRQARSLARYLLELTLQDydlsqIRPSTLALCVWKSAVAhvntddgnflpdg 336  eastern oyster
XP_007890434  107 PGLDFFLEYYSEAsgegqe----vcsaraASTQGLARQIAQLSLADysfngYPPSLLAMAALRLAERmfqhqegt----- 177  elephant shark
XP_014775308  247 PTSLYFLEYYADVcirnadl---sciealKNSLATCRLVLELSLQDyqlsqIKPSLLSICLWLQNISnskeisgf----- 318  Octopus bimac...
P22674        302 ------------------dlrlgdhPEAALEDCMgKLQLLVAI 326  human
Q32NJ2        320 ------------------gvrvsgyHQSLIKECVgKIDLLVSL 344  African clawed frog
Q32NM1        319 ------------------rarvsdyHESLIQECVgKIDLLVSL 343  African clawed frog
RMB95416     1274 ------------------dlrvsgyPEELLRDCMdQLQLLVSL 1298 Hirundo rustica rustica
ELU02981      274 -----------------gvrstggySLQALEECItELRLLATA 299  Capitella teleta
XP_005998513  320 -----------------dllladeyPQSALQDCTdKLQLLVSL 345  coelacanth
RXM92874      343 ------------------sqdlsgyPQSVVEDCTeSLRLLVSL 367  sterlet
XP_023932424  249 -----------------ktawiagfNRDEIEKCLqHIRVMFSS 274  Lingula anatina
XP_022334935  337 lfftredfrlvyqevkvftenlqqsFPEIINICD-HYSNMYGQ 378  eastern oyster
XP_007890434  178 ------------------seqpnhdTACALEDCVeRLKLLVAL 202  elephant shark
XP_014775308  319 ------------------fvpneyySSSAFNDCFnKVSWLISN 343  Octopus bimaculoides
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