3T4R


Conserved Protein Domain Family
LNYV_P-protein-C_like

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cd20712: LNYV_P-protein-C_like 
C-terminal domain of lettuce necrotic yellows virus phosphoprotein and related domains
This family includes the C-terminal domain of the P protein of plant viruses belonging to the Rhabdoviridae family such as Lettuce necrotic yellows virus (LNYV). LNYV P protein acts as a weak local RNA silencing suppressor in plants to counteract RNA silencing antiviral defense. It suppresses both RNA induced silencing complex (RISC)-mediated cleavage and RNA silencing amplification. The C-terminal domain of LNYV P protein is essential for both local RNA silencing suppression and interaction with Argonaute (AGO) 1, AGO2, and AGO4 (key components of the RISC complexes), and with SGS3 and RDR6 (which function in the amplification step of RNA silencing). The family Rhabdoviridae belongs to the order Mononegavirales which are nonsegmented negative-stranded RNA viruses (NNVs). The genomes of NNVs are encapsidated by their nucleocapsid (N) proteins to form N-RNA complexes which serves as a template for transaction and replication. The C-terminus of P protein binds nucleocapsid. P protein plays multiple roles in transcription and translation, including acting as a chaperone of nascent nucleoprotein (N), and as a cofactor of the viral polymerase (L) where P forms a two-subunit polymerase with a large catalytic subunit (L) and stabilizes the polymerase on its template of N-RNA.
Statistics
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PSSM-Id: 411009
Aligned: 4 rows
Threshold Bit Score: 100.678
Created: 17-Aug-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3T4R_A         5 RHEKEKLLADLDwEIGEIAQYtPLIVDFLVPDDILAXAADgltPELKEKIQNEIIENHIALXALEEYSS 73  Lettuce necrotic yellows v...
YP_002308372 238 HHEKEKLMLDLGfEVDEVAGCdPLVLDMIITDDMLQVAAGgltEEIKEALQDQAIDNQMTIAQIVDIMK 306 Lettuce yellow mottle virus
AYH53269     236 YFEKEKLLIDLGfGLEDIAGYsPLAIDFIITDNMLEVASAgltEEIKDALQNQAIDNQIAVETMSDLMA 304 Red clover associated cyto...
Q9E7N7       232 RHEKEKLLADLDwEIGEIAQYtPLIVDFLVPDDILAMAADgltPELKEKIQNEIIENHIALMALEEYSS 300 Lettuce necrotic yellows v...
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