Conserved Protein Domain Family
MIX_IV
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cd20708: MIX_IV 
Marker for type sIX effectors domain, clan IV
This subfamily contains the MIX (Marker for type sIX effectors) IV clan (MIX IV) domain. MIX is a marker of type VI secretion system (T6SS) effectors carrying polymorphic C-terminal toxins. Predicted activity of the C-terminal toxin domains of Vibrionaceae MIX IV effectors is mainly pore-forming. Members of MIX IV are similar, in both sequence and synteny, to the Vibrio parahaemolyticus MIX-effector VP1388, but their activity is unknown. Notably, many toxins identified as T6SS effectors do not contain a recognizable delivery domain or signal, suggesting that additional delivery domains may exist.
Links
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Statistics
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PSSM-Id: 410949
Aligned: 93 rows
Threshold Bit Score: 83.1309
Created: 9-May-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CSC77497       23 CPFKQPLIGIIPVRYAFDVyddq--------gqalHPLPKADrqwkgqfsikQRSYTLRQLRDGWLYVYDE--------- 85   Vibrio cholerae
SHI71193       27 CPHMKKDIQLVPMRYAISEkdd----------qldKKLNGSLyq------dkAIPLGIRPLEAGWLYLIHSk-------- 82   Vibrio aeroge...
WP_090271859   35 CPARQAEIFVVPVRYALGEqa------------aeHANFQPGvt------psSHPMALRRLREGYLYIWHQd-------- 88   Pseudomonas l...
PWB29024       25 CPTSQAEIFVVPVRYALAEap------------laHPMCPPVep------laSHAMAARRLRCGYLYAWHHd-------- 78   Pseudomonas s...
KMN04051       35 CPASQPHLFVVPVRYALSEep------------asHPACQPGtq------tqSHPMAARLLRAGFVYVWQGr-------- 88   Pseudomonas h...
WP_069566648   23 CPARQAQLYIVPARYALAEqp------------akHPGLQPGvk------tnSHPMALRVLRAGFLYLWAGq-------- 76   Pseudomonas s...
WP_077334291   27 CPYMNPMIQLVPMRYAMSEe--------------gESVPENLndsl--yrddGVPQGFRPLNPGFLYIIHSe-------- 82   Vibrio ruber
WP_055103051   35 CQASPSQIFVVPVRYALGEepamrsefhpvvkaisHPAFQPGvt------thSHPMAARLLRSGFVYVWQGs-------- 100  Pseudomonas e...
WP_139832641   34 CPASQPDLFVVPVRYALAHek------------aeHACCVPGia------peSRPMATRRLRAGFVYVWQHqgplkryav 95   Pseudomonas s...
KJS73312       35 CPARQDEVFIVPVRYALAElaan--------htrcKPATKTH----------SHPMALRRLRPGYLYLWHDqgplrrfav 96   Pseudomonas s...

CSC77497       86 -TAKTLHEYEVv----------GCKLTKidwsddeankpthergskgesksCLLYPAQHTLSIGYAHQRWTWRVCEHMRS 154  Vibrio cholerae
SHI71193       83 -TPDKLYEYEVkadq----sltPRTFSKgdadfk------------aegkpQIIVPNTGSVKVMFTPLPLVPEAAEILLN 145  Vibrio aeroge...
WP_090271859   89 sQLKRYAIADD-----------GLLVEQgldapdap--------vpsgsqtGVALNKQYDAWLMFSEIPLPPSVHQLLAQ 149  Pseudomonas l...
PWB29024       79 gPLKRYAVAVD-----------GLLLEQpldapagl--------veagslrGLALDKHEEAWLCFSEHPIGPAQCAQLGA 139  Pseudomonas s...
KMN04051       89 gPLQRYAVAEN-----------NLLLSQgldeddtv--------vqsgtlsGLALAKQQDAWLLYSEIPLNPAACAELHD 149  Pseudomonas h...
WP_069566648   77 gPLKRYAVAKN-----------GLLQPQpldagrel--------pptgslaGVALDKGEDAWLLHTERPLGEQARAKLAK 137  Pseudomonas s...
WP_077334291   83 -DKETLYEFEVkddq----sliGRYFEKgtdafq------------dsgqkTIVVPRRGVLHALFMPVAMTPERAEILLG 145  Vibrio ruber
WP_055103051  101 gPLQRYAMAENhllraqaldddDTVVQFgt-------------------lsGIALDKHQEAWMLYSEIPLNPVACAQLSE 161  Pseudomonas e...
WP_139832641   96 sAEGLLQAQPLda--------gPALVADat-------------------laGLSLPKAHDAWMLYSEFPLGAEHCQALSE 148  Pseudomonas s...
KJS73312       97 aADGQLLEQGLdd--------pGSGVSSgs-------------------iaGIALNKQHDALLLYTEIPLTAAVHQRLTD 149  Pseudomonas s...

CSC77497      155 NTSSRHAVMR 164  Vibrio cholerae
SHI71193      146 ASSDQSELMN 155  Vibrio aerogenes CECT 7868
WP_090271859  150 SASERQGRMR 159  Pseudomonas litoralis
PWB29024      140 REVRAQYMRH 149  Pseudomonas sp. SDI
KMN04051      150 PQRRAKRMRL 159  Pseudomonas helleri
WP_069566648  138 PGGRRAHMRR 147  Pseudomonas sp. 1D4
WP_077334291  146 ASGDQSSLMN 155  Vibrio ruber
WP_055103051  162 PEIRAKRMRR 171  Pseudomonas endophytica
WP_139832641  149 DSAKRTQHMR 158  Pseudomonas sp. B26(2017)
KJS73312      150 EPSERRDRMR 159  Pseudomonas sp. BICA1-14
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