Conserved Protein Domain Family
MIX_III

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cd20707: MIX_III 
Marker for type sIX effectors domain, clan III
This subfamily contains the MIX (Marker for type sIX effectors) III clan (MIX III) domain. MIX is a marker of type VI secretion system (T6SS) effectors carrying polymorphic C-terminal toxins. No MIX III clan members have been detected in Vibrionaceae. Predicted activity of the C-terminal toxin domains of MIX III effectors is mainly pore-forming. Studies have shown that many members of the MIX III clan neighbor transposable elements. Notably, many toxins identified as T6SS effectors do not contain a recognizable delivery domain or signal, suggesting that additional delivery domains may exist.
Statistics
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PSSM-Id: 410948
Aligned: 199 rows
Threshold Bit Score: 49.7027
Created: 26-Aug-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_076413961  12 GLPILPTRYAVVPasfqqaelgtfsg------------------------------------------------------ 37   Achromobacter ...
WP_004816955  92 PKPTEPLRTITVSasrsakscfes-------------------------------------------------------- 115  Acinetobacter ...
WP_067554073  16 GLRVFLNRYILSNketknigiesslyktekekdllnsyfgstessv---------------------------------- 61   Acinetobacter ...
RYY78612      12 GVAIFLARYSIGShstyditktlpi------------------------------------------------------- 36   Moraxellaceae ...
WP_120401567  17 GLPIYLTRIGYNSsinrkliiakp-------------------------------------------------------- 40   Acinetobacter ...
WP_005196822  13 GLPLFISRFSVGRgsairspiakp-------------------------------------------------------- 36   Acinetobacter ...
WP_139739112  18 GLKIVIGRNTVSAgistatdlsgiyslndlklqqkiiideslrgifedinkiknkiaennlgnlskewktleekgnfkkv 97   Acinetobacter ...
WP_096735186 104 TIRVTATKGSYSYpkhkt-------------------------------------------------------------- 121  Acinetobacter ...
WP_087618916  16 GLVIMPIRYVAIPtssddyqitldevnheidalyaemvdfsfekqmvlseiideknqettsf----------------eq 79   Acinetobacter ...
WP_130070788  30 YVRLYLSLYGVYSksthksgilaplegnd--------------------------------------------------- 58   Bacteroides fr...
WP_076413961  38 ---------------------------------ervvdvkldaaryKYAVRTl--RHGFLYIFYEkgpqgaNYWEVYSVt 82   Achromobacter ...
WP_004816955 116 ------------------------------------insivppegyAYGLTTl--RAGYLYVFMKh----mDKWHEYEIs 153  Acinetobacter ...
WP_067554073  62 --------------kindagikelkiinmlaseegyknvygdkevdNYCYKGtilRRGYLYVYMEhl--qdKAWQEYEIs 125  Acinetobacter ...
RYY78612      37 -----------------------------------akkfpalpdsyHYTLQCl--QNGYLYIYDEld---kSSIRAFKIt 76   Moraxellaceae ...
WP_120401567  41 ------------------------------------anypdlsnqgSYELKSl-rNLGYIYVYDElk---pKELTCYSRh 80   Acinetobacter ...
WP_005196822  37 -----------------------------------agypelpasssYYTLRNl--RSGYLYIYDSl----dNSIKTYSLt 75   Acinetobacter ...
WP_139739112  98 fetglilsdntimhngaivvnadfkyrknpyyitkkqygitakgdnGYVVKSl--NPGYLYVYYEh----aKKIDEYMIs 171  Acinetobacter ...
WP_096735186 122 -----------------------------------------etsmeQYGFTGstlRKGFLYVYLKh----vNQWQEYKIs 156  Acinetobacter ...
WP_087618916  80 ssdnneqegstsegtsspptletitvkaskssysylnsineinapaGYGFAQsfmRLGYLYVYLEh----sNQLEEYIVs 155  Acinetobacter ...
WP_130070788  59 -------------------------------vssfpapkgfpdmkyGYSYQRiplRKGYIYAYFEkhn-taGIFKEYEVt 106  Bacteroides fr...
WP_076413961  83 a-dGMLWRCddtdsarlepsm---------kcanqghnplrMHYIVIEKpeqcgTVWLAFSEHKWSRQTLARYAS 147  Achromobacter xylos...
WP_004816955 154 q-qGFLKRIdnndyfsetisnsq-----skepcsktvhrarALMITIPKaseatEIYMKYSEVKWSKDKKVENKN 222  Acinetobacter guill...
WP_067554073 126 n-sGFLKRInehnffnindhsmlq--edekepcskivhranALTIFVPNpdeanNVYFKYSENKWSNERRAINKS 197  Acinetobacter larvae
RYY78612      77 ---GAYYTEvdlkyadaintsfek---khqacmqniqklsnAMLVAIPKpdvsrSIYISYSPYKWTKSTYENHIK 145  Moraxellaceae bacte...
WP_120401567  81 getNTLKVSqlsstnntick----------icstdgnrvlnGMLITLPQanskrNVWICFSAHKWTKKIIDNHIK 145  Acinetobacter sp. W...
WP_005196822  76 --aGGLATLinasepqaateafkk---qhvacmqqgqkyanAALITISKptvarSIFISYSEYKWTQAVLNAHRG 145  Acinetobacter sp. N...
WP_139739112 172 n-nGFLKKIngvndesillkk---------epcfsgdhlarSQTITIPKpeqatKLWLKYTEVKLSEKQKKIMIE 236  Acinetobacter berez...
WP_096735186 157 e-kGFLKRInesnydqdyssrplvlmeqgdepcmnikhranALTIVVPKpneasFVYLKYSENAWSKATKLRNKS 230  Acinetobacter guill...
WP_087618916 156 s-qGYLKKLlntkpnthpdt----------epcnnyghrqvSRTITIPHieeltNIYLCYSTVKWTEQVRANISN 219  Acinetobacter populi
WP_130070788 107 n-eGGIVNLvwsdmenpri------------swetpkkdrmTNYIVLRKqy-dkKVWLVFSPIRWSKQYAEKVLG 167  Bacteroides fragilis
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