Conserved Protein Domain Family

cd20703: FIX-like 
Found in type sIX effector (FIX) domain of unknown function
This family contains the Found in type sIX effector (FIX) domain and similar proteins. FIX is found N-terminal to known toxin domains and is genetically and functionally linked to type VI secretion system (T6SS), a widespread mechanism used by Gram-negative bacteria to antagonize neighboring cells. In Vibrio parahaemolyticus, it also co-occurs with C-terminal nuclease toxin PoNe (Polymorphic Nuclease effector) which is associated with several toxin delivery systems including type V, type VI, and type VII. FIX is present in various established T6SS-secreted effectors that have an N-terminal VgrG or PAAR or PAAR-like (i.e., DUF4280) domain, suggesting that FIX may play a role in delivery of T6SS effectors, and serve as a new marker for T6SS-delivered proteins to enable the identification of novel T6SS substrates.
PSSM-Id: 410939
Aligned: 5 rows
Threshold Bit Score: 72.8801
Created: 17-Aug-2020
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Q87PT6        270 WGAIMGDFNQDRSAGqiafdSAVTAIPFIdq-------igDGRDISANLYAfynaddiredkEKYTDLVITLVGFIPt-- 340  Vibrio paraha...
WP_069016016   33 FDAWLRDVSDGYVTLer-ikNVAGALPVVg---------nIIALVDALGDIvtlaeskkpdpWDWVSLGINLIGVIPvpp 102  Pseudomonas m...
SCL59977      444 LGMFAGDFAPKDSMAwlagnLCSGGLSFIpvvgwvlgglaDIRDTVAALIH-----------GDWVGAGLSILGLVPy-- 510  Micromonospor...
AIG25483      508 EKGFWGSLLDGVQLAl----DVVGMIPVVg----------IVADVANAGISva--------rGDYAGAALSLAACVPf-- 563  Brevibacillus...
TAK79305     2667 NQLLLGNYTEDVTLLgt-amQIGTGIVGVdl-------paDIRDLTHDVTHwew------twGHAGQTALDAIGLVPg-- 2730 Aquabacterium...
Q87PT6        341 aGSLIKGLFKE 351  Vibrio parahaemolyticus
WP_069016016  103 nMAAARMSLRP 113  Pseudomonas mosselii
SCL59977      511 aGDAVAIPGKA 521  Micromonospora chersina
AIG25483      564 aGAAATGAKLG 574  Brevibacillus laterosporus LMG 15441
TAK79305     2731 iGVVKNVDEAA 2741 Aquabacterium sp.
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