Conserved Protein Domain Family
MIX

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cd20701: MIX 
Marker for type sIX effectors domain
This family contains the MIX (Marker for type sIX effectors) domain, a marker of type VI secretion system (T6SS) effectors carrying polymorphic C-terminal toxins. MIX domains have been classified into five clans (called MIX I-V) by Dar et. al. based on sequence similarity. These domains have been further classified as either antibacterial or anti-eukaryotic, based on the presence or absence of adjacent putative immunity genes, respectively. In Vibrionaceae, antibacterial MIX-effectors carrying domains with pore-forming, phospholipase, nuclease, peptidoglycan hydrolase, and protease activities have been identified. Additionally, novel virulence MIX-effectors that employ a combination of antibacterial and anti-eukaryotic MIX-effectors have been found, suggesting that certain bacteria adapted their antibacterial T6SS to mediate interactions with eukaryotic hosts or predators. A subset of polymorphic MIX-effectors, a widespread class of effectors secreted by T6SSs, are horizontally shared between marine bacteria and used to diversify their T6SS effector repertoires, thus enhancing their environmental fitness.
Statistics
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PSSM-Id: 410945
Aligned: 10 rows
Threshold Bit Score: 96.0009
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CSC77497       29 LIGIIPVRYAFDvyddqgqalhplpka-drqwkgqfsikqrsYTLRQlrDGWLYVYDet----------aKTLHEYEVv- 96   Vibrio cholerae
WP_076413961   12 GLPILPTRYAVVpasfqqaelgtfsg--ervvdvkldaarykYAVRTlrHGFLYIFYekgp------qgaNYWEVYSVta 83   Achromobacter...
WP_094789851  389 VTAIYPVRFAYAnffeeslekaaeppsintmmgastiadgkgYVIRLlrQGWVYIREedd-------sanGHFHIFKYtk 461  Zooshikella g...
WP_106738111  112 WNQIVPVVPMTAlpgcrs------------------eqdlgaPVLVR--AGFVYVFYr-----------nKLWRELEVrq 160  Pseudomonas m...
RND31006      231 LEAFIPVVPSVQlg--------------------------erLGLPT--EGYYYHFYn-----------gRLVQEYKLlg 271  Vibrio cholerae
WP_016655979   32 LGQFLPVRIAVGfanggqgfaapae----ltaglptlpdsliYILRRldTGYLYCYSpawkt---thfndQGIRAYQVne 104  Acinetobacter...
WP_054580252   27 LGVDLPVRIGIGfknqvkecpshl------tknypnlpdnlvYTLRLleTGYLYVYAeawshdhhkqgleYPIRAYSIss 100  Acinetobacter...
WP_120429940   21 LGSFYPVRIAVAletensdnfkikdi---fanklpalpkglkYVYRRlnEGYLYAYAkewri---ghyndMNLHAYNVna 94   Acinetobacter...
WP_091641734  710 AVLVRPRRYAAAprdnadqpahdysgdnlrgpdqltelqrsrYVLDDlrEGYLYVLAn-----------eALACLYNTe- 777  Aquisalimonas...
WP_107493614   49 HVALLPVRYAVAqrtvrervtrytap---tlkrnlpainrasYVLRHlrAGMVYVFAr------------GKLHDFAVta 113  Thauera sp. D20
CSC77497       97 ---gCKLTKidwsddeankpt-----------------hergskgesksCLLYPAQh-------TLSIGYAHQRWTWRVC 149  Vibrio cholerae
WP_076413961   84 ---dGMLWRcddtdsarlepsm---------------kcanqghnplrmHYIVIEKpeq---cgTVWLAFSEHKWSRQTL 142  Achromobacter...
WP_094789851  462 teenGTVKEqfdkylfknklnaq------------gglvydssgsengyPFIFVKRsl-----kEVSIAYSEHEWHADVI 524  Zooshikella g...
WP_106738111  161 tdgkTTYHDvnvaryrdgtgf----------------rtglrrasgvalDDIWLPVqwnnrhtvDVQMCFSEIQLSAARL 224  Pseudomonas m...
RND31006      272 ---nGKWAFyatrstheqln-------------------deqgyniyqsAILVYWKlegk-dveNQHLIYLEQPITREEL 328  Vibrio cholerae
WP_016655979  105 ---lGYLTAidkdqmqvgfkeknytc------fqaqktskgqsisnaflLDCVVRQee----ssRVHIAYSRHQWSIDTC 171  Acinetobacter...
WP_054580252  101 ---nGYLSTipleniedhedvekthaicfetqeskkskgygdttinalhLDLYVGVd-------EIGIIYSRHQFSKTVI 170  Acinetobacter...
WP_120429940   95 ---nGFISAmdkdrmgvqpkakdyvc------finpvtskqktssnamlLDLFPNKdv----spVVDLFYSRHQLSIESC 161  Acinetobacter...
WP_091641734  778 ---dGQLVVvdgvdem--------------------------glgvhldALLVPENf------gTVRIAFSEHPWTDRQR 822  Aquisalimonas...
WP_107493614  114 ---gGHLRPhgaeaess-------------------------giliefaALLFPQSw------gEIYIAFSDHEWSPAQR 159  Thauera sp. D20
CSC77497      150 EHMR 153  Vibrio cholerae
WP_076413961  143 ARYA 146  Achromobacter xylosoxidans
WP_094789851  525 DKMN 528  Zooshikella ganghwensis
WP_106738111  225 QRLE 228  Pseudomonas mendocina
RND31006      329 DNLN 332  Vibrio cholerae
WP_016655979  172 NIMA 175  Acinetobacter rudis
WP_054580252  171 KKLE 174  Acinetobacter equi
WP_120429940  162 NQFE 165  Acinetobacter baylyi
WP_091641734  823 SRVL 826  Aquisalimonas asiatica
WP_107493614  160 RRAI 163  Thauera sp. D20
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