5T86


Conserved Protein Domain Family
CdiA-CT_Ec-like

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cd20692: CdiA-CT_Ec-like 
C-terminal (CT) domain of the contact-dependent growth inhibition (CDI) system (CdiA-CT) protein CdiA of Escherichia coli A0 34/86, and similar proteins
CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via the C-terminal domain. A wide variety of C-terminal toxin domains appear to exist; this particular model contains the C-terminal (CT) domain Escherichia coli A0 34/86 CdiA. Activity of this E. coli CdiA-CT is as yet unknown. CDI(+) bacteria also produce a CDI immunity protein (CdiI) to specifically neutralize the CdiA-CT toxins to prevent auto-inhibition. This CdiA-CT binds its cognate CdiI with high affinity.
Links
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Statistics
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PSSM-Id: 411005
Aligned: 47 rows
Threshold Bit Score: 103.031
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:5T86: Escherichia coli C-terminal domain of CdiA toxin (CdiA-CT) binds CdiI immunity protein; contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #                              #####                 ###   # ###       ### #   
5T86_A          2 EQILKPEk-nWETARNKALDLVGnlg-adSKPVIGRLevs--agnGKVIGRQSsDGKVGWRVDYDpekGTHINIWDYsqg 77   Escherichia coli
TAG95296     3910 IEIPRSYl-tAEAARNAALKEIGdlg-hdQVAIIGTLeks--kgyGKILGFESvDSTRGFRIDYDpnkGLHYNWYDYsqg 3985 Oscillatorial...
WP_002660793  255 IITITKVg-sRLDALKVVEGQVGdlg-kgAKPKMGKLvg----qkDRVTGMQSaDESRGWRIDYDpekGAHYNWWTE--- 325  Saprospira gr...
PDS23166      159 VTILKEGhetFENGVKVADDVIGglg-ddAVEKLGKFan----qkDKVVGFMSkDGKKGWRVDFDpkkGGHINWWNG--- 230  Flavobacteriu...
THU39401      313 IMTVTKTg-lRTDAYKVASAAIGdlg-ddAIPLMGKStskypdanKIVVGMQSaDGSRGWRIDFDpekGAHYNWFNNn-- 388  Niastella sp....
KPA11164     1431 HNGGAELfsdYNQASNAALSWLEkqgfkaEKVVLGKFgp----nkGKAIGMQTaEGKIGFRVEFDkrsGSHINVWSGk-- 1504 Candidatus Ma...
WP_133255162  117 RGAGTAFk-dFNQARNGAVQWLEgrgfkaEQATLGKFgd----naGKPIGMKSaDGKSGFRVEFDerhGAHINVWSG--- 188  Azoarcus comm...
EKF33717      181 VKATNKNk-sYEQSRNEALAWLEergfksEKQTFGKFgy----trNKPIGRQTeDGKIGFRIEHDsrsGAHINVWAGk-- 253  Bacillus xiam...
WP_131820385   13 IEHEKTFn-tLNEARDHARKMSGig--ddAVDFIQEIgp----skGRVSGRMSpDGKQGWRLDYDdkkGYHVNWWDQrg- 84   Cronobacter s...
WP_129038222  469 KKVGDDIi-dYHMARKEAFQWLEnrgfkaEKVVLGKFgt----skGKPVGMSTaDGKTGFRVEIDdrhGAHINVWFGk-- 541  Chryseobacter...
Feature 1                 ###       #           
5T86_A         78 k-gpgkAVKQVIPFeg-nEKSFETILKQLN 105  Escherichia coli
TAG95296     3986 kthtgfARKGSEEIvggtEEDFIKMIDQLN 4015 Oscillatoriales cyanobacterium
WP_002660793  326 ------KEKGAVPFeg-tERQVDQLIESLT 348  Saprospira grandis
PDS23166      231 ------NQKGAILIka-gENQIEQIIKNEI 253  Flavobacterium columnare NBRC 100251 = ATCC 23463
THU39401      389 -----tGERGAVFFeg-tADQVHYLKQQMT 412  Niastella sp. HX-2-15
KPA11164     1505 ------NKGPHFKFkg-nEKTLNKIVKRFA 1527 Candidatus Magnetomorum sp. HK-1
WP_133255162  189 ------KQKDTFTFeg-nQSMVDQIVKQFV 211  Azoarcus communis
EKF33717      254 ------EKGPHFEFda-sEKTVKKIQKHFR 276  Bacillus xiamenensis
WP_131820385   85 -----gPKRKDWLFg--aNKIENGTLDDYY 107  Cronobacter sakazakii
WP_129038222  542 ------EKGPHFTFda-tEKTINNIIKRFS 564  Chryseobacterium sp. CH21

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