Conserved Protein Domain Family

cd20689: CDI_toxin_Bp_tRNase-like 
C-terminal (CT) domain of the contact-dependent growth inhibition (CDI) system (CdiA-CT) of Burkholderia pseudomallei, and similar proteins
CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the C-terminal (CT) toxin domain of CdiA effector proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via the C-terminal domain. A wide variety of C-terminal toxin domains appear to exist; this particular model includes the C-terminal (CT) toxin domains of Burkholderia pseudomallei E479 and 1026b, both appearing to be RNAses acting on tRNA.
PSSM-Id: 412042
Aligned: 3 rows
Threshold Bit Score: 111.619
Created: 30-Sep-2020
Updated: 30-Sep-2020
Aligned Rows:
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:inhibitor binding site [polypeptide binding site]
  • Comment:CdiA protein binds neighboring bacteria and delivers C-terminal toxin domain (CdiA-CT) to inhibit target-cell growth; CdiI immunity protein specifically neutralizes cognate CdiA-CT toxin to prevent self-inhibition
  • Structure:5J4A: Burkholderia pseudomallei C-terminal domain of CdiA toxin (CdiA-CT) binds CdiI immunity protein; contacts at 4.0A
    View structure with Cn3D
  • Structure:4G6V: Burkholderia pseudomallei 1026a CdiA-CT domain binds CdiI immunity protein; contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1        #                               #             ###                     #  ##  #
5J4A_A      47 PGEAGAAAELENylggTLQRAPqg-------ssVDFVFSsgpnnGKTVDFMLTpdtvaqaakinqffdknlNNFMNTLSD 119  Burkholderia pse...
4G6V_A      64 IRENQSAVTLANkgydVVQNPEvlg-----pknPDYTIN-----GQVFDNYAPatg-------------nvRNIATTISN 120  Burkholderia pse...
NP_248731 3416 ANEVRAGQGLSGlgydVTHQTTasakgiqgqrtADLHVDg----LGSIDVYTPknl-------------dpTKIVRAIEK 3478 Pseudomonas aeru...
Feature 1      #                                            
5J4A_A     120 HAAaa--dFVPLASrflseaNKTLLVKAIGNlp-qKLQAKIILIK 161  Burkholderia pseudomallei
4G6V_A     121 KVSsgqasNIVVNLads-saSPAAIEAQINSyp-iPGLGKVIVID 163  Burkholderia pseudomallei 1026a
NP_248731 3479 KSNqa--gGVLVQAdlp-stDMSSIAARMWGktnaQSIKTIFFQK 3520 Pseudomonas aeruginosa PAO1

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