Conserved Protein Domain Family

cd20688: CdiI_Ecoli_Nm-like 
inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of Escherichia coli STEC_O31, Neisseria meningitidis MC58, and similar proteins
CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the inhibitor (CdiI, also called CdiI immunity protein) of the CdiA effector protein from Escherichia coli STEC_O31 Neisseria meningitidis MC58, and similar proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via its C-terminal domain (CdiA-CT). The CdiI immunity proteins are intracellular proteins that inactivate the toxin/effector protein to prevent auto-inhibition. They are specific for their cognate CdiA-CT and do not protect cells from the toxins of other CDI+ bacteria. Thus, CDI systems encode a complex network of toxin-immunity protein pairs that are deployed for intercellular competition. Neisseria meningitidis MC58 immunity protein CdiI has structural homology to the Whirly family of RNA-binding proteins, but lacks the characteristic nucleic acid-binding motif of the family. It has been predicted to neutralize toxin activity by preventing access to RNA substrates.
PSSM-Id: 412040
Aligned: 110 rows
Threshold Bit Score: 52.1445
Created: 30-Sep-2020
Updated: 25-Oct-2021
Aligned Rows:
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
  • Comment:CdiA protein binds neighboring bacteria and delivers C-terminal toxin domain (CdiA-CT) to inhibit target-cell growth; CdiI immunity protein specifically neutralizes cognate CdiA-CT toxin to prevent self-inhibition
  • Structure:5HKQ: Escherichia coli CdiI immunity protein binds CdiA; contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1        ##  #   #         #  ##      #####   ## #    ##            #  ###               
5HKQ_I        17 WTIRSYFDLXYne-nrFLDAVENIVn-kESYILDg--IYCNFPDXNSydes--ehfEGVEFAVGYppd-eddIVIVSEET 89  Escherichia coli
WP_048015925  16 ELMRLYYKIIGdg--kFMEAIENFKn-kQGFGIDp-vCCIFANEYQPgeee-yfgeTGVNFSIQPpmaeaeeTAIVDENV 90  Bacillus marisf...
WP_036153589  16 KNMEAYYNTLGyg--yFLEALNEFKn-gKGFGIGy-tSCYFATECTPndee-yfgdTGVNFTTTPpvtgtevHSIVDYKV 90  Lysinibacillus ...
WP_083335251  15 MPMCDYYSLIIkgpilFLGALESFSq-nQGFSVDy-hNCEFSHEMHPleee--yfaDGVRFTIDVsha-yesEVIVTFET 89  Planomicrobium ...
WP_101803067  14 TPMYDYFSFIMkgpilFLGAMRSFSq-nEGYSVDy-hNCEFSNEMHPleed--yfeDGIRFSIDIsha-yesEVIVSLDT 88  Planomicrobium ...
WP_014254852  16 SPMINYFNRLNdk--dFKEAITLFSk-dCGFGIDy-ySCSFASNWHPledg--yfeSGVQFVDSSggn--erKVIVDYAT 87  Hungateiclostri...
WP_083335331  14 VAMSAYYDQVIgspitFLEALRLFSq-nKGYSIDy-hTVELSLEMHPledd--yfpDGVRFSVDVpha-yeaEVIVSYKI 88  Planomicrobium ...
WP_120462791  11 TAMELYFLYLDed--kFVDALEDFSn-tVGYGISefiCCAFPSEYESweeg-yfgdTGVKFEVEPpavdeikYEIVSNTD 86  Paenibacillus a...
SES06306      36 GAVNDTFNEYVns-ncFLELLDDMKnklSDYNEGy--GMIFSDDYDDpndefyfgeNVICFYSGPdyd--dvEDIIGYEE 110 Lachnobacterium...
WP_106343035  16 KYMKAYFSTLGdn--yFLKALHHFKt-gKGFGIGy-tSCYFATECQPddee-yfgdSGVNFTTIPpvtnvevYAIVDYET 90  Laceyella sedim...
Feature 1                                      
5HKQ_I        90 CFEYVRLACEKYLQLHPe-dTEKVNKLLSK 118 Escherichia coli
WP_048015925  91 FFQYLTEAGEDYLTRRPq-dRTRVEVSLKE 119 Bacillus marisflavi
WP_036153589  91 FFEYLLKIAQEYLSIFPe-dKLIVEGDLAQ 119 Lysinibacillus odysseyi
WP_083335251  90 FYKYLLKVSDIYLEMHPq-dSQKVKRLLEI 118 Planomicrobium glaciei
WP_101803067  89 FYKYLSRACTFYLEIHPd-dSEEIKKLLEK 117 Planomicrobium sp. MB-3u-38
WP_014254852  88 FYKFLKMACDDYLEDHPe-eQNKVEEALKT 116 Hungateiclostridium clariflavum
WP_083335331  89 FYYYLSKVCILYLEMHPr-dSQEVKKLLSV 117 Planomicrobium glaciei
WP_120462791  87 FIDFLDKLTHQYLVSYPm-eQSKVELLLNQ 115 Paenibacillus aceti
SES06306     111 FYKYLVTACEFYVERRHpehKEIVEQKLKE 140 Lachnobacterium bovis
WP_106343035  91 FFRYLKEISEDYLTRYPd-eKGEVEACLEE 119 Laceyella sediminis

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