The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
Comment:based on related T-box transcription factors bound with DNA
Comment:T-box monomers dimerize upon DNA binding; some form weak dimers, others tight dimers, some may bind as non-associating monomers where the dimer is kept in register by the DNA
Lu S et al.(2020). "CDD/SPARCLE: the conserved domain database in 2020.",