5T6Q,6C94


Conserved Protein Domain Family
CYP4B_4F-like

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cd20659: CYP4B_4F-like 
Click on image for an interactive view with Cn3D
cytochrome P450 family 4, subfamilies B and F, and similar cytochrome P450s
This group is composed of family 4 cytochrome P450s from vertebrate subfamilies A (CYP4A), B (CYP4B), F (CYP4F), T (CYP4T), X (CYP4X), and Z (CYP4Z). Also included are similar proteins from lancelets, tunicates, hemichordates, echinoderms, mollusks, annelid worms, sponges, and choanoflagellates, among others. The CYP4A, CYP4X, and CYP4Z subfamilies are specific to mammals, CYP4T is present in fish, while CYP4B and CYP4F are conserved among vertebrates. CYP4Bs specialize in omega-hydroxylation of short chain fatty acids and also participates in the metabolism of exogenous compounds that are protoxic including valproic acid (C8), 3-methylindole (C9), 4-ipomeanol, 3-methoxy-4-aminoazobenzene, and several aromatic amines. CYP4F enzymes are known for known for omega-hydroxylation of very long fatty acids (VLFA; C18-C26), leukotrienes, prostaglandins, and vitamins with long alkyl side chains. The CYP4B_4F-like group belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410752
Aligned: 43 rows
Threshold Bit Score: 554.859
Created: 20-Sep-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                         #               ##      #   #      #           
5T6Q_A        56 PYAHPLWvgq-fiGFLNIYePDYAKAVYSRGDPKapdvydfflqwiGKGLLVLDGPKWFQHRKLLTPGFHYdvlkpYVAI 134 rabbit
AAS87604      61 DGLFSYCig--lyVCMELShPSPLSKLLSTAEPKdrisyrtikpwiGDGLLVSSGEKWARNRRLLTPAFHFdvlkpYVGI 138 Capitella capitata
XP_002739095  91 PYTGLLWfgp-fhGILICHhPDTIQPIMSTAEPKdeftygmvkpwlGDGLLISKGSKWFRNRRLLTPGFHFdilrpYVHI 169 Saccoglossus ko...
XP_022092268  79 MYALVFWvgp-fmPFVCVFhPDTVKTILKTSEPKsenmyrfvrpwiGDGLLLSTGKKWARNRRLLTPGFHFdilkpYVDI 157 crown-of-thorns...
XP_002586793  16 KDRCSVWrlgpflPVLSCShPDTVRPILGGKTQKtswvygffrpwlGDGLLISEGQKWQRNRRLLTPAFHFdilkhYVTL 95  Florida lancelet
XP_002611083  78 VYGYPVWfg--pvGYLNVThPEYTKTILATTEPKdefvyrfikpwiGDGLLVSHGQKWFRNRRLLTPAFHFgvlqpYTRL 155 Florida lancelet
XP_002124012  82 PVWTVNWfgp-yiSEVVIHhADLAITLLSSSAPKnnlvygffhpwiGDGLLTSSGRKWQRNRHLLTPAFHFsilkpYTNV 160 vase tunicate
XP_021363364  74 NGVFPVWmgp-ldAFLNMGhPSTVKHVLSGTDPKdesyal-mrpwiGDGLLLSGGRKWDRNRRMLTPAFHMdilkhYVEI 151 Yesso scallop
XP_002129693  82 PKLGMVWfgp-alAYLMVFhPHVVRPVLNVEHPKdnlayrfikpwiGDGLLVSHGSKWRRNRHLLTKAFHFdilkqYTKV 160 vase tunicate
XP_002121585  91 PAMCSQWlgp-aqMNVQLYhPDVTKTVLSKSYPKsyaynkflkpllRDGLVTSKGDLWKRHRRLLTPIFHFdilksHVQI 169 vase tunicate
Feature 1                                                                                        
5T6Q_A       135 FADSTRIMLEKWEkkacegk--sfdifsDVGHMALDTLMKCTFGkgdsg-lnhrdSSYYVAVSELTLLMQQRIDSfqyhn 211 rabbit
AAS87604     139 FSSTANIMADKWRkilsknd-eplemfqHVSLMTLDSLLKCIFGqtgsvqnegrdGSYIRSVYQLTELVMKRFQFfpyli 217 Capitella capitata
XP_002739095 170 FNECTHTMMDKWMkqsdng---miemfeHVSLMTLDSLLKCIFSieshcqtdvsrNPYITAVYALSEMVLKRVQFppyfs 246 Saccoglossus ko...
XP_022092268 158 FQESGGILVKKWQaacdgeekqsmemfsHISLLMLDSLLKCIFSvesnc-qtvedHPYIKGIYEIARLVGERFRFlpfhl 236 crown-of-thorns...
XP_002586793  96 FSESTQVLLEKWLsrgpga---svelfdQIGLMTLDNILKCSLGyhsncqtdgqsAPYIQAVHDLTSLIDERVDRplqhi 172 Florida lancelet
XP_002611083 156 FSDSTNIMMAKWRqlgaga---sidmfeHVSLMTLDSMLKCALTvesncqvdrkqNSYIAAVFSLTKLALQRFHLfplhs 232 Florida lancelet
XP_002124012 161 SNACVRVMLDKWSkkvgts----meiylDVNLMTLDTILQCAMStksdcqnrskkNEYIEAVHDVSKYIMSRVHKpllhi 236 vase tunicate
XP_021363364 152 FNESAKVLLGKWRenpgc-----vetfhHMSLLTLDSMMKCLFGhhsncqletvrPAYIQCVYDVSDLIIKRIMNplhhf 226 Yesso scallop
XP_002129693 161 FDACCKTMLEKWSrkcdgs---tvevfrPVSLMTLDSMLQCAIScetecqqegnsNAYTDAVFTLTTTAMKRIFNpfchv 237 vase tunicate
XP_002121585 170 FNQNSSRLLEWMEetsksdv--grdvavPDCDMAFNNVMECVMSkkssd-ltgetTRYTGYVQSVSAMMFQRLCQpilhs 246 vase tunicate
Feature 1                                                                                        
5T6Q_A       212 d----------fiywlTPHGRRFLRACRAAHDHTDRVIRQRKaalqdek------------------erekiqnRRHLDF 263 rabbit
AAS87604     218 dwiyyftpsalqvspmLQHCPRILAWSDSRQEGREEKKRSRRnq----------------------------vdSQNLDF 269 Capitella capitata
XP_002739095 247 d----------lvyhlTYSGYKWRRALRQVHGHSKTVIHQRKqalqdqk------------------klgikhnRKYIDF 298 Saccoglossus ko...
XP_022092268 237 d----------tvynlSPSGRRFHRAIESVHKYARDIIHQRRltlaaet------------------tnsktgqRKHVDF 288 crown-of-thorns...
XP_002586793 173 d----------fiyylTAKGRRFRQACKVVHSFSEQVIMTRKeerkkeelke------------edftspgyksGKCLDF 230 Florida lancelet
XP_002611083 233 d----------liyylTPMGYRFWKLCKVVHQHSESVIRDRRealkkeq------------------vqdsgqrRKYLDF 284 Florida lancelet
XP_002124012 237 d----------wiywlTAEGRKFKQLVKVLHDQSEKVIRERRktlenrk------------------feeessgKKRLDF 288 vase tunicate
XP_021363364 227 g----------flyslSENGRKFQYACDTIHEHSNKLIEQRRqllas-----------------------ekagSRNVDF 273 Yesso scallop
XP_002129693 238 d----------wifamTKSGRQFKAAAKLIHEFDEKVIRERRqenkkilgrsddedl--tqedlekitswrksdGRYLDF 305 vase tunicate
XP_002121585 247 d----------smfkvSGLGRRFAVAKKGIEDYANKIIIERRailssnspnselttttvkddvtgtsfnfnrrkGKMVDF 316 vase tunicate
Feature 1                                  #  ##  #                                              
5T6Q_A       264 LDILLDVRGEsgvqlSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYpeHQQRCREEVREILGdqds--fqweDLAKM 341 rabbit
AAS87604     270 LDILLDAKDSdgrglTDEEIQHEVDTFMFEGHDTTASGLSWCLYNLARHpeYQDRCRKEVMDVMGdrsd--vewdDMSKL 347 Capitella capitata
XP_002739095 299 LDILLEARDEsgkglTDQEIRDEVDTFMFEGHDTTASGISWILYNMAKHteHQLKCQEEIDELMDqkdkdeiewdDLSKL 378 Saccoglossus ko...
XP_022092268 289 LDILLCAKDTdgkglTDQEIFDEVDTFMFEGHDTTASGISWFLYNMARFpeFQQKCREEIDSLLAdrtddklhwdDLNNL 368 crown-of-thorns...
XP_002586793 231 VDILLQAKDEdgtglSVSEIRDEVNTFLFAGHHTTASGVSWTLFYLAQHqdYQDECRREAEGVLEgrte--itwhDVGKL 308 Florida lancelet
XP_002611083 285 LDILLKTKDEdgnglSDVEIRDEVDTFMFEGHDTTASGLSWTLYNLAKHpeHQERCRQEARSVLQgrsv--vnstDLSHL 362 Florida lancelet
XP_002124012 289 LDILLHTKDEdgkglNDSEIRDEVDTFLFAGHDTTASGIAWALYNLAVNvdCQDKCREELKSVVGdken--ieweDLSKL 366 vase tunicate
XP_021363364 274 LDILLTAKDSdgqglTDKEIRDEVDTFMFAGHDSTASTLSWCLYNLALHpeYQDRCREEVEREWGdktd--ltwdDIQKV 351 Yesso scallop
XP_002129693 306 LDMLILTRDDdgkglTEREIRDEVDTFLFEGHDTTASGIAWSLYCLAANeeYQEKCREEIEQVVGskda--lewqDLSKL 383 vase tunicate
XP_002121585 317 LDILIQTKDQdgvglTNDEINDEVITFFSAGHETVSNAITWSLYTLASNldCQTRCREEIKSAVGdket--lewaDLSKL 394 vase tunicate
Feature 1                       ##  #                                                            
5T6Q_A       342 TYLTMCMKECFRLYPPVPQVYRQLSKPVSFvd-------------------gRSLPAGSLISLHIYALHRNsdvWPDPEV 402 rabbit
AAS87604     348 TFLTMCIKESLRLHPAVPNIGRSLTKPMTFpd-------------------gRTVPAETDLGIAIYGCHHNsalWENPEQ 408 Capitella capitata
XP_002739095 379 PYLTMCIKESLRLHPPVPFIGRKLSKPIEMrspt--------------gkgkVVIPAGERIGIAITGLHHNqhvWEDPEV 444 Saccoglossus ko...
XP_022092268 369 PYLAQCLKESLRFHAPVYHIMRTLTQSVTFpd-------------------gRMIPKGISVAILISGLHHNknvWHDPET 429 crown-of-thorns...
XP_002586793 309 PFLTMCIKESLRCVPPVARSARTLQLDLTFad-------------------gKWLPKGTSAVADFPGLHRNseiWENPTV 369 Florida lancelet
XP_002611083 363 PYITVCIKESLRIHTAVPSIARKLTKSITFpd-------------------gKSLPPGSLVGISVWNIHHNphvWRDPKV 423 Florida lancelet
XP_002124012 367 SYLTLCIKESLRLCPPVPFIGRELNEPLKFrsklk-------------epneTTIDANSNIALHIFTLHRNvhvWDSPEE 433 vase tunicate
XP_021363364 352 SFTFSCIKESQRLFPPVPNVSRCAEKDITLpd-------------------gRVIPKGMRMAVSSFALHRNpdvWDNPEE 412 Yesso scallop
XP_002129693 384 PFVTMFIKEVLRLYPPVFAVARRTEQPVKFprgfggdqfnvgdeqlpksdcsRVVDAPLNIGIPIMTLHRNeqvWEDAKV 463 vase tunicate
XP_002121585 395 PYMTQCIKEAMRLFPTLHVVGRQLTEDVTLshrfn-------------dwkpVTLPKGSSIGVNIFAMNRNphiWDEPEK 461 vase tunicate
Feature 1                             ###   #####  ##   #                                        
5T6Q_A       403 FDPLRFSPenss-grhPYAFIPFSAGpRNCIGQQFAMNEMKVVTALCLLRFEfsVDPLRLPIKLp---qLVLRSKNGIHL 478 rabbit
AAS87604     409 YDPERFNAensk-drpPHSFIPFSAGpRNCIGQHFAMHEMRSVLAVCLKNFQlrIDDTRILELLp---qLVLKAKGGLWL 484 Capitella capitata
XP_002739095 445 YNPLRFTPenck-grsPHAYLPFSAGpRNCIGQNFAMNEMKIAVGLVLRKFNlaVDDFIRIRRYn---sIVLRGERGIPL 520 Saccoglossus ko...
XP_022092268 430 FDPERFAPeriq-sipTYAYVPFSAGpRNCIGQHFAMSEMKVVATIILRNFYlsVDESVPVLRRn---aLVLRADNGINL 505 crown-of-thorns...
XP_002586793 370 YDPYRFSPense-rrpPHAFLPFSAGpRNCIGQNFAMNEMKVTLALTLQRFR--LEPDVTKPPVipcdgITLQARGGIWV 446 Florida lancelet
XP_002611083 424 YDPSRFLPenck-grhSHAFIPFSAGpRNCIGQHFAMNELKTAVALIVQSFRlsVDENHVAKGVm---sLVLKAAEPGLF 499 Florida lancelet
XP_002124012 434 FIPERFKPenmk-grsPHAYLPFSAGpRNCIGQNFAMNEMKIAIGQTLRKFKviPDESFPKPSItp--qVVLRPKDGIFI 510 vase tunicate
XP_021363364 413 YDPSRFSEqnkkinagSGSFIPFSMGpRNCIGQAFATTQLKVVIPTIIRNFRltLDPTRPAEPEa---mLILRSKNGLYL 489 Yesso scallop
XP_002129693 464 FDPYRFSTenca-krsPYAYLPFSAGpRNCIGQNFAMAELKTVLVRTLLKYKlyVDNQCPDPKMsp--mIVLKSLNGIHI 540 vase tunicate
XP_002121585 462 FDPERFSPdnta-nrsPHAFIPFGAGpRNCIGQNFGMQQIRVVLSKVLRKYEvyVDETLPKPVMvp--gVAMQPKNGVYI 538 vase tunicate
Feature 1         
5T6Q_A       479 Y 479 rabbit
AAS87604     485 K 485 Capitella capitata
XP_002739095 521 H 521 Saccoglossus kowalevskii
XP_022092268 506 Y 506 crown-of-thorns starfish
XP_002586793 447 K 447 Florida lancelet
XP_002611083 500 L 500 Florida lancelet
XP_002124012 511 K 511 vase tunicate
XP_021363364 490 N 490 Yesso scallop
XP_002129693 541 K 541 vase tunicate
XP_002121585 539 K 539 vase tunicate

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