Conserved Protein Domain Family
CYP5A1

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cd20649: CYP5A1 
cytochrome P450 family 5, subfamily A, polypeptide 1, also called thromboxane-A synthase
Cytochrome P450 5A1 (CYP5A1), also called thromboxane-A synthase (EC 5.3.99.5) or thromboxane synthetase, converts prostaglandin H2 into thromboxane A2, a biologically active metabolite of arachidonic acid that has been implicated in stroke, asthma, and various cardiovascular diseases, due to its acute and chronic effects in promoting platelet aggregation, vasoconstriction, bronchoconstriction, and proliferation. CYP5A1 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410742
Aligned: 4 rows
Threshold Bit Score: 856.06
Created: 3-Oct-2017
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #             ##      #   #      #         
P24557     73 LYGPLCGYYLGRrMFIVISePDMIKQVLVENFsnFTNRMASGlefKSVADSVLFLRdKRWEEVRGALMSAFSpeKLNEMV 152 human
AAQ97855   77 KYGRICGYYIGRrSTVIIAdPDMLRQVMVKEFnkFPNRMTARgitKPMSDSLIMLKgEQWKRVRSILTPTFSaaKMKEMV 156 zebrafish
AAH59313   71 TYGPICGYYMGRrPMIVIAePDAIKQVLQKDFvnFTNRMKFNlatKPMSDSLLCLRdDKWKRVRSVLTPSFSaiRMKEMC 150 African clawed frog
XP_416334  76 EYGPVCGYYIGRqMFVVIStPEVIKQILVTDFgnFTNRTKPNlisKPMLDSILCLRdERWKYVRSLLTPAFSdaKLKEMI 155 chicken
Feature 1                                                                                     
P24557    153 PLISQACDLLLAHLKRYAesgdafdIQRCYCNYTTDVVASVAFgtpvDSWQAPEDPFVKHCKRFFEFCIPrp-ilVLLLS 231 human
AAQ97855  157 PLINTATETLLRNLKSHAesensfnIHKCFGCFTMDVIASVAFgtqvDSQNNPDDPFVHQASKFFAFSFFrp-imIFFMA 235 zebrafish
AAH59313  151 PLINQCCDVLVDNLQEYAssgeacnVQRCYACFTMDVVASVAFgtqvDSQKDPEHPLVQNCKRFLEQFTPfkplvLLCLA 230 African clawed frog
XP_416334 156 PLINQACDVLLSNLKVYAdsgrafdIQRCYNCFTLDVVGSVAFgtevDSQKNPDDPFVKNCRTFFEMSLFkp-llFLILS 234 chicken
Feature 1                                                                                     
P24557    232 FPSIMVPlariLPNKNRDELNGFFNKLIRNVIALRdqqaaeeRRRDFLQMVLDARHSASPMGVQDFDivrdvfsstgckp 311 human
AAQ97855  236 FPFLLRPlaglLPNKSRDEMNSFFTQCIQKMIKQRddlspeqRRKDFLQLMLDVRTNNKFLSVEHFDvvndadeeaydgh 315 zebrafish
AAH59313  231 FPSIMIPiarrLPNKQRDRINSFFLKVIRDIIAFRenqppneRRRDFLQLMLDARDSAGHVTVDHFDivnqadlsvprns 310 African clawed frog
XP_416334 235 FPFIMIPllriLPNKKQKELNGFFIQTIKNAIAFRdqqdaaeRRRDFLQWMLDSRNSADALAGGYFDqicpattsshnev 314 chicken
Feature 1                                   #  ##  #                                          
P24557    312 np----srqhqpspmarpltVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHmapefcsle 387 human
AAQ97855  316 ens-panestkrsqqkrmmtEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHemvdya-nv 393 zebrafish
AAH59313  311 psekqdrgqdsprkstkklnEEEILGQAFIFLIAGYETTCSLLSFASYLLATHPECQKKLLREVDEFGREHkeadyn-tv 389 African clawed frog
XP_416334 315 pl----vdktpsekaqkmltEDEIAGQAFLFLIAGYETTTSTLSFATYLLATNPECQEKLLQEIDEFSAKHtitdyq-nv 389 chicken
Feature 1                           # #                                                       
P24557    388 eglpYLDMVIAETLRMYPPaFRFTREAAQDCEVLgQRIPAGAVLEMAVGALHhDPEHWpSPETFNPERFTAEArqqhrPF 467 human
AAQ97855  394 qelkYLDMVICESLRLYPPaFRVARDVEEDTVLNgQFLPKGASLEIPTGFLHyDPEHWtEPTKFIPERFTPEAkarrhPF 473 zebrafish
AAH59313  390 helpYMEMVINETLRMYPPaYRFAREAARDCTVMgLNIPAGAVVEIPIGCLQnDPRFWhEPEKFNPERFTAEEkqkrhPF 469 African clawed frog
XP_416334 390 qelpYLDMVIAETLRMFPPaFRFTREAAKDCVVLgQRIPAGAVIETAVGHLHhNPEFWpEPEKFIPERFTEEAkkerhPF 469 chicken
Feature 1        ####  #####   #                                          
P24557    468 TYLPFGAGpRSCLGVRLGLLEVKLTLLHVLHKFRFqacpETQVPLQLEskSALGPKNGVY 527 human
AAQ97855  474 VYLPFGAGpRSCVGMRLAQLEIKVALVHIFRRFNVlaceDTEIPLELKshTTLGPKNGVM 533 zebrafish
AAH59313  470 LFLPFGAGpRSCIGMRLALLEAKITLYRILKNFRFqtcdLTQIPLQLSamSTLRPKDGVY 529 African clawed frog
XP_416334 470 AYLPFGAGpRGCIGRKMGLLATKMTLLRILQMFRFktcpETEIPLQLKskATLGPKNGVY 529 chicken

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