Conserved Protein Domain Family
CYP26A1
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cd20638: CYP26A1 
cytochrome P450 family 26, subfamily A, polypeptide 1
Cytochrome P450s 26A1 (CYP26A1) is a retinoic acid-metabolizing cytochrome that plays key roles in retinoic acid (RA) metabolism. It is the main all-trans-retinoic acid (atRA) hydroxylase that catalyzes the formation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. RA is a critical signaling molecule that regulates gene transcription and the cell cycle. CYP26A1 has been shown to upregulate fascin and promote the malignant behavior of breast carcinoma cells. It belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Links
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Statistics
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PSSM-Id: 410731
Aligned: 6 rows
Threshold Bit Score: 886.081
Created: 25-Mar-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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heme bindingchemical
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of Synechocystis sp. CYP120A1 with bound heme (2VE3)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                 #            ##      # 
O43174        55 GETLQMVLQRrKFLQMKRRKYGFIYKTHLFGrPTVRVMGADNVRRILLGEhrlvSVHWPaSVRTILGsgcLSNLHDSSHK 134 human
O93323        55 GETLQMVLQRrRFLQVKRSQYGRIYKTHLFGsPTVRVTGAENVRQILMGEhklvSVHWPaSVRTILGagcLSNLHDNEHK 134 African clawed ...
Q9PUB4        55 GETLQMVLQRrKFLQMKRRKYGFIYKTHLFGrPTVRVMGAENVRHILLGEhrlvSVQWPaSVRTILGsgcLSNLHNGQHK 134 chicken
P79739        55 GETLQLILQRrKFLRMKRQKYGCIYKTHLFGnPTVRVMGADNVRQILLGEhklvSVQWPaSVRTILGsdtLSNVHGVQHK 134 zebrafish
XP_007894797  55 GETLQLVLQRyKFLKMKVQKYGYIYKTHLFGsPTVRIMGAENVKQILLGEhklvSVQWPaSVRTILGaacLSSLHDSEHK 134 Callorhinchus m...
XP_005991616  55 GETLQMILQRrKFLQMKRKKYGYIYKTHLFGrPTVRVMGAENVRQILLGEhrlvSVQWPaSVRTILGsgcLSNLHDSQHK 134 Latimeria chalu...

Feature 1          #      #                                                #                     
O43174       135 QRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCgerglLVYPEVKRLMFRIAMRILLGcepqlagdgdSEQQLVEAF 214 human
O93323       135 YTKKVIAQAFSREALANYVPQMEEEVRCSVNLWLQSgp-cvLVYPAIKRMMFRIAMRLLLGcdpqr-mdreQEETLLEAF 212 African clawed ...
Q9PUB4       135 HRKKVIMQAFSRDALQHYVPVIQEEVSACLAQWLGAgp-clLVYPEVKRLMFRIAMRILLGfqprq-aspdGEQQLVEAF 212 chicken
P79739       135 NKKKAIMRAFSRDALEHYIPVIQQEVKSAIQEWLQKds-cvLVYPEMKKLMFRIAMRILLGfepe--qiktDEQELVEAF 211 zebrafish
XP_007894797 135 HRKRVILKAFSREALQNYIPVMSEEIRAGVRGWLEGap-rvLVYPEMKRIMFGIAMRILLGfepaq-tnrgTQEQLIEAF 212 Callorhinchus m...
XP_005991616 135 HRKKVIMKAFSRQALENYIPVIVEEVRSAVCQWLSSgs-cvLVYPEVKRLMFRIAMRILLGfepqq-tkpeNELQLVEAF 212 Latimeria chalu...

Feature 1                                                                                        
O43174       215 EEMTRNLFslPIDVPFSGLYRGMKARNLIHARIEQNIRAKICglraseagqgcKDALQLLIEHSWErgerlDMQALKQSS 294 human
O93323       213 EEMSRNLFslPIDVPFSGLYRGLRARNLIHAQIEENIKEKLQrepd----ehcKDALQLLIDYSRRngepiNLQALKESA 288 African clawed ...
Q9PUB4       213 EEMIRNLFslPIDVPFSGLYRGLRARNIIHAKIEENIRAKMArkep---eggyKDALQLLMEHTQGngeqlNMQELKESA 289 chicken
P79739       212 EEMIKNLFslPIDVPFSGLYRGLRARNFIHSKIEENIRKKIQdddne-neqkyKDALQLLIENSRRsdepfSLQAMKEAA 290 zebrafish
XP_007894797 213 EEMIRNLFslPIDVPFSGLYRGLKARNVIHAKIEENIRKKMAkrdt---sdqfKDVLQLLIEHSQKddeplRLQELKESA 289 Callorhinchus m...
XP_005991616 213 EEMIRNLFslPIDVPFSGLYRGLKARNVIHEKIEENIKAKLTkpnt---etqhKDVLQLLIEQYEKngeqlNMQELKESA 289 Latimeria chalu...

Feature 1         ##  ##  ##                                                           #    ##   
O43174       295 TELLFGGHETTASAATSLITYLGLYPHVLQKVREELkskgllcks-nqdnkldmEILEQLKYIGCVIKETLRLNPPVPGG 373 human
O93323       289 TELLFGGHGTTASAATSLTSFLALHKDVLEKVRKELetqgllstkpeekkelsiEVLQQLKYTSCVIKETLRLSPPVAGG 368 African clawed ...
Q9PUB4       290 TELLFGGHETTASAATSLIAFLGLHHDVLQKVRKELqlkgllsgp-nqekqlnmEFLEQLKYTGCVIKETLRLSPPVPGG 368 chicken
P79739       291 TELLFGGHETTASTATSLVMFLGLNTEVVQKVREEVqekvemgmy-tpgkglsmELLDQLKYTGCVIKETLRINPPVPGG 369 zebrafish
XP_007894797 290 TELLFGGHETTASTATSLVMFLGLHPEVVRKVRKELqeqgllssdaqenkhitiEVLEQLKYTGSVIKETLRLSPPVPGG 369 Callorhinchus m...
XP_005991616 290 TELLFGGHETTASAATSLITFLGLHHEVLEKVRKELktkellcehhkdnkyldmEVLEQLKYTGSIIKETLRLSPPIPGG 369 Latimeria chalu...

Feature 1         #                    # #                                    ###   # ###  ##   #
O43174       374 FRVALKTFELNgYQIPKGWNVIYSICDTHdVAEIFtNKEEFNPDRFmlphped-asrfsfIPFGGGLRSCVGKEFAKILL 452 human
O93323       369 FRVALKTFVLNgYQIPKGWNVIYSIADTHgEADLFpDTDKFNPDRFltplprd-ssrfgfIPFGGGVRCCIGKEFAKILL 447 African clawed ...
Q9PUB4       369 FRIALKTLELNgYQIPKGWNVIYSICDTHdVADLFtDKDEFNPDRFmspsped-ssrfsfIPFGGGLRSCVGKEFAKVLL 447 chicken
P79739       370 FRVALKTFELNgYQIPKGWNVIYSICDTHdVADVFpNKEEFQPERFmskgled-gsrfnyIPFGGGSRMCVGKEFAKVLL 448 zebrafish
XP_007894797 370 FRVALKTFVLNgYQIPKGWNVIYSICDTHdIAEIFsKKDEFNPDRFmegclekdssrfgyIPFGGGSRSCVGKEFAKVLL 449 Callorhinchus m...
XP_005991616 370 FRVALKTFELSgYQIPKGWNVIYSICDTHdVADIFsNKQEFNPDRFmssyped-ssrfsfIPFGGGSRSCVGKEFAKILL 448 Latimeria chalu...

Feature 1                                              
O43174       453 KIFTVELARHCDWqLLNGPPTMktsPTVYPVDNLPARF 490 human
O93323       448 KVFVVELCRNCDWeLLNGSPAMttsPIICPVDNLPAKF 485 African clawed frog
Q9PUB4       448 KIFTVELARSCDWqLLNGPPTMktgPIVYPVDNLPAKF 485 chicken
P79739       449 KIFLVELTQHCNWiLSNGPPTMktgPTIYPVDNLPTKF 486 zebrafish
XP_007894797 450 KIFTVELVRTCDWeLLNGPPTMktsPTVYPVDNLPTKF 487 Callorhinchus milii
XP_005991616 449 KIFTVELASSCDWqLLNGPPTMktgPTVYPVDNLPTKF 486 Latimeria chalumnae

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