Conserved Protein Domain Family
CYP_unk

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cd20624: CYP_unk 
unknown subfamily of actinobacterial cytochrome P450s
This subfamily is composed of uncharacterized cytochrome P450s. Cytochrome P450 (P450, CYP) is a large superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop. Their monooxygenase activity relies on the reductive scission of molecular oxygen bound to the P450 heme iron, and the delivery of two electrons to the heme iron during the catalytic cycle.
Statistics
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PSSM-Id: 410717
Aligned: 7 rows
Threshold Bit Score: 473.486
Created: 18-Aug-2017
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                  #   #      #       
CAM01397   68 YGAGPLRLRVPgRDVVLVLSPEHVRRVLVSDAESFTPANREKqaalghfqphgvllsrglDRARRRQFHEHVLEtrehah 147 Saccharopolyspora ...
ADB32875   60 YGEGPLLLRLPgRKLALALDPDHVRRLLAETPEPFSAATSEKvgalrhfqphavlvtdppLRVPRRDLNEQALDahrp-v 138 Kribbella flavida ...
ABK75075   60 FGRGPVELVIPgRRIVVVTDPEDVAAVLVQAPEPFHPANREKrkalqwfqphgvlisqgpIREQRRTVNEAALDsgaamh 139 Mycobacterium smeg...
ACY97998   67 YGPGPLRLAVPgRRLVLPLLREDVRRLLADSSGRFTPAIDARakvpprlqahgvpapageDRQRRRRADETVLDtyqvvh 146 Thermomonospora cu...
ABC93947   67 YGPAPLLLPIPlRPQLLILDSADVATVLQSSPEPFAAATMEKhaalvhfepenllissnsRRAELRPAHEHALAtadrlh 146 Rhizobium etli CFN 42
ACS60666   80 YGRGPLLVPLPfRPQLLLLDPHHVAEALEGTPMPFTPASKEKrsalahfepgnvlisnaaRRAELRPLHEHALAtnervh 159 Rhizobium legumino...
ACU95316   57 YGPGPVWLRVPgRSIALLLDPDDVDRVLTSTPSPFSPAAREKraalnhfephgalvtpasERAPRRRYNERVLEsdrpvh 136 Saccharomonospora ...
Feature 1                                                  #                                  
CAM01397  148 hlAPRFIQVVREEARVLLDEAErtgs-ldwqTFGAGWWRVVRRIVLGDQARDDreltgeLDALRSDANWAFLSPkrlslR 226 Saccharopolyspora ...
ADB32875  139 hrSGHTMVAVITEELDRLDGTLgw------nDFRALWMRITRRIVLGDAAADDeeltdlLDALRADANWAQFRRrdstaQ 212 Kribbella flavida ...
ABK75075  140 rlAESFAAKVAAEADTLVARTLpgqr-ldadEFMTAWWRLVRRLTLGERARDDhaitdqLARLRRAGNWSFLSLphyraR 218 Mycobacterium smeg...
ACY97998  147 rlAGPFMVRIYQEAAALLGGERsagreltwrEFSAAFGRLGRRLVLGDSAREDrmltelLARTATGRRRRGGREri--aA 224 Thermomonospora cu...
ABC93947  147 pyAMHFKNIVDAEFLQILKLPReld----wpAFSQAWFRIVRRVVLGERARKDvtltetLDELRGRANWAFAAPv----D 218 Rhizobium etli CFN 42
ACS60666  160 pfVEHFDRIVREELQALLPLADtgvryvswdEFSQPWFRIVRRIVLGDSAREDeqltndLDDLRRRANWAFAAFanngkL 239 Rhizobium legumino...
ACU95316  137 clAGRVRGIVGEETRLLLTTTTeld----wrHHARTWWRIVRRLVLGDHTRDDagitdeLAALRMRANWAFLLPkagrrR 212 Saccharomonospora ...
Feature 1                                            ##  ##  ##  #                            
CAM01397  227 RDLRARLREHLRRaepgslae--tvaraetPVQAPEEQVPHWLFAFDAAGMAAFRALALLAAQpeQAARArseiaesdl- 303 Saccharopolyspora ...
ADB32875  213 LRFQALLDEYVDRaepgslvh--alppgsaQELDAAGQVPHWLFAFDATGIALWRLLALLGSRpeYAEVIaeearnpq-- 288 Kribbella flavida ...
ABK75075  219 SRFLSHLYRYAEDpepgtlvg-aladvpagGAVDPVGQIPQWLFAFDAAGMALLRALAVLATHplQRDRAledagepn-- 295 Mycobacterium smeg...
ACY97998  225 EVCRRRLRGYVERaeadslvg-elsrlpegMPGDPVSQVSRWLAGFEATALVSYRTLALLAAHpgHLARVrgelsvlpgt 303 Thermomonospora cu...
ABC93947  219 QRKLARFHEHVGRylvdpekhslvnrfpkgDKLAPENQVAQWLFAFDAAGTAVIRTLALLACHvsYWGKAveeamgv--- 295 Rhizobium etli CFN 42
ACS60666  240 KRYQKRVAEYLRQpepdsli----srlpnrAEVEPESQVAQWLFAFDAAGIATFRALALLGCQpdEQARAveeadaa--- 312 Rhizobium legumino...
ACU95316  213 DAFRRRLDEHLSRaepgslaaviaerepedDTVDPFGQVPQWLFAFDAAGMVVLRALALLAIHpkQAKVAreeaavd--- 289 Saccharomonospora ...
Feature 1                       #        # #                          #                       
CAM01397  304 --atpqplhhLRACVLDALRLWPTtPMLLRDSVEetawd----grqlPAGTAFLVFAPLFHrdetaadfAHAFTPEAWld 377 Saccharopolyspora ...
ADB32875  289 ---gspllahAGAAVQDCVRLWPTtLVVLREGVVptewn----agtaPAGTEFAIVSSVFHrdgealkfADEFVPEIWld 361 Kribbella flavida ...
ABK75075  296 ---rpllrpyLRGCLLESVRLWPTtPAILRDTTEdthwregaerftvAKGAGLLIVAPAFHrddqvlpfAHDFVPEIWid 372 Mycobacterium smeg...
ACY97998  304 alagpvavpyLRACVLEAARLWPVaRTVLRQSRGetvwh----grtvPAGSVFVIVVPFFNrdrealahADRFAPEVWld 379 Thermomonospora cu...
ABC93947  296 ----dldrpfTRSCLLEVLRLWPTtPAILRQLTKdiqsg----drviARGTGVIIFVPFFHrdpa-lvyADRMEPSIWgr 366 Rhizobium etli CFN 42
ACS60666  313 ----aadrpfARAVLIDAVRLWPTtPAILRELTEdhiig----gqtiRKGTGIIIFAPFFHrnderldiANRMSPTTWfd 384 Rhizobium legumino...
ACU95316  290 ---dpgawpyLRACVLDTVRLWPTtPLVLRESTAatswr----gtrlPPATLFLAFAPYFHraaelvpfADTFTPEAWld 362 Saccharomonospora ...
Feature 1               ###   #####  ##                                                
CAM01397  378 graehhsalVPFSAGpGRCPGENLVLLVTSTLLAVLMRDAEfepgeg----palgpqGPLPATFDnfHTTVRL 446 Saccharopolyspora erythra...
ADB32875  362 gradgewplIPFSAGpAVCPGRNVVLLTTSAAASHVVAHFDldpdpa----trsklaGAMPATFD--HSSPRI 428 Kribbella flavida DSM 17836
ABK75075  373 graqlypqlVPFSAGpAECPGRNLVLFTTSTLAANLLNRLHfdvrse----prpvpgEPLPMTFN--HAGIEF 439 Mycobacterium smegmatis s...
ACY97998  380 gravpdeavVPFGGGaGRCAGENLALLAATTFLAALLRRHEplpirs----prlgegRPVPYGLD--HFATRL 446 Thermomonospora curvata D...
ABC93947  367 ndalpaaglVPFSAGpVICPAHNLVPAIASLAVGTFLSSADivllh------psltvANLPGTLN--HFDIRL 431 Rhizobium etli CFN 42
ACS60666  385 teskpseglVPFSGGaAICPAHNLVPTVASLAMGAILSKATisvve------psldpEQLPGSLD--HFEIEI 449 Rhizobium leguminosarum b...
ACU95316  363 graqdlpglIPFSAGpARCPGENVVLLVASAMLAEFLRAGEyrllaprtlrshdharDRLPTTVN--SFGIRL 433 Saccharomonospora viridis...

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