Conserved Protein Domain Family
CYP5011A1-like

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cd20621: CYP5011A1-like 
cytochrome P450 monooxygenase CYP5011A1 and similar cytochrome P450s
This subfamily is composed of CYPs from unicellular ciliates similar to Tetrahymena thermophila CYP5011A1, whose function is still unknown. It belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410714
Aligned: 30 rows
Threshold Bit Score: 376.21
Created: 18-Aug-2017
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                 #   #      #        
ABY59983   74 PDAKSLAINIgGNIALYLIDPEMIKEFYSlnc--yqKSPFIVKMFSRVLGNGFlf-dEISHNRKRNIFSKLFHFDnlk-- 148 Tetrahymena thermo...
ABY59974   77 QNLDGFVANLgSTPVIYLLDATLIGEFLQkqteyyqKSEFATKMSILLFGKGVvfseGEEWKTKRKLLSNTFHYNliq-- 154 Tetrahymena thermo...
ABY59987   70 PYQKVYVTNIgPYIKLRIFEPEIIRDFFQnqh--nyKKFEFFTGNLMRFVNGIitaeGQDWKSSRKLFSQAFHFDyiqkl 147 Tetrahymena thermo...
ABY59950   73 KNDNDVQFLI-GYNNIHIVDAQLAKDITLnnl-qniRKDMGMQFGDLLFKQGIvfseGEKWKKQRQILSHSFSFDvlk-- 148 Tetrahymena thermo...
ABY59949   75 PKLKAVACSLgFGVLITSVDPDMNKSFLIdny--qkSVKLAPIFNYKILKNGIifseGEQWKKQRKMISDSFHFDsky-- 150 Tetrahymena thermo...
ABY59988   69 NQKKMFVENIgKNIKIKLTSIDMMKDFYSylgdkltIDTFYTQNFKRIFGNGLifsqGERWKNMRKMFSPAFHFEylknl 148 Tetrahymena thermo...
EAR91702   71 SDPKIYVENNaTGAIIKISDPEYIKEFVQlenkayqKTTLLIDNIIRLVGQGIifseGPQWKKNRNVLSGVFHFEqls-- 148 Tetrahymena thermo...
CAK66302   64 KTVKFIVHNYaSAVYILIIDPDYYQFMLNnh---enYSQINDLNTSQLLDEGImfqqGERWKQQRELLIQYFDIDklk-- 138 Paramecium tetraur...
EAR96212   77 KDQDIILSNLnSKASLLIVNPDLISEFLQcqq-hyiKYELPFHSLNKLIGTGLakhyGDGWKKSRKILSNMFTFEqia-- 153 Tetrahymena thermo...
ABY59981   77 KDQDIILSNLaDQALLTLINPELINEFLQrqn-eyiKYQLPVQGIEDFLGNGLsrqyGEKWKNGRKVISNMFTFEnit-- 153 Tetrahymena thermo...
Feature 1                                                #                                    
ABY59983  149 --qvVPKIEQITQNWVIQKCPLvkktvqridmidLSQHISGDIITQQFFGINMNnqrykektipqnlyhlntatcnqmrt 226 Tetrahymena thermo...
ABY59974  155 --dqVKLVLNVTEKIFEQQDQNsvc------flqTVEKIGGDVGLMSFLGADINnytlfg-------------------- 206 Tetrahymena thermo...
ABY59987  148 apliEKSTNTIIDEIIAKNELQnfn------sitCMQELTGRVVIASFFGESLEnerlkgrtivetls------------ 209 Tetrahymena thermo...
ABY59950  149 --nrVSKINNIVKEMINKIQIEegkpt---kivtECTKITAEVVLRSFFGERFSqqqhkginl----------------- 206 Tetrahymena thermo...
ABY59949  151 -yffSQKFNLLTLIMFKKVQNRvsvd-----sqlFFTKIKGEIGIRVFFGPDFGdhqidgkniseel------------- 211 Tetrahymena thermo...
ABY59988  149 sssiEKIVDNALLEHINQDELQnvn------iinLIFDMTSQVVFFSFLGDNLQdikfkgksla---------------- 206 Tetrahymena thermo...
EAR91702  149 --krVPSIEKITKEVYKRYIDSgnvkn--vdvieLFQEITAEVVIQTFFSNISKdksfygmslsva-------------- 210 Tetrahymena thermo...
CAK66302  139 --rnLPKLNEIIKQNFKQYDYQndq------iqtTLLIIISDILIQSFFGQDANkllinnkcigle-------------- 196 Paramecium tetraur...
EAR96212  154 --lqLGSIRELSKRYISQQNEKsfn------iqkVFEMTAGASDLSIFLGFDMDeyknkdgktlgeli------------ 213 Tetrahymena thermo...
ABY59981  154 --aqLQRVKEISRKYINNEDTEkfn------ikyVFEKISGSQNLQVLLGAEVEkykdsegrhlg--------------- 210 Tetrahymena thermo...
Feature 1                                                                                     
ABY59983  227 iryiltgtytfdkgwcrfdrvvNEDIKNIKQILIDALYsrinkqsqq-------qkqsqsqedFQVDTENSIIDQIIKNG 299 Tetrahymena thermo...
ABY59974  207 ----------------qeptagINQYINQLMSYMKNPLtvlmggylfnnqvrgsdkkvkqgsqEIKNLLKKVVLDVIDRT 270 Tetrahymena thermo...
ABY59987  210 ---------yilnalarqtgtlIYLIFGKKFFQLGLTKhsr-------------------einQLIEEFNSFLQNKIASK 261 Tetrahymena thermo...
ABY59950  207 --------------giylaqllLSVFDQTRRLRMLIPSfffpkfmski-----fadekyyevqKNCIEFRQLIEKEVNLR 267 Tetrahymena thermo...
ABY59949  212 ----------keivdqtivysyTSIFFQLKRIFLGDELamkflta------------kekkllSRSDRINQIAMEQIEKK 269 Tetrahymena thermo...
ABY59988  207 ------------qaithilsalSNQVMELGYLVFGAKYlklgifk------------qhreleNYLQEFKSFFLDIIKSK 262 Tetrahymena thermo...
EAR91702  211 ----------lsylinsvgkqiSTPFYFLFRTNFFKWGiresd----------------rklnKQIKEFRQMIGDIINER 264 Tetrahymena thermo...
CAK66302  197 ----------ttdlfealsklsRKPYSICKNILFGVQAlkmfpss------------eeqiiqTKINNIKFTIEKIIQKR 254 Paramecium tetraur...
EAR96212  214 --------gsfandvylrdvgmFSMIFGTKATELGLRKsdk-------------------dlnERGKNLRKFMYEIILEC 266 Tetrahymena thermo...
ABY59981  211 ------------ecvqqlsndiCALYISPFAMIFGQKIlkwnlre------------adrqiqKRMKDMRELMTKILIDC 266 Tetrahymena thermo...
Feature 1                                                       ##  ##  ##  #                 
ABY59983  300 YILDKkssdmskqek----------------eeltksnkilPEELLEEYLTFYLAGMETTGHTVGFCFYFYCKYphIGEK 363 Tetrahymena thermo...
ABY59974  271 KNQMNdgkqnvdtsiisl-----------mlkngqlkteeeIDELVILTLNFYFAAKDTVSRLVANLMYYIGKNdhIYNK 339 Tetrahymena thermo...
ABY59987  262 IEEIQndikqngntsnfsi--------laqlvstsqidqisRQQLFEDFKAFYLAGMDTTGHLLGMTMYYLTQYkdVYSK 333 Tetrahymena thermo...
ABY59950  268 IENYDqnktqkdfldilvdey----klnyskndgkveeyitKESIIHQFIVFFFAGMDTTGNLTGIMLYWVSKRkdIYEK 343 Tetrahymena thermo...
ABY59949  270 IKYYEgqpsvqsdylidvl---------vrnyltkqdpnltKEQICQQCITMFIAALDNTGCIIAWIIFCLANYkeEGDK 340 Tetrahymena thermo...
ABY59988  263 KEELQkefqetgdiqqncv--------lsilikenniqnlsDSDLLDNLMTFFIGGTDTTSHLIAMAIYYVCQNehFYSM 334 Tetrahymena thermo...
EAR91702  265 IKEEEelekrgeqttkedl--------vyylkknnllgvlsLDEIISEFMTFYVAGMDTTGHLCGMAIWFLTQHpeIKKK 336 Tetrahymena thermo...
CAK66302  255 IVQHElkldedeneisqmsedilniyiqaylqtkkgnnrmsFEEIKQQYFTIFKIGSQTTNQIIQASLHYLAEQpqIQNE 334 Paramecium tetraur...
EAR96212  267 KKREQqpgyqpkypsfih----------hlvqenllnteeeLEDLLAISFNLFLAAKETTSKIAANVVYYAIKYpeQYKK 336 Tetrahymena thermo...
ABY59981  267 VNHEKdpsyeakfpsyit----------fllragylqtdeeINDLRATAFSIFLGAKESTSKLANMTIYNLIKHpeQYKL 336 Tetrahymena thermo...
Feature 1                                         #         # #                       #       
ABY59983  364 LRKEInqhfshd---qpityekISQLNYLDCFIKEIFRFYGPtsTLMYRIATQDhk-iKDIEIKKGSMVNLAILTNFYns 439 Tetrahymena thermo...
ABY59974  340 LEKEIlsfkde-----einienMKKYNYLEAVIKESLRVCGPspFLIQRTALQDhn-lGKYKIQKGTDVNCVFIYNFYne 413 Tetrahymena thermo...
ABY59987  334 LQQEIdtnqd-------qsiqcISQLPYLNAVIKESLRYYGPanILFDRIATSDhv-iGGIPIKKGMIITPFAISMHRnq 405 Tetrahymena thermo...
ABY59950  344 LVQEIksvfgqnk-dpeindeqLKKLNYCHMFIQECLRYHCPamLLFTRRAERDfyigDNILVQKGMQVNISLHGVLRre 422 Tetrahymena thermo...
ABY59949  341 VRQEInsvfptqetldniqfddLKNLNYTSAFIDECFRHYTSsmGVFLRRVVEPfk-sGNFEIQKGDIIQSLWHPTQFnp 419 Tetrahymena thermo...
ABY59988  335 TQKEVdyykq-------dksksMQDLPFMNAVIKETLRIYGPgnKSFDQKVTEDim-iNNIKIEKDIVLTSYVNSVHRdp 406 Tetrahymena thermo...
EAR91702  337 LQEELdantd-------ysqngLLKLPYLNGVIQETQRLYGPagQLFNRVALRDhm-lKDIPIKKGTIVKPSPCSVHRhp 408 Tetrahymena thermo...
CAK66302  335 LRQEIlsicktd----iisyqeLKSLVKLSAFLNEVLRFVNP--IPIVRKVQTThf-iKDLKLKRNWVVMVDNSVTNSse 407 Paramecium tetraur...
EAR96212  337 IQEEIktyvpnd----dytfadLQKMNILQANVKECLRYDTSgpFLFQREVVQDht-lGKYNIKKGTLVNCGYVVNFFne 411 Tetrahymena thermo...
ABY59981  337 VYDEIqkyvshd----dynyldIQKLNHLQANIKETQRTDPSsaFLRLRVAQNDht-lGKYQIKKGSIINVGYLANFYne 411 Tetrahymena thermo...
Feature 1                                    ###   #####  ##                                  
ABY59983  440 kifKNPEEFNPDRWLeknq-----insyAYLPFSAGrRNCIGQHLGLLTIKIVFSVILRDFEvt--lTNPDYQMDRl--q 510 Tetrahymena thermo...
ABY59974  414 kyfENPFEFNPERWLdqaqlekikinpfSYLPFSGGsRNCIGQYFAMMEIKAIMIYFMRTYEkfqipENFQYHIIIktti 493 Tetrahymena thermo...
ABY59987  406 nifENPHAYNPSRWLdkkis---einsfSYIPFSSGqRNCIGQHLAQMQTKIILNKFIKKFNfs-cpENYKLVMAFkfls 481 Tetrahymena thermo...
ABY59950  423 kyfQNPDEFIPERFSeenkk---ninhlAFIPFSSGpKNCIGQHMALIEAKIILVQFILNFDit-nnENVPLKMDSnsly 498 Tetrahymena thermo...
ABY59949  420 dwfENPDKFDVNRFLngkek---qgnsyAFTPFSIGpRNCIGKQMSLVEVKVSLIYFVKKFNci--rNSVPLKTTAsivy 494 Tetrahymena thermo...
ABY59988  407 qiyKDPHTFRPQRWInqetn---dlpsyAFIPFSSGkKNCIGQHLAMIEARIILFKFFDYFDie-pqKDYVLKIKYgllp 482 Tetrahymena thermo...
EAR91702  409 kyfEDPHSFKPERWFnknt-----vtpyTFIPFNAGpRNCIGQHLALIEARIMINYFMKTFDfe-sdPNFEMVLNYafli 482 Tetrahymena thermo...
CAK66302  408 kyyDNPKEFNYQRWLqsesik--ennnyVFIPFSNGpRNCVGQSLATMIYQIILINILRNFEv---nVNEKSKNNKs--i 480 Paramecium tetraur...
EAR96212  412 kyfENPFSYQPERWLdsnndskmknshlVYIPFSGGaRNCIGQHLAVMQIKAMAIEFFKQFKlpeipKDFDTEKIMtlsy 491 Tetrahymena thermo...
ABY59981  412 kyfRDPFTYNPSRWFdkqedlkikenhfVFIPFSAGsRNCIGQHLATMQIKVMIVEFIKKFHlpqipPDFDDEKTMiqsy 491 Tetrahymena thermo...
Feature 1               
ABY59983  511 KFVHGPSSPI 520 Tetrahymena thermophila
ABY59974  494 ETKDHLTCSL 503 Tetrahymena thermophila
ABY59987  482 EPVDPLCLKL 491 Tetrahymena thermophila
ABY59950  499 CPVNDELLFL 508 Tetrahymena thermophila
ABY59949  495 KPVDQNLIKI 504 Tetrahymena thermophila
ABY59988  483 QPVNPLLFNL 492 Tetrahymena thermophila
EAR91702  483 EPVDKLRINL 492 Tetrahymena thermophila SB210
CAK66302  481 TFVLQNSSFK 490 Paramecium tetraurelia
EAR96212  492 GFKNDLLLNL 501 Tetrahymena thermophila SB210
ABY59981  492 GFKNPLIVKL 501 Tetrahymena thermophila

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