Conserved Protein Domain Family
CYP132-like
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cd20620: CYP132-like 
cytochrome P450 family 132 and similar cytochrome P450s
This subfamily is composed of Mycobacterium tuberculosis cytochrome P450 132 (CYP132) and similar proteins. The function of CYP132 is as yet unknown. CYP132 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Links
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Statistics
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PSSM-Id: 410713
Aligned: 50 rows
Threshold Bit Score: 450.107
Created: 18-Aug-2017
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                  #   #      #        
P59954      44 SDITRFRca-grRFVSISHPDYVDHVLHEArlkyvksd--eygpiratAGLNLLTDEGDSWARHRGALNSTFArrhlrgl 120  Mycobacterium tu...
CAN95048    40 GDVVRLRapgaeDFVMAFHPNDIAHVLRTNarnypkgk--ryhelapvLGWGLVNSEGELWRRQRRHVQPQFNhantlkf 117  Sorangium cellul...
ABX04867    40 GDLAHLQlg-skDMFLVVHPDHVRRVMVEQrdtyskkas-yegvrkllLGDGLVASTGSLWRRQRKLMAPFFTpraiety 117  Herpetosiphon au...
ACY15519    47 GQITVLKag-ptQVYLITHPDHVKHVLQHSergfskgp--mwdplrrvFGDGIGTSEGSEWLRSRRMAQPLFStknidsl 123  Haliangium ochra...
CAN92350    25 GELIELDlg-ltRAYLATHPEQVQYVLHDNwrnfgkegg-mwkpigrlLGNGLVTAGGDEWLRNRRRMQPLFSsrqlagl 102  Sorangium cellul...
ABV97189    27 GDVVRVSlg-vsRPYLVTNPAHVQEVLHERaaiyprgddtalwrsvrkLVGDGILAEGDAWAASRRVLAPMFRparinam 105  Salinispora aren...
ACF05266    48 GEVARLRlg-pyTVHLVTEPDAVSRVLKENsanyvrgt--lyeqfrtvMGNGLLTTDGDDWKAHRRAVQPVFLrkavaai 124  Streptomyces peu...
YP_112329   38 GDVARNRlg-pfVTHALAHPDHIQYVLQENhrnyvrgr--fydnfkmfFGDGLLTTDGEFWRRHRRVVQPLFHkkqvdah 114  Burkholderia pse...
AAL06697    35 GDAVRVSmg-pkKLYIFNRPDYAKHVLADNsdnyhkgi--glvqsrrvLGDGLLTSDGETWREQRRIVQPAFKpgrinqq 111  Streptomyces glo...
ACY99338    46 GAIARIDlg-lfRPYLITDPAHVQHVLRDRadnyqrgv--vmwkpvsrLVGNGISSEGPLWRSSRQVLARVFSaqyishf 122  Thermomonospora ...

Feature 1                                            #                                         
P59954     121 VGLMIDPIADVTAALVPGAQf----DMHQSMVETTLRVVANALFsqd-fgpLVQSMHDLATRGLRRAEKlerlglwglmp 195  Mycobacterium tu...
CAN95048   118 VPIIVEHMEAVLRRWDAQPGef-erDINDDMMDVTFGIAGEAFFgaa-lhaHTDTVREAFKYALSIALKrmyslvnpp-- 193  Sorangium cellul...
ABX04867   118 LPIIVEDGAWFRERWSAAAKqgeplDILTEMSVLTASIILKSMFsle-addTIAWVKHAVETMIGFASSrqmnplhap-- 194  Herpetosiphon au...
ACY15519   124 VGSMSEIVARHVARLAPLVGsgesvDMNVEMMRMVQDVLVATLFgvdvpaqQMTTIADAIQRILSSSQLelllgmvlp-- 201  Haliangium ochra...
CAN92350   103 VDRMFDVVEGDLPRLEERARagavvDMDKEMMQLTQRVILATMFgvsitprEADSLGEVLLVAIQALNArmflyfmp--- 179  Sorangium cellul...
ABV97189   106 VDTMADAIAGAIDDLHGAATagtpiDVGRELSRIVCSAIMRVFFadritvrDALRIMKAQETIVTAMAPrilaplvpw-- 183  Salinispora aren...
ACF05266   125 EPNVVRATNEMLDEWEVKACrgepvDLVTETLRLTLVTLSRSLFgyd-irpATPVLKDVVNNVIEVMFKhgsvaem---- 199  Streptomyces peu...
YP_112329  115 TAAVGDAALALAHRWSALPPgk-alDVVEEMMHLSLRMLGLMVFntd-vssHAEAVGPAVRFGIEAMMPqgnlndfip-- 190  Burkholderia pse...
AAL06697   112 AAAVAEEAAKLVALLRGHEGgg-pvDVLQEVTGLTLGVLGRTLLdsn--ltAHESLAHSFEEVQDQAMLemvsqgtvp-- 186  Streptomyces glo...
ACY99338   123 TERMAEAINAAADDLLARAAdq-pvDVRREMNRLMHRAISLVFFddrlsvaEIDRLGAAVSAASSSFMWrmampfvpn-- 199  Thermomonospora ...

Feature 1                                                                                      
P59954     196 rtvydtliwciysgvhlppplrEMQEITLTLDRAINSVIDRRLAeptnsadllnv--------llsadggiwpRQRVRDE 267  Mycobacterium tu...
CAN95048   194 -------------lswplpshlRFRRAMDRVHAVIDGIIDGYQRgaggednvlvrlm----nsvdpetgakmdRAQLRDE 256  Sorangium cellul...
ABX04867   195 -------------lwmptpknrAYLEARNRVNQYIQGIIAERQRqapdewpndlltrm--mqardeetgepmsTVLLRDE 259  Herpetosiphon au...
ACY15519   202 -------------hrllqpmdlLVRRPRQVLDEVIFDLIAQARAsdsdsanflswfl----rardidtgkgldDQQLRNE 264  Haliangium ochra...
CAN92350   180 --------------drllpgerALRDAIARIDEAILRLVRERRRskeerddllsll-----lrardesgsgmdDRQLRDE 240  Sorangium cellul...
ABV97189   184 --------------wipmpgdrRFRAAVRSIDDILLPVLRQAQRqpddgddllsrl-----vharaddgralsEKRMRDD 244  Salinispora aren...
ACF05266   200 ---------------lpswlptRRNRLISRDRRIFTRLVTEIRDnhaatgegplmeli--eaatdpvtgarwsDEEIRDE 262  Streptomyces peu...
YP_112329  191 -------------rwaptrfnrRIAHARRAIDTIVAKIIADHREarcepsdvislll----nardpdtgapmtQQEVHDE 253  Burkholderia pse...
AAL06697   187 -------------awlplppqaRFRRARRELYRVADLLVADRRSrmadggpgddalsriivaadrrrddparaRNRLREE 253  Streptomyces glo...
ACY99338   200 --------------avpmpgdrTFRRATRTVDEILRPLVAEGRKrppgghdvvskl-----ieareedgtpfsDQRIRDD 260  Thermomonospora ...

Feature 1        ##  ##  ##  #                                                 #        # #    
P59954     268 ALTFMLAGHETTANAMSWFWYLMALNPqARDHMLTELddvlgmrrptadDLGKLAWTTACLQESQRYFSSvWIIAREAVD 347  Mycobacterium tu...
CAN95048   257 IKTILMVGHETSSVTASWALYQLARHPeVCARLTDEIdrvlggrsptarDIESMPYLTMVFNECLRLLPSvPFILRSPLE 336  Sorangium cellul...
ABX04867   260 AITVFFAGHETTARTLSFLWYALANNPdVAERMQAEIdsvlgdaaptldHLKQLPYTLQVIKETLRLYPAaPMYARDAVA 339  Herpetosiphon au...
ACY15519   265 LISIYVAGLETTMCSLLWLWYHLDQNPeIDGKMRAEVdavmgassitaaKLEQLSYTKMVIQESMRRLPTiWMMPRYSRE 344  Haliangium ochra...
CAN92350   241 LVTMFIAGNETTAITMTWLFYLLDRNPgIERKLRAEIeevvgdrrptaaDLSRMEYTKMVIQEAMRMYPPsWLVPRTVKE 320  Sorangium cellul...
ABV97189   245 LVSMVAVTTETSTVVLTWLWPLLANHPdVANRLYDEIdrvvgggpvrgdHLAELTYTRMVLDELLRLYPAgWILPRRAAT 324  Salinispora aren...
ACF05266   263 MLTIYLAGHETTAVALLWTLVSIANHPgVADEMDEELarelgratptaqDVERLSYTNQVVDESLRMYPPiWIYPRDAVA 342  Streptomyces peu...
YP_112329  254 VMTVFLAGHETTGAGLAWALYALAQHPaVLRQLRDELdarlggraptvqDFEQLPYLSQVVDEVLRVYPPiWGFTRDLVE 333  Burkholderia pse...
AAL06697   254 LVTLLLAGHETTASTLGWTLHLLERHPeVRDRVRAEAraalgdgvpgpeDLHRLTYTTMVVQEAMRLFPPvWILPRVAQQ 333  Streptomyces glo...
ACY99338   261 VVALFVSGTESTADGLTWLWVALHRYPeIAERVYAEIrsevgdgparpeHIRRLPYTQMFLQEVLRMHAVgWAVPRVAVD 340  Thermomonospora ...

Feature 1                        #                                        ###   #####  ##      
P59954     348 DDIIdgHRIRRGTTVVIPIHHIHhd-prWWPDPDRFDPGRFlrcpt-----drprCAYLPFGGGrRICIGQSFALMEMVL 421  Mycobacterium tu...
CAN95048   337 DDVIggYKVAAGSTVAIVPWVTHrh-peFWSDPLEFKPERFanhrr----saddkLAFIPFGAGqRICLGEFMGQLEGKI 411  Sorangium cellul...
ABX04867   340 SDEFagIKVPVGSRMTIMPYLTHrh-pdFWDKPLRFDPDRWlpere----alrhpFAYHPFAAGqRICIGNNFSLFESHV 414  Herpetosiphon au...
ACY15519   345 DNVIdgYKIPADSLIFLSPYATHrd-pkFWERPEAFYPEHFtperv----aarprYAYYPFGGGpHQCIGKYLAMTDQLL 419  Haliangium ochra...
CAN92350   321 DDQIcgYPVPAGATVILSQYVMHhd-paFWEAPAEFDPERFtpers----asrprYSYMPFGGGpRQCIGNLFSIMEAQI 395  Sorangium cellul...
ABV97189   325 TDILggVRINKGATVILSPYVTQrmtawWGPTAEAFDPERFaagrea--adgrhrYAYYPFGVGmHRCLGEHLFNLEAIL 402  Salinispora aren...
ACF05266   343 DDELagFHIPAKSSVLLSPLASHrn-prYWKNPQAFDPHRFdpdrv----kerprMAYFPFGAGaRMCIGNFMALLELRM 417  Streptomyces peu...
YP_112329  334 DDEIggYRIPARSSVFMSPYVTHrh-paFWRNPDAFDPENFasdap-----arhrFVYFPFGGGmRKCIGFQTALLQMRV 407  Burkholderia pse...
AAL06697   334 RDVVggYTVSAGSDVLVCPYIMHrh-pgLWEDPERFDPERFeprqt----adrprYAYIPFGAGpRFCVGSNLGMMEAVF 408  Streptomyces glo...
ACY99338   341 DDVIagVPIKKGATVVLSPYLTHrd-rrIWERPEEFDPERFtperikariqrhgrFAYFPFGGGdHVCLGEQLFKIETTL 419  Thermomonospora ...

Feature 1                                                   
P59954     422 MAAIMSQHFTfd----lAPGYHVELEat------lTLRPKHGVHV 456  Mycobacterium tuberculosis variant bovis AF2122/97
CAN95048   412 MVAMALQRYRlr----lVPGFDPRCRgf------iSLQPVNGMRM 446  Sorangium cellulosum 'So ce 56'
ABX04867   415 VVAMLARHFAlr----tVPNHTPQVWmd------gTLGSRNGLPM 449  Herpetosiphon aurantiacus ATCC 23779
ACY15519   420 IVAMMVQRFRpr----lLLGSTVDPRps------lFLRPRHAMRM 454  Haliangium ochraceum DSM 14365
CAN92350   396 VIAVLLRRLRmr----lVPGHPVSPQav------aTLRPRHGLKM 430  Sorangium cellulosum 'So ce 56'
ABV97189   403 IVATLLSRFRfaltdtsMPGVKVAAStrpartvevILKPVAPVPA 447  Salinispora arenicola CNS-205
ACF05266   418 IVAMIHQRFRls----lVPGDSLRYGdt-----aiSLRPLSKVLV 453  Streptomyces peucetius ATCC 27952
YP_112329  408 LVAVVAQHFDln----aLPGHPIELGat------iSLRPVHGIRL 442  Burkholderia pseudomallei K96243
AAL06697   409 VTALVTRDLDlr----tVAGHRAVAEpm------lSLRMRGGLPM 443  Streptomyces globisporus
ACY99338   420 IMASLLSRARpv----lRNDGPIESQlt------lTVRPSRPVQM 454  Thermomonospora curvata DSM 43183

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