3RUK,2HI4,1R9O


Conserved Protein Domain Family
CYP1_2-like

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cd20617: CYP1_2-like 
Click on image for an interactive view with Cn3D
cytochrome P450 families 1 and 2, and similar cytochrome P450s
This model includes cytochrome P450 families 1 (CYP1) and 2 (CYP2), CYP17A1, and CYP21 in vertebrates, as well as insect and crustacean CYPs similar to CYP15A1 and CYP306A1. CYP1 and CYP2 enzymes are involved in the metabolism of endogenous and exogenous compounds such as hormones, xenobiotics, and drugs. CYP17A1 catalyzes the conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products, while CYP21 catalyzes the 21-hydroxylation of steroids such as progesterone and 17-alpha-hydroxyprogesterone (17-alpha-OH-progesterone) to form 11-deoxycorticosterone and 11-deoxycortisol, respectively. Members of this group belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410710
Aligned: 79 rows
Threshold Bit Score: 308.373
Created: 15-Aug-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                             #                          #   #        
3RUK_A     43 GPIYSVRmgtkTTVIVGhHQLAKEVLIKKgk-----dfSGRPQMatldiasnnr--kgiafadsgaHWQLHRRLAMATFa 115 human
1R9O_A     45 GPVFTLYfglkPIVVLHgYEAVKEALIDLge-----efSGRGIFplaeranrg----fgivfsngkKWKEIRRFSLMTLr 115 human
T16867    155 GPIFTLHls-qPTIILAeYKTIQEALVKNgq-----qtSGRSSAesfvlftgdrlngdgvilamrqKWKDMRHEISRFMn 228 nematode
T15318     88 GGIFTVWigpiPLVMVSdLPTIKKYFIQHad-----sfSNRWRNfvtdsimegs---ngivqidgnKWREQRRFALHTLr 159 nematode
NP_507076  57 GPVFTFWladrPFIFITsYEVMKETFVKDgd-----tfADKQLNqidkkklqrn---ygvldtngeMWREHRRFTLSQLr 128 nematode
NP_503616  59 GGVYTFWmgniPYVIIGsYDLLKETFVRDgdty--kdkYPQPFNeklrggmy------givesnghMWSTHRRFALSTLr 130 nematode
P90771     60 GGIFTLWlp-fPTIVICdYDMLKRNIVKNge-----sfSGRPDTfimdmlvqgn---yglffmennWWKAQRRFTTHIFr 130 Caenorhabditis ele...
NP_503594  59 GDIYTFWigntPHIMINtWDKIKETYIRDae-----tyTNKVRLpaldlfrgge---ygiidsngaTWREHRRFALSTMr 130 Caenorhabditis ele...
NP_504988  59 GKIYTVWmgtdPAVIITgYKELKDTFVNDghsyldkmiYSKLNTslrggdyg-------vidtngnTWKEHRKFALHTLr 131 Caenorhabditis ele...
NP_503303  59 GDVFTFWlgdtPYVVISsLEKMKETFIKDge-----tyQDKIQFsftekfrggr---fgviettghMWSTHRRFAISTFr 130 Caenorhabditis ele...
Feature 1                                                                                     
3RUK_A    116 lfkdgdqklEKIICQEISTLCDMLAthng---qsidISFPVFVAVTNVISLICFNtsyk----ngdPELNVIQNYNEGII 188 human
1R9O_A    116 nfgmgkrsiEDRVQEEARCLVEELRktka---spcdPTFILGCAPCNVICSIIFHkrfd----ykdQQFLNLMEKLNENI 188 human
T16867    229 kwy--gapmDELVLHHTRCLEQELAkiaet-kslidLRDPLAGAIANVIQQITIGrnym----yqdQEFQTQLRDINAVV 301 nematode
T15318    160 dfgvgkplmEQMITLEVTSLMNHMEkscgldgkelhLCPSIAVCVGNIINNMLFGlrfn----qdnSYMHRLHQLLDDQS 235 nematode
NP_507076 129 dlglgkdlmQEKILLEIEEQFKDINshlg---eeidLPSVLDRGVGNVINLTLFNkrfe---tnqrDEFTYLKSLIDGLR 202 nematode
NP_503616 131 dfglgkdlmQEKILIEVEDIFRKYDaqlg---keqdIQVVLNNAIANVINQTIFGyrfdetnqeefERMRHLVEYQEKQF 207 nematode
P90771    131 slgvgqagtQDTIASLASGLVEKIDgqkd---kpieLRPLLVHVVGNVIHKHLFGftre----wneTEILDFHVAINDVL 203 Caenorhabditis ele...
NP_503594 131 dfglgknlmQENILMEVQDVFARLDaklg---setdIPEVFDHAVANVVNQLLFGyrfv---gpkeSEYQELKRIIEAPT 204 Caenorhabditis ele...
NP_504988 132 dfgmgkeamEASIQLEVDKIDEELKkveg---kevnIQEHFDLAIGNIINQFLFGnrf-----kdsSKFNELKKLLDLFF 203 Caenorhabditis ele...
NP_503303 131 dlglgknlmQEKILAEVEAVFQILDanlg---aeqdVPEVIYNAVANVINQMIFGyrfdesnqnefEKLKDLIDIQEKSF 207 Caenorhabditis ele...
Feature 1                                                                                     
3RUK_A    189 DNLSkdslvdlvp-----wlkifpnktLEKLKSHVKIRNDLLNKILENYkekfrsdsitnmldtlmqakmnsdngnagpd 263 human
1R9O_A    189 KILSspwiqicnnf---spiidyfpgtHNKLLKNVAFMKSYILEKVKEHqesmdmnnpqdfidcf------lmkmekekh 259 human
T16867    302 KEIMtaevffvncypwlrylpegilrkWTNYKRSGFRLQQWFRTILEEHhvnrhqgdfmshm-------------idlqe 368 nematode
T15318    236 HTVMqpimgayiafp-vtskipiingeWNRLMGIKNELLEFLETQIEGHrmnwkdemieqepedltyaymievekrkrng 314 nematode
NP_507076 203 DVASefryfiqflvp-wsskiipgptlGDKTKGMKEELDVFFVKQVEEHrkeidfdtvesydyveay---lkeqkkread 278 nematode
NP_503616 208 ATVKvyveafvpti----gkflpgkslDQLLDDWRNSFYTFFDTQIENHrkkidfdseesqdyaeay---lkeqkkqeal 280 nematode
P90771    204 EHFTspktqlldawpwlayldkplslgIPRTTRANDAIIQNLEQALAKHktginydeepssymdafl---kemkiraaen 280 Caenorhabditis ele...
NP_503594 205 DLFGkphmflamnip-viaklmpefmyEGPFKDFRDTAFAFFNKQIEAHrqevdlndlnsestdfvet-flkeqkrrese 282 Caenorhabditis ele...
NP_504988 204 EVQGslrvyfaytvd--flpqwmvellTPDVSRVRDGIYQFFDEQIEEHrqeidfetsdskdyvetf---mkeqkkreae 278 Caenorhabditis ele...
NP_503303 208 ASFKlcvqafvpim----nkllpgkslEDLIAEKRHDYYNFFYAQIQDHrakinyqaeeyldyaeay--lkeqknqeqgg 281 Caenorhabditis ele...
Feature 1                      #  ##  ##  #                                                  #
3RUK_A    264 qdsellsDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNpqVKKKLYEEIDQnvgfsrtptisdrnrlLLLEATIREVL 343 human
1R9O_A    260 nqpseftIESLENTAVDLFGAGTETTSTTLRYALLLLLKHpeVTAKVQEEIERvigrnrspcmqdrshmPYTDAVVHEVQ 339 human
T16867    369 skqeqfrDLSIILTCGDMWTGGMETTVTTLRWGIIYLLNNpeVQAKCQMEILDvfgndipd-mgkmnqtPYVRATLSEIQ 447 nematode
T15318    315 edvgffdDQQLKMLLLDLFFAGMETTVTTLKWAFLLMAKNqkVQKNVQAELDSigqpmie--iqhrtrlPYVQATINEIQ 392 nematode
NP_507076 279 gdhetfcNKQLYAMCFDLWMAGLQTTTVTLTWGFSFYLHNadVQLKIREELDRvigndrlittadknclPYLTAFINETQ 358 nematode
NP_503616 281 gefelfsNTQFSNTCLDLWLAGVSTTNTTVNWTICYVLNHpdVLQKMNEEFDQvvgsdrlvtmgdknnlPYFNAVLNESQ 360 nematode
P90771    281 aledgftEKQLIVAIYDLYSAGMETIIIVLRFAFLYLVNNpeTQKRIHEELDRnvgrerqvvmddqkhlPYTCAFLQEVY 360 Caenorhabditis ele...
NP_503594 283 gdsetfsNVQLSNVCMDLWFAGLNTTTNTITWAISYILHHpeVQDKVHEEMDKvigsdrlittadkndlPYFNAFINEAQ 362 Caenorhabditis ele...
NP_504988 279 gdfasfsNEQLKNMCFDMWVAGMHTTTNTMGFLTAFALNNmdAQRKMQKELTEvigdrvvt-mkdklnlPYTNAFINEAQ 357 Caenorhabditis ele...
NP_503303 282 lgsdlfsDQQLANMCFDLWFAGLTTTNTTINWTISYVLNHpeVQDKMQEELDKvvgsdrlvtisdksslPYMNAVINESQ 361 Caenorhabditis ele...
Feature 1         #   ## #                       #                                     ###   #
3RUK_A    344 RLRPVapMLIPHKANVDSSIg-eFAVDKGTEVIINLWALHhnekewhqPDQFMPERFlnpagtqlispsvsyLPFGAGpR 422 human
1R9O_A    340 RYIDLlpTSLPHAVTCDIKFr-nYLIPKGTTILISLTSVLhdnkefpnPEMFDPHHFldeggnf--kkskyfMPFSAGkR 416 human
T16867    448 RLANVlpWAIPHKTIEECNIg-gYDIPVNTEIIPALGAVLfdpnvfesPKQFKPERFldeegky--rvmeefRPFGLGpR 524 nematode
T15318    393 RIANIlpINLLRTVAEDIEId-gYNFKKGDLIIPQISILMndpeifenPEEFNPSRFldednnv--kkidefLPFSIGrR 469 nematode
NP_507076 359 RCANIipFNLLHVATRDTVIe-gYPVKKGTGVIAQIGTVMsdeqifpdAHCFNPGRFiengkl---kkvdevIPFSIGkR 434 nematode
NP_503616 361 RCANIvpINLFHATTKDTVIn-gYPVKKGTGVIAQISTVMldekifpePYKFNPDRFidengkp--ikieqlIPFSIGkR 437 nematode
P90771    361 RLGYVlpVNFLRCTLTDVEDcegYRLNAGTRVIAQFQSVHvdkkhfpdPEHFNPDRFlnsrgey--irddrvNPFSMGkR 438 Caenorhabditis ele...
NP_503594 363 RGINIvpLNLQHATTRDTVIn-gFKIPKGTGVVAQISTVMnneevfpdPHTFNPDRFidehgkl--krveelAPFSVGkR 439 Caenorhabditis ele...
NP_504988 358 RCANLvpMNLPHAVTRDVQLl-gCTIPKGTTVIHQISSVMsdpeifeePERFVPERYldesgnl--kkieelVPFSIGkR 434 Caenorhabditis ele...
NP_503303 362 RCVNLlpCNLFHATTRDTVIn-gNIIPKGTGVIAQISTVMldekifpdPYKFQPERFidengal--kkieqlIPFSVGkR 438 Caenorhabditis ele...
Feature 1     ####  ##   #                                                
3RUK_A    423 SCIGEILARQELFLIMAWLLQRFDlevp--------ddgQLPSLEGipk-vvFLIDSFKV 473 human
1R9O_A    417 ICVGEALAGMELFLFLTSILQNFNlksl--------vdpKNLDTTPvvngfaSVPPFYQL 468 human
T16867    525 VCLGERIARTELYLIFASLLQNFRfyln--------rgdPIPVAERviggitAPPKPYAT 576 nematode
T15318    470 QCLGESLARAELYLVFANLIQNFNfevaddvttevclklGNPNFSTr----iFKFKIFYS 525 nematode
NP_507076 435 QCLGEGLARMELFLFFANIFNRYDvqld--------fsgNLPDLDKskd-nfVTPRKFNA 485 nematode
NP_503616 438 QCPGEGLARMEIFLFLANFFNRYKisp---------sskVFPNLDKkdn-vgVFPKDLHA 487 nematode
P90771    439 SCLGENLARMEVFLYFCTLMQNFEwhtd--------gpyAPPIDVIts--slRAPKPFTV 488 Caenorhabditis elegans
NP_503594 440 SCPGEGLARMELFLFIANFLNRYKiyp---------skeGPPSMDKsng-alIAPRLFSA 489 Caenorhabditis elegans
NP_504988 435 VCLGEGLARMELFLFTANSFNRYEfnc---------gsnGVPSLERtfa-fiAKAQDYTC 484 Caenorhabditis elegans
NP_503303 439 QCLGEGLARMELFLIVANLFNRYFitp---------ssaGPPSLERtem-vgVFPRKFQA 488 Caenorhabditis elegans

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