Conserved Protein Domain Family
CYCLIN_AtRBR_like
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cd20601: CYCLIN_AtRBR_like 
cyclin box found in Arabidopsis thaliana retinoblastoma-related protein 1 (AtRBR1) and similar proteins
AtRBR1 is a key regulator of entry into cell division. It acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. AtRBR1 plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate maintenance during organogenesis and gametogenesis. AtRBR1 contains one cyclin box. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410304
Aligned: 7 rows
Threshold Bit Score: 219.568
Created: 10-Jul-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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LxCxE peptide
Feature 1:LxCxE peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of human RB (1GUX) and RBL1 (4YOZ) with bound HPV E7 peptide, defined at 4A contacts
  • Comment:The HPV E7 peptide contains the LxCxE motif, shared by other Rb-binding viral and cellular proteins.
  • Citation:PMID 9495340
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                       #   ##        #
Q9LKZ3     730 INIFFTKINKLAAVRINGMVERLQl----sQQIRESVYCFFQHVLaQRTSLLFSRHIDQIILCCFYGVAKISqm---sLT 802  thale cress
EFJ14780   696 MNVFFQKVLKLAASRIKVLCERLSq----pSHVVEQIFQVFEYAL-NRTTIFFNRHIDQIILCSMYGVCKVMkl---nVT 767  Selaginella moel...
AFB17948   126 IYVFCQKVLKLAAIRIKCLSDRLQq----pNLAMEQVYRLLNLVLrEQTGIFFNRHIDQVILCSFYGIAKIQqm---nLT 198  Scots pine
BAN18552   815 LFEFLRKVLKLTSFRLALLCENFDfsplegPEVNSKVYEAIEHALyKQTHLFYNRHIDQIMLSTLYGYCKVHkl--sqVS 892  Chlamydomonas re...
OUS45688   735 LQIFFAKVMQLAARRLGDLASRLKl----sPEVTRDVYALIEHVIyEQTNLVYNRHVDQIILASVYGVCKVNggcggaVQ 810  Ostreococcus tauri
PRW05749   613 VAELLRRVLKLCAIRLADLLSRLDcrpadpQLLLAEAYTLAQHVCfEQSWLLYGRHLDQALLCCLYSICKVHhl--gqAS 690  Chlorella soroki...
PNR34109    27 INVFFQKVLKLAAVRIRNLCERLQq----sQQVVERVNRALHHALnHETGLFFNRHIDQIILCCVYGICKVSkv---nVT 99   Physcomitrella p...

Feature 1      ##                                         #  ##            
Q9LKZ3     803 FREIIYNYRKQPQCKPLVFRSVYVdalqcrrq-grigpdhVDIITFYNEIFIPAVKPLLV 861  thale cress
EFJ14780   768 FRDIIFQYRKQPQSRNHVFRNVYLeqrrg-------rtdmGDIIKFYNEIYVPATKAFLM 820  Selaginella moellendorffii
AFB17948   199 FREIINNYRKQPQCKPQVFRNVFVesrryg----klghetVDIIAFYNRVFIPAVKPLLV 254  Scots pine
BAN18552   893 FREIIAQYRKQPQAQQSIFRSVVIdqvlpt----lqiqsrADIIGFYNAVFVPAMRNFLL 948  Chlamydomonas reinhardtii
OUS45688   811 FKDIIYQYSKQPQCTEEIFWTVVIeqtdpe----levstrGDIISFYNKVFVSRVRTFLL 866  Ostreococcus tauri
PRW05749   691 FKSIIAAYKQQPQARSDTFKRVSMtprertslhsmggpphADIIAFYNQVFLPHTKPFLL 750  Chlorella sorokiniana
PNR34109   100 FRDIIYHYRKQPQCKPYVFRNVLLdgsvvwrs-gkagqetGDIIRFYNEVFVPSTKSFLL 158  Physcomitrella patens

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