4YOZ


Conserved Protein Domain Family
CYCLIN_RBL

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cd20600: CYCLIN_RBL 
Click on image for an interactive view with Cn3D
cyclin box found in retinoblastoma-like protein (RBL) subfamily
The RBL subfamily includes two retinoblastoma-like proteins, RBL1 and RBL2. They are key regulators of entry into cell division and are directly involved in heterochromatin formation by maintaining overall chromatin structure. RBL1 and RBL2 recruit and target histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. They control histone H4 'Lys-20' trimethylation and probably act as transcription repressors by recruiting chromatin-modifying enzymes to promoters. They may also act as tumor suppressors. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410303
Aligned: 12 rows
Threshold Bit Score: 191.077
Created: 30-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
LxCxE peptide
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:LxCxE peptide binding site [polypeptide binding site]
Evidence:
  • Comment:The HPV E7 peptide contains the LxCxE motif, shared by other Rb-binding viral and cellular proteins.
  • Structure:4YOZ; Homo sapiens RBL1 in complex with HPV E7 peptide, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                         #   ##      ### 
4YOZ_A        222 SLALFYRKVYHLASVRLRDLCLKLdv-sNELRRKIWTCFEFTLVHcp-dLMKDRHLDQLLLCAFYIMAKVTKEe-rTFQE 298  human
Q08999        835 SLSLFFRKVYHLAAVRLRDLCAKLdi-sDELRKKIWTCFEFSIIQcp-eLMMDRHLDQLLMCAIYVMAKVTKEd-kSFQN 911  human
XP_002124769  744 SLALFFRKVYHLASVRLRHLCEQLvi-pPDLRAKIWTCFEYSVSKhaysLMRDRHIDQMLMCAVYVIAKITQHd-hSFQE 821  vase tunicate
XP_002612380  762 SLGLFFRKVYHLASVRLRDLCEKLev-gDELRRKMWTCFTHTLKEhv-eLMRDRHLDQIVMCSIYVMAKVTQHd-kSFQD 838  Florida lancelet
ELU08799      706 SLPLFFRKVYHLASVRLRDLCERLdv-dCELRAKIWTCFEHVLMEhi-eLMRDRHLDQMIMSSVYVMSKVTEKd-tSFQE 782  Capitella teleta
XP_002737957  556 SLGLFFRKVYHLANVRLLELCNRLei-vDDLRRKIWTCFEHSLVHsv-dLMMDRHLDQLLMCAVYVICKVTAQd-rTFQE 632  Saccoglossus ...
KFM66623      771 SLGLFFRKVYHLAGVRLKELCDKLsildDELRRKIWTCFEYSLMQht-dLMCDRHLDQLLMCAVYVICKVTKEd-rSFQE 848  Stegodyphus m...
KOF82677      888 SLALFFRKVYHLAGVRLRDLCEKLkvneEELQRKMWTCLEHCLVNei-sLMKDRHLDQIIMCSMYVIAKVATDppqTFQN 966  Octopus bimac...
XP_013394897  721 SLALFFRKVYHMASIRLKDLCDRLev-nEDLRRKMWTCFEQSLVHqi-eLMRDRHLDQLIMCAVYVMAKVSGQd-qSFQE 797  Lingula anatina
PIK39190      262 SLGMFFRKVYHVLNIRLRDMCAKLsi-sEELRRKIWTCLEHCLVNhi-nMMKDRNIDQLLLCSIYIICRVTDQp-nSFQN 338  Japanese sea ...
RDD47428      657 SLGLFFRKFYYLASVRLKDLCRSLhl-gEDLTSKIWTCFEYSVMHch-eLIIDRHLDQLLMCAIYVICKVSRKn-iKFLE 733  Trichoplax sp...
EFX76662      739 SLSLFFRKFYHLASVRLQDLCNRLelyeEDLRKKIWTCFEFSVMKhs-dLMQDRHLDQILMCAVYVICKVTGRd-kNFTD 816  common water ...
Feature 1                                                                                         
4YOZ_A        299 IMKSYRNQPQANShvyrsvll----------------------------------------------------------- 319  human
Q08999        912 IMRCYRTQPQARSqvyrsvlikgkrkrrnsgssdsrshqnsptelnkdrtsr-----------------dsspvmrssst 974  human
XP_002124769  822 IMRCYRSQPQATSnvyrnvlihrsssprlipaqppsrsm----------------------------------------- 860  vase tunicate
XP_002612380  839 IMKCYRTQPQASShvsltflnrylnhkhsidnqhfsrmylq--------------------------------------- 879  Florida lancelet
ELU08799      783 IMRCYRLQPQAQShvyrsvlltsrkrhssgdstvtsrsaspveaarterlst------------------irststlpaa 844  Capitella teleta
XP_002737957  633 IMKCYRLQPQAAShvyrsvlltsrrrhssnssdgsmrngtsrhgspvqqtgsng--------------sgspvqirstst 698  Saccoglossus ...
KFM66623      849 IMKYYRLQPQAAShvyrsvllvskgnkkrrnsgnsdnskdgsgsnspvpsensksdantdkeekeskrteqlstirssst 928  Stegodyphus m...
KOF82677      967 IMRCYRLQPQAQShvyrnvllstrrrrtsgssdssrngtsgssspvtteredskekd--------krrtealsirssstl 1038 Octopus bimac...
XP_013394897  798 IMKLYRLQPQAQShvyrsvllksrarhssggsnssngasgssspvnieeqnrekek----------krterlssirssst 867  Lingula anatina
PIK39190      339 IMKCYRRQPQADShvyrsvllsknespqkggattrkektlpqtpekq---------------------------kgrsrs 391  Japanese sea ...
RDD47428      734 IKDCYNRQPQAKKhlyrnvlvrkrkgksdnksvessrnsspvsppiiisgst-----------------ttyqeqnetam 796  Trichoplax sp...
EFX76662      817 IMRCYRTQPHASShvyrsvllctkarrgsaseeddeaatgstvkvngdekkaetn------------gekalppvrssst 884  common water ...
Feature 1                                      # #  ##           #  
4YOZ_A        320 ---------------------ksikeerGDLIKFYNTIYvgRVKSFALKY 348  human
Q08999        975 lpvpqpssapptptrltgansdmeeeerGDLIQFYNNIYikQIKTFAMKY 1024 human
XP_002124769  861 --rsnstiprsdpssplpgstgggdgerDDLIQFYNKVYvpVMREYVKKF 908  vase tunicate
XP_002612380  880 -qelcissapptptrlaglgatvdgderGDLIQFYNTIFvtKLKSYVRKF 928  Florida lancelet
ELU08799      845 tpasqpptptrlagtgtafefedrgedrGDLIKFYNSVYvkKIKAFALRF 894  Capitella teleta
XP_002737957  699 lpvpqpnsapptptrlagtgscfddedrGDLIKFYNSIFvrKIQLFAMRF 748  Saccoglossus kowalevskii
KFM66623      929 lpvplpssqpptptklagtgnhfefeerGDLINFYNKVYvpKIQRFAYKF 978  Stegodyphus mimosarum
KOF82677     1039 pvphpnsqpptptkligmgstlemgeerGDLIQFYNQVFvkRIKEFALKF 1088 Octopus bimaculoides
XP_013394897  868 lpvphpssqpptptrltgtgsvfefeerGDLIKFYNSIYvkKMKTFALKF 917  Lingula anatina
PIK39190      392 anlkaassgpptptrmsgtsssfeneerGDLVAFYNSVYvkDMNDYAKKF 441  Japanese sea cucumber
RDD47428      797 rssstlsqtptpscsdvdvengeledvrGDLVQFYNEVYldAMKEFVLRF 846  Trichoplax sp. H2
EFX76662      885 lpfpqpsscpptptglagtsssfeyedrGDLILFYNTVYvrRLQAFALKF 934  common water flea

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