2IVX


Conserved Protein Domain Family
CYCLIN_CCNT2_rpt1
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cd20596: CYCLIN_CCNT2_rpt1 
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first cyclin box found in cyclin-T2 (CCNT2)
CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410299
Aligned: 6 rows
Threshold Bit Score: 298.885
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative CDK
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:putative CDK interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens CCNT1 (3MI9) binds CDK9.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ##                                                           ##               
2IVX_A         2 SSRWFFTREQLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFtKFNKNIISSTAL 81  human
O60583         8 SSRWFFTREQLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFtKFNKNIISSTAL 87  human
GCF52584      83 SSRWFFSREQLENTPTRRCGVEADKELSYRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMHHSFtKFNRNIISPTAL 162 Paroedura picta
NP_001087615   8 ASRWYFTREQLESSPSRKCGMEADKELSYRQQAANLVQDMGQRLNVSQLTINTAIVYMHRFYMHHSFtKFHRNVMSPTAL 87  African clawed ...
NP_956122      8 SSKWFFTREQLETTPSRRCGVEPDRELSYRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMYHSFtKFHRNIISPTTL 87  zebrafish
XP_006011564   8 TSRWFYTREQLENTPSRRCGVEADKELSYRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMQHSFtKFHRNTVSPTAL 87  coelacanth

Feature 1        ##  #  #  ####                           #   #  #   ### ## 
2IVX_A        82 FLAAKVEEQaRKLEHVIKVAHACLHPLEPlLDTKCDAYLQQTRELVILETIMLQTLGFE 140 human
O60583        88 FLAAKVEEQaRKLEHVIKVAHACLHPLEPlLDTKCDAYLQQTQELVILETIMLQTLGFE 146 human
GCF52584     163 FLAAKVEEQpRKLEHVIKVAHACLHPLEPqLDTKSDAYLQQAQELVILETIMLQTLGFE 221 Paroedura picta
NP_001087615  88 FLAAKVEEQpRKLEHVIKVAHACLNPVEPqLDTKSEAYLQQAQELVTLETIMLQTLGFE 146 African clawed frog
NP_956122     88 FLAAKVEEQpRKLEHVIKVAHACLNPQEPpLDTKSNAYLQQAQELVILETIVLQTLGFE 146 zebrafish
XP_006011564  88 FLAAKVEEQpRKLEHVIKVTHACLNPQEPqLDTKSDAYLQQAQELVILETIMLQTLGFE 146 coelacanth

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