Conserved Protein Domain Family
CYCLIN_CCNE2_rpt1

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cd20580: CYCLIN_CCNE2_rpt1 
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2)
CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410283
Aligned: 6 rows
Threshold Bit Score: 275.187
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative CDK
Feature 1:putative CDK interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens CCNE1 (1W98) binds CDK2.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              ## #  ##  ##  #   #                                  #                    
O96020       100 SPLPDLSWGCSKEVWLNMLKKESRYVHDKHFevLHSDLEPQMRSILLDWLLEVCEVYtLHRETFYLAQDFFDRFMLTQkd 179 human
NP_001026116 106 SPLPELTWGNSKDVWLNILKKENRYAHCKHFtsLHSSLQPHMRSILLDWLLEVCEVYaLHRETFYLAQDFFDRFMLTQkn 185 chicken
XP_014354300  98 SPLPFLSWGNSEDVWSNMLKKEIKYVHEKHFflLHPALKPHMRSILLDWLLEVCEVHtLHRETFYLAQDFFDRFMFTQtn 177 coelacanth
OCT74923     132 SPLPELSWGNSKDVWMKMISKESRYVHSSRLlqNHPMLNPDMRSVLLDWLLEVSEVYtLHRETFYLAQDFFDRFMLTQtr 211 African clawed ...
XP_007886564 112 SPLPALSWGNSEAVWTNMLKKETKYTHNKNVlsLHPSLQPKMRAILLDWLIEVCEVYtLHRETFYLAQDFFDRFMFTQen 191 elephant shark
NP_001002075  90 SPLPCLSWASSDDVWIKMLNKELKYVHDKSFiqQHSALQPKMRAILLDWLMEVSEVYtLHRETFYLAQDIFDRFMLTQkd 169 zebrafish
Feature 1                      #   #####   ##                #  ##  ##  ##
O96020       180 INKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACsEEDILRMELIILKALKW 236 human
NP_001026116 186 INKSMLQLIGITSLFIASKLEEIYAPKIQEFAYVTDGACsEDDIVRMELIMLKALKW 242 chicken
XP_014354300 178 INKNQVQLIGITSLFIAAKLEEIYPPKLHEFAYITDGACtEEDILDMELIILKVCCR 234 coelacanth
OCT74923     212 VDKSMLQLIGVTALFIASKLEEIYPPKLHEFAYITDGACsEDDILQMELIILKALKW 268 African clawed frog
XP_007886564 192 IHKSKLQLIGITSLFIAAKLEEIYPPKLHEFAYVTDGACtEDEILDMELLILKALNW 248 elephant shark
NP_001002075 170 IGKDQLQLIGITSLFIASKIEEIYPPKLQEFAYVTDGACnEEEILAKELVMLKALNW 226 zebrafish

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