3G33


Conserved Protein Domain Family
CYCLIN_CCND3_rpt2
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cd20578: CYCLIN_CCND3_rpt2 
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second cyclin box found in G1/S-specific cyclin-D3 (CCND3)
CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.
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Statistics
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PSSM-Id: 410281
Aligned: 3 rows
Threshold Bit Score: 216.079
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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homodimer
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:3G33: Human CCND3 forms a homodimer; contacts at 4A
  • Comment:The structure of CDK4/cyclin D3 shows a tetramer assembly: a homodimer of heterodimers (CDK4-CCND3).
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     ##  ##  ## ##  ##  #                      ###                   
3G33_B    170 IAHDFLAFILHRLSLPRDRqALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGacs--msGDELTELLAGIT 247 human
P30281    156 IAHDFLAFILHRLSLPRDRqALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGacs--msGDELTELLAGIT 233 human
Q5ZKI9    156 IANDFLAHILHHLPLPKDKmELVKKHAQTFIALCATDYTFAMYPPSMIATGSISAAVHGLSisvngfgGEAVTELLAGIT 235 chicken

Feature 1                      ####      
3G33_B    248 GTEVDCLRACQEQIEAALRESLREAAQ 274 human
P30281    234 GTEVDCLRACQEQIEAALRESLREASQ 260 human
Q5ZKI9    236 GTEVDCLKACQEQIEAALAESLKQASQ 262 chicken

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