Conserved Protein Domain Family
CYCLIN_CCND2_rpt2

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cd20577: CYCLIN_CCND2_rpt2 
second cyclin box found in G1/S-specific cyclin-D2 (CCND2)
CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410280
Aligned: 7 rows
Threshold Bit Score: 188.51
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P30279       155 TPHDFIEHILRKLPqqREKLSLIRKHAQTFIALCATDFKFaMYPPSMIATGSVGAAICGLQQDeevsSLTCDALTELLAK 234 human
P49706       155 TPHDFIEHILRKLPlpKDKLVLIRKHAQTFIALCATDFNFaMYPPSMIATGSVGAAICGLQLDdgdrSLSGDSLTDFLAK 234 chicken
P53782       155 TPHDFIEHILRKLPlpKDKLLLIRKHAQTFIALCATDFNFaMYPPSMIATGSVGAAICGLQLDvgetSLSGDSLTEHLAK 234 African clawed ...
XP_007902364 155 TPHDFIEHILKKLPlpKDKVPLIRKHAQTFIALCATDFKFaMYPPSMIATGSVGAAICGLQLDivdsSLSSDNLTDLLAK 234 elephant shark
Q1L8M6       154 TPLDFIEHILHKLPfhEDRLTLIRKHTQTFIALCATDHSFtMYPPSMIATGCVGAAVCGLQSSqsnqSLWGDNLMELLAK 233 zebrafish
XP_005989330 155 TPHDFIEHILRKLPlpKDKMPLVRKHAQTFIALCATDFNFaMYPPSMIATGSVGAAICGLQLDngesSLSGDSLTELLAK 234 coelacanth
XP_006002322 157 TPYDFIDHILHKLTftRAKLDLIRKHALTFIALCATDIKFtIHPPSMIAAGSIGAAVHGLGFFr--dPASSEVLMKLLAQ 234
P30279       235 ITnTDVDCLKACQEQIEAVLLNSLQ 259 human
P49706       235 ITsTDVDCLKACQEQIESVLVSNLR 259 chicken
P53782       235 ITsTDVDCLKACQEQIESVLVSSLR 259 African clawed frog
XP_007902364 235 IThTDVDCLKACQEQIESVLVSNLR 259 elephant shark
Q1L8M6       234 ITnTELDCLKSCQEQIEQLLTDSLK 258 zebrafish
XP_005989330 235 ITnTDVDCLKACQEQIESVLVSNLR 259 coelacanth
XP_006002322 235 TTnTELDCLKTCQEQIETALVENLK 259
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