3G33


Conserved Protein Domain Family
CYCLIN_CCND3_rpt1

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cd20575: CYCLIN_CCND3_rpt1 
Click on image for an interactive view with Cn3D
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins
CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410278
Aligned: 4 rows
Threshold Bit Score: 318.857
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                     #  #  ##                    #  #  ##  #  ####      
3G33_B        16 ELLCCEGTRHAPRAgpDPRLLGDQRVLQSLLRLEERYVPRaSYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLA 95  human
P30281         2 ELLCCEGTRHAPRAgpDPRLLGDQRVLQSLLRLEERYVPRaSYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLA 81  human
NP_001008453   2 ELLCVETAARVPRAgrDPQLLGDRRVLQNLLSQEERYSPRvSYFQCVQREIKPYMRKMLAFWMLEVCEEQKCEEEVFPLA 81  chicken
XP_006002322   3 QLFCAEGWSRVPRAqaDRRLLQDKRVLENLLRLEERYTSRvSYLQCVQRDVRPYMRKMLATWMLEVCEEQKCEEEVFLLA 82  coelacanth
Feature 1                                      ## #  #  #                #  ##  #   ###
3G33_B        96 MNYLDRYLSCVPTrKAQLQLLGAVCMLLASKLRETtPLTIEKLCIYTDHAVsPRQLRDWEVLVLGKLKWD 165 human
P30281        82 MNYLDRYLSCVPTrKAQLQLLGAVCMLLASKLRETtPLTIEKLCIYTDHAVsPRQLRDWEVLVLGKLKWD 151 human
NP_001008453  82 MNYVDRYLSSVPVrKNHLQLLGAVCMLLASKLRETmPLTVEKLCIYTDNSItPQQLLDWEILVLEKLKWD 151 chicken
XP_006002322  83 MNYVDRYLSTVPTsKSKLQLLGAVCMFLASKFRETiPFTAEKLCIYTDNSIaPEQLLDWEIVVLGKLKWD 152 coelacanth

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