Conserved Protein Domain Family
CYCLIN_CCND2_rpt1

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cd20574: CYCLIN_CCND2_rpt1 
first cyclin box found in G1/S-specific cyclin-D2 (CCND2)
CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410277
Aligned: 6 rows
Threshold Bit Score: 319.245
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative CDKD-type cyclin
Feature 1:putative CDK interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidences that Homo sapiens CCND1 (2W96) and CCND3 (3G33) binds CDK4.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #                                               
P30279         1 MELLCHEVDPVRRAvrDRNLLRDdRVLQNLLTIEERYLPqCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLA 80  human
P49706         1 MELLCCEVDPMRRAlpDPNLLYDdRVLHNLLTIEERYLPqCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLA 80  chicken
P53782         1 MELLCCEGDTVRRAqpDPALLLDdRVLHNLLTVEERYLPqCSYFKCVQKDIQPFMRRMVATWMLEVCEEQRCEEEVFPMA 80  African clawed ...
XP_005989329   1 MELLCCEYGDIRRAlpDPNLLCDdRVLQNLLTIEERYLPqCSYFKCVQKDIQPFMRGMVATWMLEVCEEQKCEEEVFPLA 80  coelacanth
NP_001082914   1 MELLCLEMDTIIRArpDPNLLYDdRVLQSLLTIEERFLPqCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLA 80  zebrafish
XP_007902364   1 MELLCCEVDAIRRAlpDRNLLYDdRVLQNLLTIEERYLPpCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLA 80  elephant shark
Feature 1                                      ## #  # ##                #  ##      ###
P30279        81 MNYLDRFLAGVPTpKSHLQLLGAVCMFLASKLKETsPLTAEKLCIYTDNSIkPQELLEWELVVLGKLKWN 150 human
P49706        81 MNYLDRFLAVVPTrKCHLQLLGAVCMFLASKLKETiPLTAEKLCIYTDNSIkPQELLEWELVVLGKLKWN 150 chicken
P53782        81 MNYLDRFLAVIPTrKCHLQLLGAVCMFLASKLKETiPLTAEKLCIYTDNSIkPQELLEWELVVLGKLKWN 150 African clawed frog
XP_005989329  81 MNYLDRFLAVVPTkKCHLQLLGAVCMFLASKLKETiPLTADKLCIYTNNSIkPQELLEWELVVLGKLKWN 150 coelacanth
NP_001082914  81 MNYLDRFLAVVPTrKCNLQLLGAVCMFLASKLKETrPLTAEKLCIYTDNSIrPQELLEWELVVLGKLKWN 150 zebrafish
XP_007902364  81 MNYLDRFLSVVPTrKCHLQLLGAVCMFLASKLKETiPLTAEKLCIYTDNSIrAHELLDWELVVLGKLKWN 150 elephant shark

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