Conserved Protein Domain Family
CYCLIN_CLBs_yeast_rpt1

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cd20568: CYCLIN_CLBs_yeast_rpt1 
first cyclin box found in yeast B-type cyclins
This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Statistics
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PSSM-Id: 410271
Aligned: 13 rows
Threshold Bit Score: 233.727
Created: 9-Jul-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative CDKB-type cyclin
Feature 1:putative CDK interface [polypeptide binding site]
Evidence:
  • Comment:CDK = cyclin-dependent kinase
  • Comment:Based on the structure evidences that Homo sapiens CCNB1 binds CDK1 and phospho-CDK2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ##  ##  ##  #                                                             
P24868    202 DPLMVSEEVNDIFDYLHHLEIITLPNKANLyk----hKNIKQNRDILVNWIIKIHNKFgLLPETLYLAINIMDRFLCEEV 277 Saccharomyces cere...
P36630    129 NPLMAEEYAPEIFEYIRKLDLKCLPNPKYMdq---qkELTWKMREILNEWLVEIHSNFcLMPETLYLAVNIIDRFLSRRS 205 Schizosaccharomyce...
P24865    156 DPSMVPDYDPEIFHYMQSLERKLAPPPNYMsv---qqEIDWVTRHMLVDWIVQVQIHFrLLPETLFLAVNLIDRFLSIKV 232 Schizosaccharomyce...
P30284    201 DPLMAAEYVVEIFDYLRELEMETLPNPDYIdh---qpDLEWKMRGILVDWLIEVHTRFrLLPETLFLAVNIIDRFLSAEV 277 Aspergillus nidula...
P24869    222 DPFMVSEYVNDIFEYLHQLEVITLPKKEDLyq----hRNIHQNRDILVNWLVKIHNKFgLLPETLYLAINIMDRFLGKEL 297 Saccharomyces cere...
AAC72972  166 DPLMVSEYVEEIMGYMRELEVLTLPLPDYMdr---qkELQWKMRGILVDWLIEVHAKFrLLPETLFLSVNIIDRFLSLRV 242 Pneumocystis carinii
P30283    155 DTAMVAEYSAEIFAFLYRRELETLPSHNYLldktskyYLRPSMRTILVDWLVEVHEKFqCYPETLFLSINLMDRFLAKNK 234 Saccharomyces cere...
P32943    113 DPFMVAEYTDSIFSHLYEKEIQMLPTHNYLmdtqspyHLKSSMRALLIDWLVEVHEKFhCLPETLFLAINLLDRFLSQNV 192 Saccharomyces cere...
P24870    161 DVVMVAELSNEIFEYMRKLEDLYKPNPYYMdk---qpELRWSFRSTLIDWIVQVHEKFqLLPETLYLCINIIDRYLCKEV 237 Saccharomyces cere...
P24871    200 DVVMVVEYASDIFYYLRELEVKYRPNPYYMqn---qvELTWPFRRTMIDWLVQLHFRFqLLPETLYLTINIVDRFLSKKT 276 Saccharomyces cere...
TFK20644  284 DPLLVSEYVIEIFNYMKQMELTTMPNPNYMes---qkELAWKMRGILTDWLVQVHVRFrLLPETLFLAVNIIDRFLSARV 360 Coprinopsis marces...
OAG30173   44 DVRMVAEYVPSILAAYQEEEDVFKPVPNYMnf---qgDLRWAMRTVLVDWIIDVHYKLhLLPETLYLAVNLIDRFLSVRV 120 Nematocida displodere
P10815    196 DPLMVSEYVVDIFEYLNELEIETMPSPTYMdr---qkELAWKMRGILTDWLIEVHSRFrLLPETLFLAVNIIDRFLSLRV 272 Schizosaccharomyce...
Feature 1                   ##  #####  ###                #  ##  ##  ##
P24868    278 VqLNRLQLVGTSCLFIASKYEEIYsPSIKHFAYETDGaCSVEDIKEGERFILEKLDF 334 Saccharomyces cerevisiae S288c
P36630    206 CsLSKFQLTGITALLIASKYEEVMcPSIQNFVYMTDGaFTVEDVCVAERYMLNVLNF 262 Schizosaccharomyces pombe 972h-
P24865    233 VsLQKVQLVGLSALLIACKYEEIHpPSIYNFAHVVQGiFTVDEIIRAERYMLMLLDF 289 Schizosaccharomyces pombe 972h-
P30284    278 VaLDRLQLVGVAAMFIASKYEEVLsPHVANFSHVADEtFSDKEILDAERHILATLEY 334 Aspergillus nidulans FGSC A4
P24869    298 VqLDKLQLVGTSCLFIASKYEEVYsPSIKHFASETDGaCTEDEIKEGEKFILKTLKF 354 Saccharomyces cerevisiae S288c
AAC72972  243 CsLPKLQLVGITALFIAAKYEEVMcPSIQNFMYMADGgYTNEEILKAEQYVLQVLGY 299 Pneumocystis carinii
P30283    235 VtMNKLQLLAVTSLFIAAKFEEVNlPKLAEYAYITDGaASKNDIKNAEMFMLTSLEF 291 Saccharomyces cerevisiae S288c
P32943    193 VkLNKLQLLCITCLFIACKFEEVKlPKITNFAYVTDGaATVEGIRKAELFVLSSLGY 249 Saccharomyces cerevisiae S288c
P24870    238 VpVNKFQLVGAASLFIAAKYEEINcPTIKDFVYMSENcYSRNDLLDAERTILNGLEF 294 Saccharomyces cerevisiae S288C
P24871    277 VtLNRFQLVGVSALFIAAKFEEINcPTLDDLVYMLENtYTRDDIIRAEQYMIDTLEF 333 Saccharomyces cerevisiae S288c
TFK20644  361 VsLAKLQLVGITCLFIASKVEEIIsPGVGHFLSVADStYTAAEILQAERYVLKTLDW 417 Coprinopsis marcescibilis
OAG30173  121 VsIGKLQLVGVSGLLVASKYEEVAsPSVETFVVLTDRsFTENDILRAEKYLLHCLEY 177 Nematocida displodere
P10815    273 CsLNKLQLVGIAALFIASKYEEVMcPSVQNFVYMADGgYDEEEILQAERYILRVLEF 329 Schizosaccharomyces pombe 972h-

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