Conserved Protein Domain Family
CYCLIN_CCNB2_rpt1
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cd20566: CYCLIN_CCNB2_rpt1 
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins
CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410269
Aligned: 6 rows
Threshold Bit Score: 271.736
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative CDKB-type cyclin
Feature 1:putative CDK interface [polypeptide binding site]
Evidence:
  • Comment:CDK = cyclin-dependent kinase
  • Comment:Based on the structure evidences that Homo sapiens CCNB1 binds CDK1 and phospho-CDK2
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ##  ##  ##  #                                                             
O95067       127 NPQLCSDYVKDIYQYLRQLEVLQSINPHFLDGrDINGRMRAILVDWLVQVHSKFrLLQETLYMCVGIMDRFLQVQPVSRK 206 human
XP_007904570 115 NPQMCSEYIMDIYKYLRQLEVQQSIKVKYLAGqEINERMRAILVDWLIQVHSRFhLLQETLYMGIAIVDRFLQSQPVSRK 194 elephant shark
P13351       124 NPQLCSDYVMDIYNYLKQLEVQQSVHPCYLEGkEINERMRAILVDWLVQVHSRFqLLQETLYMGVAIMDRFLQVQPVSRS 203 African clawed ...
XP_005998783 133 NPQLCSEYVKEIYQYLRQLEVQQSICPKYLEGqEINERMRAILVDWLIQVHSRFqLLQETLYMTIALMDRFLQVQPVSRK 212 coelacanth
Q60FX9       123 MPQLCSEYVKDIYVYLRNLEVQQCIRPRYMQGyEINERMRALLVDWLIQVHSRFqLLQETLYMTVAILDRFLQVQPVSRR 202 Japanese eel
P29332       131 NPQLCSDYVKDIYLYLRQLELQQSVRPHYLDGkTINGRMRAILVDWLVQVHSRFqLLQETLYMCVAVMDRFLQSHPVPRK 210 chicken

Feature 1                  ##  #####  ###                #  ##  ##  ##
O95067       207 KLQLVGITALLLASKYEEMFsPNIEDFVYITDNAYTSSQIREMETLILKELKF 259 human
XP_007904570 195 NLQLVGVTAMLLASKYEEMYaPEIGDFVYITDNAYTKAQIRQMEILILKELDF 247 elephant shark
P13351       204 KLQLVGVTSLLIASKYEEMYtPEVADFVYITDNAYTASQIREMEMIILRLLNF 256 African clawed frog
XP_005998783 213 KLQLVGVTSMLLASKYEEMYvPEIGDFVYITDNAYTKGQIREMEMIILKRLNF 265 coelacanth
Q60FX9       203 KLQLVGVTAMLVASKYEEMYaPEVGDFVYITDNAFTKAQIREMEMLILRDLNF 255 Japanese eel
P29332       211 RLQLVGVTALLLASKYEEMYsPDIADFVYITDNAYNSAEVREMEITILKELNF 263 chicken

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